A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/180309 |
Resumo: | Background: Naturalistic studies can be useful tools to understand how an intervention works in the real clinical practice. This study aims to investigate the outcomes in a naturalistically treated depressed inpatients cohort, who were referred, or not, to unilateral ECT. Methods: Depressed adults according to MINI admitted in a psychiatric unit were divided in unilateral ECT treated and non-ECT treated. Main outcomes were: depression improvement in Hamilton Rating Scale for Depression (HDRS-17) scores; response (HDRS-17 improvement ≥50 %); remission (HDRS-17 score ≤7); length of hospitalization. Results: Forty-three patients were included in unilateral ECT group and 104 in non-ECT group. No differences of psychotic symptoms, melancholic features or past maniac episode were found between groups. Unilateral ECT group had a mean HDRS-17 score higher than non-ECT group at admission (ECT: 25.05 ± 1.03; non-ECT: 21.61 ± 0.69; p = 0.001), but no significant difference was found at discharge (ECT: 7.70 ± 0.81; non-ECT: 7.40 ± 0.51; p = 0.75). Unilateral ECT group had a larger HDRS-17 score reduction during treatment (ECT: 18.24 ± 1.18; non-ECT:14.20 ± 0.76; p = 0.004). There were no significant differences in response and remission rates between groups. Unilateral ECT group had longer mean duration of hospitalization in days (ECT: 35.48 ± 2.48; non-ECT: 24.57 ± 1.50; p < 0.001), but there were no difference in mean time of treatment (ECT group:27.66 ± 1.95; non-ECT: 24.57 ± 1.50; p = 0.25). Conclusions: Unilateral high-dose ECT is still a useful treatment option, in the real world clinical practice, to reduce the intensity of depressive symptoms in highly depressed inpatients. |
id |
UFRGS-2_4b6ccb6b87d60c6b46a8ed33e1fed537 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/180309 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Alves, Lucas Primo de CarvalhoFreire, Thiago Fernando VasconcelosFleck, Marcelo Pio de AlmeidaRocha, Neusa Sica da2018-07-10T02:33:20Z20161471-244Xhttp://hdl.handle.net/10183/180309001067369Background: Naturalistic studies can be useful tools to understand how an intervention works in the real clinical practice. This study aims to investigate the outcomes in a naturalistically treated depressed inpatients cohort, who were referred, or not, to unilateral ECT. Methods: Depressed adults according to MINI admitted in a psychiatric unit were divided in unilateral ECT treated and non-ECT treated. Main outcomes were: depression improvement in Hamilton Rating Scale for Depression (HDRS-17) scores; response (HDRS-17 improvement ≥50 %); remission (HDRS-17 score ≤7); length of hospitalization. Results: Forty-three patients were included in unilateral ECT group and 104 in non-ECT group. No differences of psychotic symptoms, melancholic features or past maniac episode were found between groups. Unilateral ECT group had a mean HDRS-17 score higher than non-ECT group at admission (ECT: 25.05 ± 1.03; non-ECT: 21.61 ± 0.69; p = 0.001), but no significant difference was found at discharge (ECT: 7.70 ± 0.81; non-ECT: 7.40 ± 0.51; p = 0.75). Unilateral ECT group had a larger HDRS-17 score reduction during treatment (ECT: 18.24 ± 1.18; non-ECT:14.20 ± 0.76; p = 0.004). There were no significant differences in response and remission rates between groups. Unilateral ECT group had longer mean duration of hospitalization in days (ECT: 35.48 ± 2.48; non-ECT: 24.57 ± 1.50; p < 0.001), but there were no difference in mean time of treatment (ECT group:27.66 ± 1.95; non-ECT: 24.57 ± 1.50; p = 0.25). Conclusions: Unilateral high-dose ECT is still a useful treatment option, in the real world clinical practice, to reduce the intensity of depressive symptoms in highly depressed inpatients.application/pdfengBMC psychiatry. London. Vol. 16 (2016), 396, 8 p.Transtorno depressivo maiorTerapia combinadaEletroconvulsoterapiaAntidepressivosResultado do tratamentoTempo de internaçãoElectroconvulsive therapyDepressive disorderNaturalistic studyPragmatic clinical trials as topicA naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice?Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001067369.pdf001067369.pdfTexto completo (inglês)application/pdf796588http://www.lume.ufrgs.br/bitstream/10183/180309/1/001067369.pdf3414c436fccf0b133a36f0b9417a9af7MD51TEXT001067369.pdf.txt001067369.pdf.txtExtracted Texttext/plain36327http://www.lume.ufrgs.br/bitstream/10183/180309/2/001067369.pdf.txta9ef0d42223b000aa2b0a240d54a5c52MD5210183/1803092018-07-11 02:31:43.718488oai:www.lume.ufrgs.br:10183/180309Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-07-11T05:31:43Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice? |
title |
A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice? |
spellingShingle |
A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice? Alves, Lucas Primo de Carvalho Transtorno depressivo maior Terapia combinada Eletroconvulsoterapia Antidepressivos Resultado do tratamento Tempo de internação Electroconvulsive therapy Depressive disorder Naturalistic study Pragmatic clinical trials as topic |
title_short |
A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice? |
title_full |
A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice? |
title_fullStr |
A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice? |
title_full_unstemmed |
A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice? |
title_sort |
A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice? |
author |
Alves, Lucas Primo de Carvalho |
author_facet |
Alves, Lucas Primo de Carvalho Freire, Thiago Fernando Vasconcelos Fleck, Marcelo Pio de Almeida Rocha, Neusa Sica da |
author_role |
author |
author2 |
Freire, Thiago Fernando Vasconcelos Fleck, Marcelo Pio de Almeida Rocha, Neusa Sica da |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Alves, Lucas Primo de Carvalho Freire, Thiago Fernando Vasconcelos Fleck, Marcelo Pio de Almeida Rocha, Neusa Sica da |
dc.subject.por.fl_str_mv |
Transtorno depressivo maior Terapia combinada Eletroconvulsoterapia Antidepressivos Resultado do tratamento Tempo de internação |
topic |
Transtorno depressivo maior Terapia combinada Eletroconvulsoterapia Antidepressivos Resultado do tratamento Tempo de internação Electroconvulsive therapy Depressive disorder Naturalistic study Pragmatic clinical trials as topic |
dc.subject.eng.fl_str_mv |
Electroconvulsive therapy Depressive disorder Naturalistic study Pragmatic clinical trials as topic |
description |
Background: Naturalistic studies can be useful tools to understand how an intervention works in the real clinical practice. This study aims to investigate the outcomes in a naturalistically treated depressed inpatients cohort, who were referred, or not, to unilateral ECT. Methods: Depressed adults according to MINI admitted in a psychiatric unit were divided in unilateral ECT treated and non-ECT treated. Main outcomes were: depression improvement in Hamilton Rating Scale for Depression (HDRS-17) scores; response (HDRS-17 improvement ≥50 %); remission (HDRS-17 score ≤7); length of hospitalization. Results: Forty-three patients were included in unilateral ECT group and 104 in non-ECT group. No differences of psychotic symptoms, melancholic features or past maniac episode were found between groups. Unilateral ECT group had a mean HDRS-17 score higher than non-ECT group at admission (ECT: 25.05 ± 1.03; non-ECT: 21.61 ± 0.69; p = 0.001), but no significant difference was found at discharge (ECT: 7.70 ± 0.81; non-ECT: 7.40 ± 0.51; p = 0.75). Unilateral ECT group had a larger HDRS-17 score reduction during treatment (ECT: 18.24 ± 1.18; non-ECT:14.20 ± 0.76; p = 0.004). There were no significant differences in response and remission rates between groups. Unilateral ECT group had longer mean duration of hospitalization in days (ECT: 35.48 ± 2.48; non-ECT: 24.57 ± 1.50; p < 0.001), but there were no difference in mean time of treatment (ECT group:27.66 ± 1.95; non-ECT: 24.57 ± 1.50; p = 0.25). Conclusions: Unilateral high-dose ECT is still a useful treatment option, in the real world clinical practice, to reduce the intensity of depressive symptoms in highly depressed inpatients. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2018-07-10T02:33:20Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/180309 |
dc.identifier.issn.pt_BR.fl_str_mv |
1471-244X |
dc.identifier.nrb.pt_BR.fl_str_mv |
001067369 |
identifier_str_mv |
1471-244X 001067369 |
url |
http://hdl.handle.net/10183/180309 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
BMC psychiatry. London. Vol. 16 (2016), 396, 8 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/180309/1/001067369.pdf http://www.lume.ufrgs.br/bitstream/10183/180309/2/001067369.pdf.txt |
bitstream.checksum.fl_str_mv |
3414c436fccf0b133a36f0b9417a9af7 a9ef0d42223b000aa2b0a240d54a5c52 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224946892931072 |