Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/110036 |
Resumo: | Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether Brain Derived Neurotrophic Factor (BDNF) levels are associated with cognitive impairment in FEP patients compared with healthy controls. Methods: 45 FEP patients and 45 healthy controls matched by age, gender and educational level were selected from the Basque Country area of Spain. Plasma BDNF levels were assessed in healthy controls and in patients. A battery of cognitive tests was applied to both groups, with the patients being assessed at 6 months after the acute episode and only in those with a clinical response to treatment. Results: Plasma BDNF levels were altered in patients compared with the control group. In FEP patients, we observed a positive association between BDNF levels at six months and five cognitive domains (learning ability, immediate and delayed memory, abstract thinking and processing speed) which persisted after controlling for medications prescribed, drug use, intelligence quotient (IQ) and negative symptoms. In the healthy control group, BDNF levels were not associated with cognitive test scores. Conclusion: Our results suggest that BDNF is associated with the cognitive impairment seen after a FEP. Further investigations of the role of this neurotrophin in the symptoms associated with psychosis onset are warranted. |
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Azúa García, Sonia Ruiz deMatute, CarlosStertz, LauraMosquera, FernandoPalomino, AitorDe la Rosa, IrisBarbeito, SaraVega, PatriciaKapczinski, Flávio PereiraGonzález-Pinto, Ana2015-02-12T02:15:17Z20131471-244Xhttp://hdl.handle.net/10183/110036000875649Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether Brain Derived Neurotrophic Factor (BDNF) levels are associated with cognitive impairment in FEP patients compared with healthy controls. Methods: 45 FEP patients and 45 healthy controls matched by age, gender and educational level were selected from the Basque Country area of Spain. Plasma BDNF levels were assessed in healthy controls and in patients. A battery of cognitive tests was applied to both groups, with the patients being assessed at 6 months after the acute episode and only in those with a clinical response to treatment. Results: Plasma BDNF levels were altered in patients compared with the control group. In FEP patients, we observed a positive association between BDNF levels at six months and five cognitive domains (learning ability, immediate and delayed memory, abstract thinking and processing speed) which persisted after controlling for medications prescribed, drug use, intelligence quotient (IQ) and negative symptoms. In the healthy control group, BDNF levels were not associated with cognitive test scores. Conclusion: Our results suggest that BDNF is associated with the cognitive impairment seen after a FEP. Further investigations of the role of this neurotrophin in the symptoms associated with psychosis onset are warranted.application/pdfengBMC Psychiatry. London. Vol. 13, n. 66 (2013), 27, [9] f.Fator neurotrófico derivado do encéfaloCogniçãoAprendizagemPsychotic disorderBrain-derived neurotrophic factorSchizophreniaCognitionPlasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosisEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000875649.pdf000875649.pdfTexto completo (inglês)application/pdf191130http://www.lume.ufrgs.br/bitstream/10183/110036/1/000875649.pdf38f428b7314600f8f2651c9aaeb227c8MD51TEXT000875649.pdf.txt000875649.pdf.txtExtracted Texttext/plain46096http://www.lume.ufrgs.br/bitstream/10183/110036/2/000875649.pdf.txt5ce9986a22ce9acbaace8560f3fd028dMD52THUMBNAIL000875649.pdf.jpg000875649.pdf.jpgGenerated Thumbnailimage/jpeg1936http://www.lume.ufrgs.br/bitstream/10183/110036/3/000875649.pdf.jpg1e684e6c536d5800e298f919503a766cMD5310183/1100362023-06-15 03:26:34.101707oai:www.lume.ufrgs.br:10183/110036Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-06-15T06:26:34Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis |
title |
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis |
spellingShingle |
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis Azúa García, Sonia Ruiz de Fator neurotrófico derivado do encéfalo Cognição Aprendizagem Psychotic disorder Brain-derived neurotrophic factor Schizophrenia Cognition |
title_short |
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis |
title_full |
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis |
title_fullStr |
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis |
title_full_unstemmed |
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis |
title_sort |
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis |
author |
Azúa García, Sonia Ruiz de |
author_facet |
Azúa García, Sonia Ruiz de Matute, Carlos Stertz, Laura Mosquera, Fernando Palomino, Aitor De la Rosa, Iris Barbeito, Sara Vega, Patricia Kapczinski, Flávio Pereira González-Pinto, Ana |
author_role |
author |
author2 |
Matute, Carlos Stertz, Laura Mosquera, Fernando Palomino, Aitor De la Rosa, Iris Barbeito, Sara Vega, Patricia Kapczinski, Flávio Pereira González-Pinto, Ana |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Azúa García, Sonia Ruiz de Matute, Carlos Stertz, Laura Mosquera, Fernando Palomino, Aitor De la Rosa, Iris Barbeito, Sara Vega, Patricia Kapczinski, Flávio Pereira González-Pinto, Ana |
dc.subject.por.fl_str_mv |
Fator neurotrófico derivado do encéfalo Cognição Aprendizagem |
topic |
Fator neurotrófico derivado do encéfalo Cognição Aprendizagem Psychotic disorder Brain-derived neurotrophic factor Schizophrenia Cognition |
dc.subject.eng.fl_str_mv |
Psychotic disorder Brain-derived neurotrophic factor Schizophrenia Cognition |
description |
Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether Brain Derived Neurotrophic Factor (BDNF) levels are associated with cognitive impairment in FEP patients compared with healthy controls. Methods: 45 FEP patients and 45 healthy controls matched by age, gender and educational level were selected from the Basque Country area of Spain. Plasma BDNF levels were assessed in healthy controls and in patients. A battery of cognitive tests was applied to both groups, with the patients being assessed at 6 months after the acute episode and only in those with a clinical response to treatment. Results: Plasma BDNF levels were altered in patients compared with the control group. In FEP patients, we observed a positive association between BDNF levels at six months and five cognitive domains (learning ability, immediate and delayed memory, abstract thinking and processing speed) which persisted after controlling for medications prescribed, drug use, intelligence quotient (IQ) and negative symptoms. In the healthy control group, BDNF levels were not associated with cognitive test scores. Conclusion: Our results suggest that BDNF is associated with the cognitive impairment seen after a FEP. Further investigations of the role of this neurotrophin in the symptoms associated with psychosis onset are warranted. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
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2015-02-12T02:15:17Z |
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000875649 |
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BMC Psychiatry. London. Vol. 13, n. 66 (2013), 27, [9] f. |
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