Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats

Detalhes bibliográficos
Autor(a) principal: Malfitano, Christiane
Data de Publicação: 2014
Outros Autores: Barboza, Catarina de Andrade, Mostarda, Cristiano Teixeira, Palma, Renata Kelly da, Santos, Camila Paixão dos, Rodrigues, Bruno (Medicina), Freitas, Sarah Cristina Ferreira, Belló-Klein, Adriane, Llesuy, Susana Francisca, Irigoyen, Maria Claudia Costa, De Angelis, Kátia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/111831
Resumo: Background: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Male Wistar rats were divided into: control (C), diabetic (D), myocardial infarcted (MI) and diabetic infarcted rats (DMI). Methods: Diabetes was induced by streptozotocin (STZ, 50 mg/Kg) at the beginning of the protocol and MI was induced by left coronary occlusion 15 days after STZ. Thirty days after streptozocin-induced diabetes, cardiovascular autonomic modulation was evaluated by spectral analysis, and oxidative stress profile was determined by antioxidant enzyme activities and superoxide anion, together with protein carbonylation and redox balance of glutathione (GSH/GSSG). Results: The diabetic and infarcted groups showed decreased heart rate variability and vagal modulation (p < 0.05); however, sympathetic modulation decreased only in diabetic groups (p < 0.05). Sympatho/vagal balance and vascular sympathetic modulation were increased only in the MI group (p < 0.05). Diabetes promoted an increase in catalase concentration (p < 0.05). Glutathione peroxidase activity was increased only in DMI when compared to the other groups (p < 0.05). Superoxide anion and protein carbonylation were increased only in MI group (p < 0.05). Cardiac redox balance, as evaluated by GSH/GSSG, was lower in the MI group (p < 0.05). Conclusions: These data suggest that hyperglycemia promotes compensatory mechanisms that may offer protection against ischemia, as demonstrated by increased antioxidants, decreased pro-oxidants and protein damage, possibly related to the improvements in both redox balance and sympathetic modulation to the heart.
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spelling Malfitano, ChristianeBarboza, Catarina de AndradeMostarda, Cristiano TeixeiraPalma, Renata Kelly daSantos, Camila Paixão dosRodrigues, Bruno (Medicina)Freitas, Sarah Cristina FerreiraBelló-Klein, AdrianeLlesuy, Susana FranciscaIrigoyen, Maria Claudia CostaDe Angelis, Kátia2015-03-07T01:57:11Z20141475-2840http://hdl.handle.net/10183/111831000953451Background: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Male Wistar rats were divided into: control (C), diabetic (D), myocardial infarcted (MI) and diabetic infarcted rats (DMI). Methods: Diabetes was induced by streptozotocin (STZ, 50 mg/Kg) at the beginning of the protocol and MI was induced by left coronary occlusion 15 days after STZ. Thirty days after streptozocin-induced diabetes, cardiovascular autonomic modulation was evaluated by spectral analysis, and oxidative stress profile was determined by antioxidant enzyme activities and superoxide anion, together with protein carbonylation and redox balance of glutathione (GSH/GSSG). Results: The diabetic and infarcted groups showed decreased heart rate variability and vagal modulation (p < 0.05); however, sympathetic modulation decreased only in diabetic groups (p < 0.05). Sympatho/vagal balance and vascular sympathetic modulation were increased only in the MI group (p < 0.05). Diabetes promoted an increase in catalase concentration (p < 0.05). Glutathione peroxidase activity was increased only in DMI when compared to the other groups (p < 0.05). Superoxide anion and protein carbonylation were increased only in MI group (p < 0.05). Cardiac redox balance, as evaluated by GSH/GSSG, was lower in the MI group (p < 0.05). Conclusions: These data suggest that hyperglycemia promotes compensatory mechanisms that may offer protection against ischemia, as demonstrated by increased antioxidants, decreased pro-oxidants and protein damage, possibly related to the improvements in both redox balance and sympathetic modulation to the heart.application/pdfengCardiovascular diabetology. London. Vol. 13 ( 10 Out. 2014), p. 131, [9] p.Estresse oxidativoDiabetes mellitusHiperglicemiaInfarto do miocárdioAutonomic modulationOxidative stressDiabetic hyperglycemiaMyocardial infarctionDiabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in ratsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000953451.pdf000953451.pdfTexto completo (inglês)application/pdf351118http://www.lume.ufrgs.br/bitstream/10183/111831/1/000953451.pdf5576385b6b50439f4039522d281aefdaMD51TEXT000953451.pdf.txt000953451.pdf.txtExtracted Texttext/plain46682http://www.lume.ufrgs.br/bitstream/10183/111831/2/000953451.pdf.txtfdf4418f042002ac70230173e9622e55MD52THUMBNAIL000953451.pdf.jpg000953451.pdf.jpgGenerated Thumbnailimage/jpeg1956http://www.lume.ufrgs.br/bitstream/10183/111831/3/000953451.pdf.jpg33abc9cb682bd19ee1c2bb882403608cMD5310183/1118312019-01-11 04:08:43.576067oai:www.lume.ufrgs.br:10183/111831Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-01-11T06:08:43Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
title Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
spellingShingle Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
Malfitano, Christiane
Estresse oxidativo
Diabetes mellitus
Hiperglicemia
Infarto do miocárdio
Autonomic modulation
Oxidative stress
Diabetic hyperglycemia
Myocardial infarction
title_short Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
title_full Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
title_fullStr Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
title_full_unstemmed Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
title_sort Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
author Malfitano, Christiane
author_facet Malfitano, Christiane
Barboza, Catarina de Andrade
Mostarda, Cristiano Teixeira
Palma, Renata Kelly da
Santos, Camila Paixão dos
Rodrigues, Bruno (Medicina)
Freitas, Sarah Cristina Ferreira
Belló-Klein, Adriane
Llesuy, Susana Francisca
Irigoyen, Maria Claudia Costa
De Angelis, Kátia
author_role author
author2 Barboza, Catarina de Andrade
Mostarda, Cristiano Teixeira
Palma, Renata Kelly da
Santos, Camila Paixão dos
Rodrigues, Bruno (Medicina)
Freitas, Sarah Cristina Ferreira
Belló-Klein, Adriane
Llesuy, Susana Francisca
Irigoyen, Maria Claudia Costa
De Angelis, Kátia
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Malfitano, Christiane
Barboza, Catarina de Andrade
Mostarda, Cristiano Teixeira
Palma, Renata Kelly da
Santos, Camila Paixão dos
Rodrigues, Bruno (Medicina)
Freitas, Sarah Cristina Ferreira
Belló-Klein, Adriane
Llesuy, Susana Francisca
Irigoyen, Maria Claudia Costa
De Angelis, Kátia
dc.subject.por.fl_str_mv Estresse oxidativo
Diabetes mellitus
Hiperglicemia
Infarto do miocárdio
topic Estresse oxidativo
Diabetes mellitus
Hiperglicemia
Infarto do miocárdio
Autonomic modulation
Oxidative stress
Diabetic hyperglycemia
Myocardial infarction
dc.subject.eng.fl_str_mv Autonomic modulation
Oxidative stress
Diabetic hyperglycemia
Myocardial infarction
description Background: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Male Wistar rats were divided into: control (C), diabetic (D), myocardial infarcted (MI) and diabetic infarcted rats (DMI). Methods: Diabetes was induced by streptozotocin (STZ, 50 mg/Kg) at the beginning of the protocol and MI was induced by left coronary occlusion 15 days after STZ. Thirty days after streptozocin-induced diabetes, cardiovascular autonomic modulation was evaluated by spectral analysis, and oxidative stress profile was determined by antioxidant enzyme activities and superoxide anion, together with protein carbonylation and redox balance of glutathione (GSH/GSSG). Results: The diabetic and infarcted groups showed decreased heart rate variability and vagal modulation (p < 0.05); however, sympathetic modulation decreased only in diabetic groups (p < 0.05). Sympatho/vagal balance and vascular sympathetic modulation were increased only in the MI group (p < 0.05). Diabetes promoted an increase in catalase concentration (p < 0.05). Glutathione peroxidase activity was increased only in DMI when compared to the other groups (p < 0.05). Superoxide anion and protein carbonylation were increased only in MI group (p < 0.05). Cardiac redox balance, as evaluated by GSH/GSSG, was lower in the MI group (p < 0.05). Conclusions: These data suggest that hyperglycemia promotes compensatory mechanisms that may offer protection against ischemia, as demonstrated by increased antioxidants, decreased pro-oxidants and protein damage, possibly related to the improvements in both redox balance and sympathetic modulation to the heart.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-03-07T01:57:11Z
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dc.relation.ispartof.pt_BR.fl_str_mv Cardiovascular diabetology. London. Vol. 13 ( 10 Out. 2014), p. 131, [9] p.
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