Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/111831 |
Resumo: | Background: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Male Wistar rats were divided into: control (C), diabetic (D), myocardial infarcted (MI) and diabetic infarcted rats (DMI). Methods: Diabetes was induced by streptozotocin (STZ, 50 mg/Kg) at the beginning of the protocol and MI was induced by left coronary occlusion 15 days after STZ. Thirty days after streptozocin-induced diabetes, cardiovascular autonomic modulation was evaluated by spectral analysis, and oxidative stress profile was determined by antioxidant enzyme activities and superoxide anion, together with protein carbonylation and redox balance of glutathione (GSH/GSSG). Results: The diabetic and infarcted groups showed decreased heart rate variability and vagal modulation (p < 0.05); however, sympathetic modulation decreased only in diabetic groups (p < 0.05). Sympatho/vagal balance and vascular sympathetic modulation were increased only in the MI group (p < 0.05). Diabetes promoted an increase in catalase concentration (p < 0.05). Glutathione peroxidase activity was increased only in DMI when compared to the other groups (p < 0.05). Superoxide anion and protein carbonylation were increased only in MI group (p < 0.05). Cardiac redox balance, as evaluated by GSH/GSSG, was lower in the MI group (p < 0.05). Conclusions: These data suggest that hyperglycemia promotes compensatory mechanisms that may offer protection against ischemia, as demonstrated by increased antioxidants, decreased pro-oxidants and protein damage, possibly related to the improvements in both redox balance and sympathetic modulation to the heart. |
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Malfitano, ChristianeBarboza, Catarina de AndradeMostarda, Cristiano TeixeiraPalma, Renata Kelly daSantos, Camila Paixão dosRodrigues, Bruno (Medicina)Freitas, Sarah Cristina FerreiraBelló-Klein, AdrianeLlesuy, Susana FranciscaIrigoyen, Maria Claudia CostaDe Angelis, Kátia2015-03-07T01:57:11Z20141475-2840http://hdl.handle.net/10183/111831000953451Background: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Male Wistar rats were divided into: control (C), diabetic (D), myocardial infarcted (MI) and diabetic infarcted rats (DMI). Methods: Diabetes was induced by streptozotocin (STZ, 50 mg/Kg) at the beginning of the protocol and MI was induced by left coronary occlusion 15 days after STZ. Thirty days after streptozocin-induced diabetes, cardiovascular autonomic modulation was evaluated by spectral analysis, and oxidative stress profile was determined by antioxidant enzyme activities and superoxide anion, together with protein carbonylation and redox balance of glutathione (GSH/GSSG). Results: The diabetic and infarcted groups showed decreased heart rate variability and vagal modulation (p < 0.05); however, sympathetic modulation decreased only in diabetic groups (p < 0.05). Sympatho/vagal balance and vascular sympathetic modulation were increased only in the MI group (p < 0.05). Diabetes promoted an increase in catalase concentration (p < 0.05). Glutathione peroxidase activity was increased only in DMI when compared to the other groups (p < 0.05). Superoxide anion and protein carbonylation were increased only in MI group (p < 0.05). Cardiac redox balance, as evaluated by GSH/GSSG, was lower in the MI group (p < 0.05). Conclusions: These data suggest that hyperglycemia promotes compensatory mechanisms that may offer protection against ischemia, as demonstrated by increased antioxidants, decreased pro-oxidants and protein damage, possibly related to the improvements in both redox balance and sympathetic modulation to the heart.application/pdfengCardiovascular diabetology. London. Vol. 13 ( 10 Out. 2014), p. 131, [9] p.Estresse oxidativoDiabetes mellitusHiperglicemiaInfarto do miocárdioAutonomic modulationOxidative stressDiabetic hyperglycemiaMyocardial infarctionDiabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in ratsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000953451.pdf000953451.pdfTexto completo (inglês)application/pdf351118http://www.lume.ufrgs.br/bitstream/10183/111831/1/000953451.pdf5576385b6b50439f4039522d281aefdaMD51TEXT000953451.pdf.txt000953451.pdf.txtExtracted Texttext/plain46682http://www.lume.ufrgs.br/bitstream/10183/111831/2/000953451.pdf.txtfdf4418f042002ac70230173e9622e55MD52THUMBNAIL000953451.pdf.jpg000953451.pdf.jpgGenerated Thumbnailimage/jpeg1956http://www.lume.ufrgs.br/bitstream/10183/111831/3/000953451.pdf.jpg33abc9cb682bd19ee1c2bb882403608cMD5310183/1118312019-01-11 04:08:43.576067oai:www.lume.ufrgs.br:10183/111831Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-01-11T06:08:43Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats |
title |
Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats |
spellingShingle |
Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats Malfitano, Christiane Estresse oxidativo Diabetes mellitus Hiperglicemia Infarto do miocárdio Autonomic modulation Oxidative stress Diabetic hyperglycemia Myocardial infarction |
title_short |
Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats |
title_full |
Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats |
title_fullStr |
Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats |
title_full_unstemmed |
Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats |
title_sort |
Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats |
author |
Malfitano, Christiane |
author_facet |
Malfitano, Christiane Barboza, Catarina de Andrade Mostarda, Cristiano Teixeira Palma, Renata Kelly da Santos, Camila Paixão dos Rodrigues, Bruno (Medicina) Freitas, Sarah Cristina Ferreira Belló-Klein, Adriane Llesuy, Susana Francisca Irigoyen, Maria Claudia Costa De Angelis, Kátia |
author_role |
author |
author2 |
Barboza, Catarina de Andrade Mostarda, Cristiano Teixeira Palma, Renata Kelly da Santos, Camila Paixão dos Rodrigues, Bruno (Medicina) Freitas, Sarah Cristina Ferreira Belló-Klein, Adriane Llesuy, Susana Francisca Irigoyen, Maria Claudia Costa De Angelis, Kátia |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Malfitano, Christiane Barboza, Catarina de Andrade Mostarda, Cristiano Teixeira Palma, Renata Kelly da Santos, Camila Paixão dos Rodrigues, Bruno (Medicina) Freitas, Sarah Cristina Ferreira Belló-Klein, Adriane Llesuy, Susana Francisca Irigoyen, Maria Claudia Costa De Angelis, Kátia |
dc.subject.por.fl_str_mv |
Estresse oxidativo Diabetes mellitus Hiperglicemia Infarto do miocárdio |
topic |
Estresse oxidativo Diabetes mellitus Hiperglicemia Infarto do miocárdio Autonomic modulation Oxidative stress Diabetic hyperglycemia Myocardial infarction |
dc.subject.eng.fl_str_mv |
Autonomic modulation Oxidative stress Diabetic hyperglycemia Myocardial infarction |
description |
Background: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Male Wistar rats were divided into: control (C), diabetic (D), myocardial infarcted (MI) and diabetic infarcted rats (DMI). Methods: Diabetes was induced by streptozotocin (STZ, 50 mg/Kg) at the beginning of the protocol and MI was induced by left coronary occlusion 15 days after STZ. Thirty days after streptozocin-induced diabetes, cardiovascular autonomic modulation was evaluated by spectral analysis, and oxidative stress profile was determined by antioxidant enzyme activities and superoxide anion, together with protein carbonylation and redox balance of glutathione (GSH/GSSG). Results: The diabetic and infarcted groups showed decreased heart rate variability and vagal modulation (p < 0.05); however, sympathetic modulation decreased only in diabetic groups (p < 0.05). Sympatho/vagal balance and vascular sympathetic modulation were increased only in the MI group (p < 0.05). Diabetes promoted an increase in catalase concentration (p < 0.05). Glutathione peroxidase activity was increased only in DMI when compared to the other groups (p < 0.05). Superoxide anion and protein carbonylation were increased only in MI group (p < 0.05). Cardiac redox balance, as evaluated by GSH/GSSG, was lower in the MI group (p < 0.05). Conclusions: These data suggest that hyperglycemia promotes compensatory mechanisms that may offer protection against ischemia, as demonstrated by increased antioxidants, decreased pro-oxidants and protein damage, possibly related to the improvements in both redox balance and sympathetic modulation to the heart. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-03-07T01:57:11Z |
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Estrangeiro info:eu-repo/semantics/article |
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publishedVersion |
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1475-2840 |
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000953451 |
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dc.language.iso.fl_str_mv |
eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Cardiovascular diabetology. London. Vol. 13 ( 10 Out. 2014), p. 131, [9] p. |
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