Are there regional variations in the presentation of childhood leukemia?
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/233491 |
Resumo: | Introduction: Treatment of childhood acute lymphoblastic leukemia (ALL) is based on risk stratification. This study aimed to assess the agreement between risk group classifications in the different childhood ALL treatment protocols used in a referral hospital in southern Brazil. Methods: We retrospectively reviewed the medical records of patients aged 1 to 18 years with B-cell ALL treated at a hospital from January 2013 to April 2017. Agreement between risk classifications was assessed by the kappa coefficient. Results: Seventy-five patients were analyzed. There was poor agreement between risk stratification by GBTLI 2009 and BFM 95 protocols (kappa=0.22; p = 0.003) and by GBTLI 2009 and IC-BFM 2002 protocols (kappa=0.24; p = 0.002). Risk group distribution was 13.3% for low risk, 32.0% for intermediate risk, and 54.7% for high risk based on stratification by the GBTLI 2009 protocol, and 28.0% for low risk, 42.7% for intermediate risk, and 29.3% for high risk based on stratification by the IC-BFM 2002 protocol. Overall survival was 68.6%. Conclusion: This study provides numerous points to ponder about the treatment of leukemia in Brazil. The percentage of patients classified as high risk in our sample was higher than that reported in the international literature. This difference, however, had no impact on overall survival, which was shorter than that reported in the international literature. |
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Silva, Klerize Anecely de SouzaRechenmacher, CilianaMorais, Rahuany Velleda deMichalowski, Mariana BohnsDaudt, Liane Esteves2021-12-29T04:27:40Z20212357-9730http://hdl.handle.net/10183/233491001134241Introduction: Treatment of childhood acute lymphoblastic leukemia (ALL) is based on risk stratification. This study aimed to assess the agreement between risk group classifications in the different childhood ALL treatment protocols used in a referral hospital in southern Brazil. Methods: We retrospectively reviewed the medical records of patients aged 1 to 18 years with B-cell ALL treated at a hospital from January 2013 to April 2017. Agreement between risk classifications was assessed by the kappa coefficient. Results: Seventy-five patients were analyzed. There was poor agreement between risk stratification by GBTLI 2009 and BFM 95 protocols (kappa=0.22; p = 0.003) and by GBTLI 2009 and IC-BFM 2002 protocols (kappa=0.24; p = 0.002). Risk group distribution was 13.3% for low risk, 32.0% for intermediate risk, and 54.7% for high risk based on stratification by the GBTLI 2009 protocol, and 28.0% for low risk, 42.7% for intermediate risk, and 29.3% for high risk based on stratification by the IC-BFM 2002 protocol. Overall survival was 68.6%. Conclusion: This study provides numerous points to ponder about the treatment of leukemia in Brazil. The percentage of patients classified as high risk in our sample was higher than that reported in the international literature. This difference, however, had no impact on overall survival, which was shorter than that reported in the international literature.application/pdfengClinical and biomedical research. Porto Alegre. Vol. 41, no. 3 (2021), p. 192-198Leucemia-linfoma linfoblástico de células precursorasFatores de riscoImunofenotipagemNeoplasia residualChildhood ALLRisk factorsImmunophenotypingMinimal residual diseaseAre there regional variations in the presentation of childhood leukemia?info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001134241.pdf.txt001134241.pdf.txtExtracted Texttext/plain27372http://www.lume.ufrgs.br/bitstream/10183/233491/2/001134241.pdf.txt885efd33e40623ace5dcb078e922464fMD52ORIGINAL001134241.pdfTexto completo (inglês)application/pdf331072http://www.lume.ufrgs.br/bitstream/10183/233491/1/001134241.pdf777c14efa11b68541fa02c3a9dfb197fMD5110183/2334912022-01-07 05:33:00.905933oai:www.lume.ufrgs.br:10183/233491Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-01-07T07:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Are there regional variations in the presentation of childhood leukemia? |
title |
Are there regional variations in the presentation of childhood leukemia? |
spellingShingle |
Are there regional variations in the presentation of childhood leukemia? Silva, Klerize Anecely de Souza Leucemia-linfoma linfoblástico de células precursoras Fatores de risco Imunofenotipagem Neoplasia residual Childhood ALL Risk factors Immunophenotyping Minimal residual disease |
title_short |
Are there regional variations in the presentation of childhood leukemia? |
title_full |
Are there regional variations in the presentation of childhood leukemia? |
title_fullStr |
Are there regional variations in the presentation of childhood leukemia? |
title_full_unstemmed |
Are there regional variations in the presentation of childhood leukemia? |
title_sort |
Are there regional variations in the presentation of childhood leukemia? |
author |
Silva, Klerize Anecely de Souza |
author_facet |
Silva, Klerize Anecely de Souza Rechenmacher, Ciliana Morais, Rahuany Velleda de Michalowski, Mariana Bohns Daudt, Liane Esteves |
author_role |
author |
author2 |
Rechenmacher, Ciliana Morais, Rahuany Velleda de Michalowski, Mariana Bohns Daudt, Liane Esteves |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva, Klerize Anecely de Souza Rechenmacher, Ciliana Morais, Rahuany Velleda de Michalowski, Mariana Bohns Daudt, Liane Esteves |
dc.subject.por.fl_str_mv |
Leucemia-linfoma linfoblástico de células precursoras Fatores de risco Imunofenotipagem Neoplasia residual |
topic |
Leucemia-linfoma linfoblástico de células precursoras Fatores de risco Imunofenotipagem Neoplasia residual Childhood ALL Risk factors Immunophenotyping Minimal residual disease |
dc.subject.eng.fl_str_mv |
Childhood ALL Risk factors Immunophenotyping Minimal residual disease |
description |
Introduction: Treatment of childhood acute lymphoblastic leukemia (ALL) is based on risk stratification. This study aimed to assess the agreement between risk group classifications in the different childhood ALL treatment protocols used in a referral hospital in southern Brazil. Methods: We retrospectively reviewed the medical records of patients aged 1 to 18 years with B-cell ALL treated at a hospital from January 2013 to April 2017. Agreement between risk classifications was assessed by the kappa coefficient. Results: Seventy-five patients were analyzed. There was poor agreement between risk stratification by GBTLI 2009 and BFM 95 protocols (kappa=0.22; p = 0.003) and by GBTLI 2009 and IC-BFM 2002 protocols (kappa=0.24; p = 0.002). Risk group distribution was 13.3% for low risk, 32.0% for intermediate risk, and 54.7% for high risk based on stratification by the GBTLI 2009 protocol, and 28.0% for low risk, 42.7% for intermediate risk, and 29.3% for high risk based on stratification by the IC-BFM 2002 protocol. Overall survival was 68.6%. Conclusion: This study provides numerous points to ponder about the treatment of leukemia in Brazil. The percentage of patients classified as high risk in our sample was higher than that reported in the international literature. This difference, however, had no impact on overall survival, which was shorter than that reported in the international literature. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-12-29T04:27:40Z |
dc.date.issued.fl_str_mv |
2021 |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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http://hdl.handle.net/10183/233491 |
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2357-9730 |
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001134241 |
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http://hdl.handle.net/10183/233491 |
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eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Clinical and biomedical research. Porto Alegre. Vol. 41, no. 3 (2021), p. 192-198 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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