Screening of hydroxyapatite biomaterials for alveolar augmentation using a rat calvaria critical-size defect model : bone formation/maturation and biomaterials resolution
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/256515 |
Resumo: | Background: Natural (bovine-/equine-/porcine-derived) or synthetic hydroxyapatite (HA) biomaterials appear to be the preferred technologies among clinicians for bone augmentation procedures in preparation for implant dentistry. The aim of this study was to screen candidate HA biomaterials intended for alveolar ridge augmentation relative to their potential to support local bone formation/maturation and to assess biomaterial resorption using a routine critical-size rat calvaria defect model. Methods: Eighty adult male Sprague Dawley outbred rats obtained from a approvedbreeder, randomized into groups of ten, were used. The calvaria defects (ø8 mm) either received sham surgery (empty control), Bio-Oss (bovine HA/reference control), or candidate biomaterials including bovine HA (Cerabone, DirectOss, 403Z013), and bovine (403Z014) or synthetic HA/ß-TCP (Reprobone, Ceraball) constructs. An 8 wk healing interval was used to capture the biomaterials’ resolution. Results: All biomaterials displayed biocompatibility. Strict HA biomaterials showed limited, if any, signs of biodegradation/resorption, with the biomaterial area fraction ranging from 22% to 42%. Synthetic HA/ß-TCP constructs showed limited evidence of biodegradation/erosion (biomaterial area fraction ≈30%). Mean linear defect closure in the sham-surgery control approximated 40%. Mean linear defect closure for the Bio-Oss reference control approximated 18% compared with 15–35% for the candidate biomaterials without significant differences between the controls and candidate biomaterials. Conclusions: None of the candidate HA biomaterials supported local bone formation/maturation beyond the native regenerative potential of this rodent model, pointing to their limitations for regenerative procedures. Biocompatibility and biomaterial dimensional stability could suggest their potential utility as long-term defect fillers. |
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Susin, CristianoLee, JaebumFiorini, TiagoKoo, Ki-TaeSchüpbach, PeterStadler, Amanda FingerWikesjö, Ulf Me2023-03-30T03:23:59Z20222218-273Xhttp://hdl.handle.net/10183/256515001163857Background: Natural (bovine-/equine-/porcine-derived) or synthetic hydroxyapatite (HA) biomaterials appear to be the preferred technologies among clinicians for bone augmentation procedures in preparation for implant dentistry. The aim of this study was to screen candidate HA biomaterials intended for alveolar ridge augmentation relative to their potential to support local bone formation/maturation and to assess biomaterial resorption using a routine critical-size rat calvaria defect model. Methods: Eighty adult male Sprague Dawley outbred rats obtained from a approvedbreeder, randomized into groups of ten, were used. The calvaria defects (ø8 mm) either received sham surgery (empty control), Bio-Oss (bovine HA/reference control), or candidate biomaterials including bovine HA (Cerabone, DirectOss, 403Z013), and bovine (403Z014) or synthetic HA/ß-TCP (Reprobone, Ceraball) constructs. An 8 wk healing interval was used to capture the biomaterials’ resolution. Results: All biomaterials displayed biocompatibility. Strict HA biomaterials showed limited, if any, signs of biodegradation/resorption, with the biomaterial area fraction ranging from 22% to 42%. Synthetic HA/ß-TCP constructs showed limited evidence of biodegradation/erosion (biomaterial area fraction ≈30%). Mean linear defect closure in the sham-surgery control approximated 40%. Mean linear defect closure for the Bio-Oss reference control approximated 18% compared with 15–35% for the candidate biomaterials without significant differences between the controls and candidate biomaterials. Conclusions: None of the candidate HA biomaterials supported local bone formation/maturation beyond the native regenerative potential of this rodent model, pointing to their limitations for regenerative procedures. Biocompatibility and biomaterial dimensional stability could suggest their potential utility as long-term defect fillers.application/pdfengBiomolecules. Basel. Vol. 12, n. 11 (2022), 1677, 10 p.Substitutos ósseosDurapatitaBiocompatible materialsBoneAlveolar bone graftingScreening of hydroxyapatite biomaterials for alveolar augmentation using a rat calvaria critical-size defect model : bone formation/maturation and biomaterials resolutionEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001163857.pdf.txt001163857.pdf.txtExtracted Texttext/plain40827http://www.lume.ufrgs.br/bitstream/10183/256515/2/001163857.pdf.txt3cf9df1444cc3059da021b92ea044e80MD52ORIGINAL001163857.pdfTexto completo (inglês)application/pdf595754http://www.lume.ufrgs.br/bitstream/10183/256515/1/001163857.pdfe86baa22296b1b1c67f4b54a4ee51011MD5110183/2565152023-08-09 03:48:49.940664oai:www.lume.ufrgs.br:10183/256515Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-09T06:48:49Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Screening of hydroxyapatite biomaterials for alveolar augmentation using a rat calvaria critical-size defect model : bone formation/maturation and biomaterials resolution |
title |
Screening of hydroxyapatite biomaterials for alveolar augmentation using a rat calvaria critical-size defect model : bone formation/maturation and biomaterials resolution |
spellingShingle |
Screening of hydroxyapatite biomaterials for alveolar augmentation using a rat calvaria critical-size defect model : bone formation/maturation and biomaterials resolution Susin, Cristiano Substitutos ósseos Durapatita Biocompatible materials Bone Alveolar bone grafting |
title_short |
Screening of hydroxyapatite biomaterials for alveolar augmentation using a rat calvaria critical-size defect model : bone formation/maturation and biomaterials resolution |
title_full |
Screening of hydroxyapatite biomaterials for alveolar augmentation using a rat calvaria critical-size defect model : bone formation/maturation and biomaterials resolution |
title_fullStr |
Screening of hydroxyapatite biomaterials for alveolar augmentation using a rat calvaria critical-size defect model : bone formation/maturation and biomaterials resolution |
title_full_unstemmed |
Screening of hydroxyapatite biomaterials for alveolar augmentation using a rat calvaria critical-size defect model : bone formation/maturation and biomaterials resolution |
title_sort |
Screening of hydroxyapatite biomaterials for alveolar augmentation using a rat calvaria critical-size defect model : bone formation/maturation and biomaterials resolution |
author |
Susin, Cristiano |
author_facet |
Susin, Cristiano Lee, Jaebum Fiorini, Tiago Koo, Ki-Tae Schüpbach, Peter Stadler, Amanda Finger Wikesjö, Ulf Me |
author_role |
author |
author2 |
Lee, Jaebum Fiorini, Tiago Koo, Ki-Tae Schüpbach, Peter Stadler, Amanda Finger Wikesjö, Ulf Me |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Susin, Cristiano Lee, Jaebum Fiorini, Tiago Koo, Ki-Tae Schüpbach, Peter Stadler, Amanda Finger Wikesjö, Ulf Me |
dc.subject.por.fl_str_mv |
Substitutos ósseos Durapatita |
topic |
Substitutos ósseos Durapatita Biocompatible materials Bone Alveolar bone grafting |
dc.subject.eng.fl_str_mv |
Biocompatible materials Bone Alveolar bone grafting |
description |
Background: Natural (bovine-/equine-/porcine-derived) or synthetic hydroxyapatite (HA) biomaterials appear to be the preferred technologies among clinicians for bone augmentation procedures in preparation for implant dentistry. The aim of this study was to screen candidate HA biomaterials intended for alveolar ridge augmentation relative to their potential to support local bone formation/maturation and to assess biomaterial resorption using a routine critical-size rat calvaria defect model. Methods: Eighty adult male Sprague Dawley outbred rats obtained from a approvedbreeder, randomized into groups of ten, were used. The calvaria defects (ø8 mm) either received sham surgery (empty control), Bio-Oss (bovine HA/reference control), or candidate biomaterials including bovine HA (Cerabone, DirectOss, 403Z013), and bovine (403Z014) or synthetic HA/ß-TCP (Reprobone, Ceraball) constructs. An 8 wk healing interval was used to capture the biomaterials’ resolution. Results: All biomaterials displayed biocompatibility. Strict HA biomaterials showed limited, if any, signs of biodegradation/resorption, with the biomaterial area fraction ranging from 22% to 42%. Synthetic HA/ß-TCP constructs showed limited evidence of biodegradation/erosion (biomaterial area fraction ≈30%). Mean linear defect closure in the sham-surgery control approximated 40%. Mean linear defect closure for the Bio-Oss reference control approximated 18% compared with 15–35% for the candidate biomaterials without significant differences between the controls and candidate biomaterials. Conclusions: None of the candidate HA biomaterials supported local bone formation/maturation beyond the native regenerative potential of this rodent model, pointing to their limitations for regenerative procedures. Biocompatibility and biomaterial dimensional stability could suggest their potential utility as long-term defect fillers. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
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2023-03-30T03:23:59Z |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/256515 |
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2218-273X |
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001163857 |
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eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Biomolecules. Basel. Vol. 12, n. 11 (2022), 1677, 10 p. |
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