Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/218299 |
Resumo: | In the present study we investigated the action of vitamins E and C on the inhibition of acetylcholinesterase and butyrylcholinesterase activities provoked by arginine in cerebral cortex and serum of 60-day-old rats. Animals were pretreated for 1 week with daily intraperitoneal administration of saline (control) or vitamins E (40 mg/kg) and C (100 mg/kg). Twelve hours after the last injection, animals received one injection of arginine (0.8 M/g of body weight) or saline. Results showed that acetylcholinesterase and butyrylcholinesterase activities were decreased in the arginine-treated rats. Furthermore, pretreatment with vitamins E and C prevented these effects. The data indicate that the reduction of acetylcholinesterase and butyrylcholinesterase activities caused by arginine was probably mediated by oxidative stress. Assuming the possibility that these effects might also occur in the human condition, our findings may be relevant to explain, at least in part, the neurological dysfunction associated with hyperargininemia and might support a novel therapeutic strategy to slow the progression of neurodegeneration in this disorder. |
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Wyse, Angela Terezinha de SouzaStefanello, Francieli MoroChiarani, FabriaDelwing, DéboraWannmacher, Clovis Milton DuvalWajner, Moacir2021-03-02T04:15:40Z20040364-3190http://hdl.handle.net/10183/218299000503522In the present study we investigated the action of vitamins E and C on the inhibition of acetylcholinesterase and butyrylcholinesterase activities provoked by arginine in cerebral cortex and serum of 60-day-old rats. Animals were pretreated for 1 week with daily intraperitoneal administration of saline (control) or vitamins E (40 mg/kg) and C (100 mg/kg). Twelve hours after the last injection, animals received one injection of arginine (0.8 M/g of body weight) or saline. Results showed that acetylcholinesterase and butyrylcholinesterase activities were decreased in the arginine-treated rats. Furthermore, pretreatment with vitamins E and C prevented these effects. The data indicate that the reduction of acetylcholinesterase and butyrylcholinesterase activities caused by arginine was probably mediated by oxidative stress. Assuming the possibility that these effects might also occur in the human condition, our findings may be relevant to explain, at least in part, the neurological dysfunction associated with hyperargininemia and might support a novel therapeutic strategy to slow the progression of neurodegeneration in this disorder.application/pdfengNeurochemical research. New York, NY. Vol. 29, no. 2 (2004), p. 385-389HiperargininemiaAcetilcolinesteraseButirilcolinesteraseArgininaVitamina EÁcido ascórbicoHyperargininemiaAcetylcholinesteraseButyrylcholinesteraseArginineVitamin EVitamin CArginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress inductionEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000503522.pdf.txt000503522.pdf.txtExtracted Texttext/plain0http://www.lume.ufrgs.br/bitstream/10183/218299/2/000503522.pdf.txtd41d8cd98f00b204e9800998ecf8427eMD52ORIGINAL000503522.pdfTexto completo (inglês)application/pdf1528730http://www.lume.ufrgs.br/bitstream/10183/218299/1/000503522.pdf132db6cdd22e424f07ba48a25ee16f8dMD5110183/2182992021-04-12 08:31:21.50767oai:www.lume.ufrgs.br:10183/218299Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-04-12T11:31:21Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction |
title |
Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction |
spellingShingle |
Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction Wyse, Angela Terezinha de Souza Hiperargininemia Acetilcolinesterase Butirilcolinesterase Arginina Vitamina E Ácido ascórbico Hyperargininemia Acetylcholinesterase Butyrylcholinesterase Arginine Vitamin E Vitamin C |
title_short |
Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction |
title_full |
Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction |
title_fullStr |
Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction |
title_full_unstemmed |
Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction |
title_sort |
Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction |
author |
Wyse, Angela Terezinha de Souza |
author_facet |
Wyse, Angela Terezinha de Souza Stefanello, Francieli Moro Chiarani, Fabria Delwing, Débora Wannmacher, Clovis Milton Duval Wajner, Moacir |
author_role |
author |
author2 |
Stefanello, Francieli Moro Chiarani, Fabria Delwing, Débora Wannmacher, Clovis Milton Duval Wajner, Moacir |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Wyse, Angela Terezinha de Souza Stefanello, Francieli Moro Chiarani, Fabria Delwing, Débora Wannmacher, Clovis Milton Duval Wajner, Moacir |
dc.subject.por.fl_str_mv |
Hiperargininemia Acetilcolinesterase Butirilcolinesterase Arginina Vitamina E Ácido ascórbico |
topic |
Hiperargininemia Acetilcolinesterase Butirilcolinesterase Arginina Vitamina E Ácido ascórbico Hyperargininemia Acetylcholinesterase Butyrylcholinesterase Arginine Vitamin E Vitamin C |
dc.subject.eng.fl_str_mv |
Hyperargininemia Acetylcholinesterase Butyrylcholinesterase Arginine Vitamin E Vitamin C |
description |
In the present study we investigated the action of vitamins E and C on the inhibition of acetylcholinesterase and butyrylcholinesterase activities provoked by arginine in cerebral cortex and serum of 60-day-old rats. Animals were pretreated for 1 week with daily intraperitoneal administration of saline (control) or vitamins E (40 mg/kg) and C (100 mg/kg). Twelve hours after the last injection, animals received one injection of arginine (0.8 M/g of body weight) or saline. Results showed that acetylcholinesterase and butyrylcholinesterase activities were decreased in the arginine-treated rats. Furthermore, pretreatment with vitamins E and C prevented these effects. The data indicate that the reduction of acetylcholinesterase and butyrylcholinesterase activities caused by arginine was probably mediated by oxidative stress. Assuming the possibility that these effects might also occur in the human condition, our findings may be relevant to explain, at least in part, the neurological dysfunction associated with hyperargininemia and might support a novel therapeutic strategy to slow the progression of neurodegeneration in this disorder. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2021-03-02T04:15:40Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/218299 |
dc.identifier.issn.pt_BR.fl_str_mv |
0364-3190 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000503522 |
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0364-3190 000503522 |
url |
http://hdl.handle.net/10183/218299 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Neurochemical research. New York, NY. Vol. 29, no. 2 (2004), p. 385-389 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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