Glutamate and synaptic plasticity systems and smoking behavior : results from a genetic association study
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/225312 |
Resumo: | Smoking behavior is a multifactorial phenotype with significant heritability. Identifying the specific loci that influence smoking behavior could provide important etiological insights and facilitate the development of treatments to further reduce smoking related mortality. Although several studies pointed to different candidate genes for smoking, there is still a need for replication especially in samples from different countries. In the present study, we investigated whether 21 positive signals for smoking behavior from these studies are replicated in a sample of 531 blood donors from the Brazilian population. The polymorphisms were chosen based on their representativeness of different candidate biologic systems, strength of previous evidence, location and allele frequencies. By genotyping with the Sequenom MassARRAY iPLEX platform and subsequent statistical analysis using Plink software, we show that two of the SNPs studied, in the SLC1A2 (rs1083658) and ACTN1 (rs2268983) genes, were associated with smoking behavior in our study population. These genes are involved in crucial aspects of nicotine dependence, glutamate system and synaptic plasticity, and as such, are biologically plausible candidates that merit further molecular analyses so as to clarify their potential role in smoking behavior. |
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Santos, Vanessa Argondizo dosChatkin, Jose MiguelBau, Claiton Henrique DottoPaixão Côrtes, Vanessa RodriguesSun, YeZamel, NoeSiminovitch, Katherine2021-08-06T04:42:38Z20121932-6203http://hdl.handle.net/10183/225312000895000Smoking behavior is a multifactorial phenotype with significant heritability. Identifying the specific loci that influence smoking behavior could provide important etiological insights and facilitate the development of treatments to further reduce smoking related mortality. Although several studies pointed to different candidate genes for smoking, there is still a need for replication especially in samples from different countries. In the present study, we investigated whether 21 positive signals for smoking behavior from these studies are replicated in a sample of 531 blood donors from the Brazilian population. The polymorphisms were chosen based on their representativeness of different candidate biologic systems, strength of previous evidence, location and allele frequencies. By genotyping with the Sequenom MassARRAY iPLEX platform and subsequent statistical analysis using Plink software, we show that two of the SNPs studied, in the SLC1A2 (rs1083658) and ACTN1 (rs2268983) genes, were associated with smoking behavior in our study population. These genes are involved in crucial aspects of nicotine dependence, glutamate system and synaptic plasticity, and as such, are biologically plausible candidates that merit further molecular analyses so as to clarify their potential role in smoking behavior.application/pdfengPLoS ONE. San Francisco. Vol. 7, no. 6 (June 2012), e38666, 5 p.Ácido glutâmicoSinapseTabagismoGenética humanaGlutamate and synaptic plasticity systems and smoking behavior : results from a genetic association studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000895000.pdf.txt000895000.pdf.txtExtracted Texttext/plain27576http://www.lume.ufrgs.br/bitstream/10183/225312/2/000895000.pdf.txt23c1ffb6cf94b0ae985c3903c5bceec5MD52ORIGINAL000895000.pdfTexto completo (inglês)application/pdf484527http://www.lume.ufrgs.br/bitstream/10183/225312/1/000895000.pdfa5c0352b039428aca9c4f8dc6eab6d19MD5110183/2253122023-09-23 03:37:51.822433oai:www.lume.ufrgs.br:10183/225312Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-23T06:37:51Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Glutamate and synaptic plasticity systems and smoking behavior : results from a genetic association study |
title |
Glutamate and synaptic plasticity systems and smoking behavior : results from a genetic association study |
spellingShingle |
Glutamate and synaptic plasticity systems and smoking behavior : results from a genetic association study Santos, Vanessa Argondizo dos Ácido glutâmico Sinapse Tabagismo Genética humana |
title_short |
Glutamate and synaptic plasticity systems and smoking behavior : results from a genetic association study |
title_full |
Glutamate and synaptic plasticity systems and smoking behavior : results from a genetic association study |
title_fullStr |
Glutamate and synaptic plasticity systems and smoking behavior : results from a genetic association study |
title_full_unstemmed |
Glutamate and synaptic plasticity systems and smoking behavior : results from a genetic association study |
title_sort |
Glutamate and synaptic plasticity systems and smoking behavior : results from a genetic association study |
author |
Santos, Vanessa Argondizo dos |
author_facet |
Santos, Vanessa Argondizo dos Chatkin, Jose Miguel Bau, Claiton Henrique Dotto Paixão Côrtes, Vanessa Rodrigues Sun, Ye Zamel, Noe Siminovitch, Katherine |
author_role |
author |
author2 |
Chatkin, Jose Miguel Bau, Claiton Henrique Dotto Paixão Côrtes, Vanessa Rodrigues Sun, Ye Zamel, Noe Siminovitch, Katherine |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Vanessa Argondizo dos Chatkin, Jose Miguel Bau, Claiton Henrique Dotto Paixão Côrtes, Vanessa Rodrigues Sun, Ye Zamel, Noe Siminovitch, Katherine |
dc.subject.por.fl_str_mv |
Ácido glutâmico Sinapse Tabagismo Genética humana |
topic |
Ácido glutâmico Sinapse Tabagismo Genética humana |
description |
Smoking behavior is a multifactorial phenotype with significant heritability. Identifying the specific loci that influence smoking behavior could provide important etiological insights and facilitate the development of treatments to further reduce smoking related mortality. Although several studies pointed to different candidate genes for smoking, there is still a need for replication especially in samples from different countries. In the present study, we investigated whether 21 positive signals for smoking behavior from these studies are replicated in a sample of 531 blood donors from the Brazilian population. The polymorphisms were chosen based on their representativeness of different candidate biologic systems, strength of previous evidence, location and allele frequencies. By genotyping with the Sequenom MassARRAY iPLEX platform and subsequent statistical analysis using Plink software, we show that two of the SNPs studied, in the SLC1A2 (rs1083658) and ACTN1 (rs2268983) genes, were associated with smoking behavior in our study population. These genes are involved in crucial aspects of nicotine dependence, glutamate system and synaptic plasticity, and as such, are biologically plausible candidates that merit further molecular analyses so as to clarify their potential role in smoking behavior. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2021-08-06T04:42:38Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/225312 |
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1932-6203 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000895000 |
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1932-6203 000895000 |
url |
http://hdl.handle.net/10183/225312 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PLoS ONE. San Francisco. Vol. 7, no. 6 (June 2012), e38666, 5 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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