Impact on pregnancies in South Brazil from the influenza A (H1N1) pandemic : cohort study

Detalhes bibliográficos
Autor(a) principal: Silva, André Anjos da
Data de Publicação: 2014
Outros Autores: Ranieri, Tani Schilling, Torres, Fernanda Duarte, Sales, Fernando, Vianna, Luiz, Paniz, Graziella Rangel, Sanseverino, Paula Baptista, Picon, Paulo Dornelles, Azevedo, Pietro Baptista de, Costa, Marta Haas, Faccini, Lavinia Schuler, Sanseverino, Maria Teresa Vieira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/193982
Resumo: Introduction: The emergence of a new subtype of the influenza virus in 2009 generated interest in the international medical community, the media, and the general population. Pregnant women are considered to be a group at risk of serious complications related to the H1N1 influenza virus. The aim of this study was to evaluate the outcomes and teratogenic effects of pregnancies exposed to the H1N1 virus during the Influenza A epidemic that occurred in the state of Rio Grande do Sul in 2009. Methods: This is an uncontrolled prospective cohort study of pregnant women with suspected symptoms of Influenza A who were reported in the Information System for Notifiable Diseases – Influenza (SINAN-Influenza) during the epidemic of 2009 (database from the state of Rio Grande do Sul, Brazil). There were 589 cases of pregnant women with suspected infection. Among these, 243 were tested by PCR and included in the analysis. The main outcome measures were: maternal deaths, pregnancy outcome, stillbirths, premature births, low birth weight, congenital malformations, and odds ratios for H1N1+ and non-H1N1 pregnant women. Results: There were one hundred and sixty-three (67%) confirmed cases of H1N1, 34 cases (14%) of seasonal Influenza A and 46 (19%) who were negative for Influenza A. There was no difference between the three groups in clinical parameters of the disease. There were 24 maternal deaths — 18 of them had H1N1. There were 8 stillbirths — 5 were children of H1N1 infected mothers. There were no differences in perinatal outcomes. Conclusions: The present data do not indicate an increase in teratogenic risk from exposure to the influenza A (H1N1) virus. These results will help to strengthen the data and clarify the health issues that arose after the pandemic.
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spelling Silva, André Anjos daRanieri, Tani SchillingTorres, Fernanda DuarteSales, FernandoVianna, LuizPaniz, Graziella RangelSanseverino, Paula BaptistaPicon, Paulo DornellesAzevedo, Pietro Baptista deCosta, Marta HaasFaccini, Lavinia SchulerSanseverino, Maria Teresa Vieira2019-05-08T02:34:50Z20141932-6203http://hdl.handle.net/10183/193982000953899Introduction: The emergence of a new subtype of the influenza virus in 2009 generated interest in the international medical community, the media, and the general population. Pregnant women are considered to be a group at risk of serious complications related to the H1N1 influenza virus. The aim of this study was to evaluate the outcomes and teratogenic effects of pregnancies exposed to the H1N1 virus during the Influenza A epidemic that occurred in the state of Rio Grande do Sul in 2009. Methods: This is an uncontrolled prospective cohort study of pregnant women with suspected symptoms of Influenza A who were reported in the Information System for Notifiable Diseases – Influenza (SINAN-Influenza) during the epidemic of 2009 (database from the state of Rio Grande do Sul, Brazil). There were 589 cases of pregnant women with suspected infection. Among these, 243 were tested by PCR and included in the analysis. The main outcome measures were: maternal deaths, pregnancy outcome, stillbirths, premature births, low birth weight, congenital malformations, and odds ratios for H1N1+ and non-H1N1 pregnant women. Results: There were one hundred and sixty-three (67%) confirmed cases of H1N1, 34 cases (14%) of seasonal Influenza A and 46 (19%) who were negative for Influenza A. There was no difference between the three groups in clinical parameters of the disease. There were 24 maternal deaths — 18 of them had H1N1. There were 8 stillbirths — 5 were children of H1N1 infected mothers. There were no differences in perinatal outcomes. Conclusions: The present data do not indicate an increase in teratogenic risk from exposure to the influenza A (H1N1) virus. These results will help to strengthen the data and clarify the health issues that arose after the pandemic.application/pdfengPLoS ONE. San Francisco. Vol. 9, no. 2 (Feb. 2014), e88624, 6 p.GravidezVírus da influenza A subtipo H1N1PandemiasEstudos de coortesImpact on pregnancies in South Brazil from the influenza A (H1N1) pandemic : cohort studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000953899.pdf.txt000953899.pdf.txtExtracted Texttext/plain32402http://www.lume.ufrgs.br/bitstream/10183/193982/2/000953899.pdf.txt70427a9501b2cc4efb19a61c92a12e5fMD52ORIGINAL000953899.pdfTexto completo (inglês)application/pdf503512http://www.lume.ufrgs.br/bitstream/10183/193982/1/000953899.pdf22d4c201f078451f9b16cacf542b7522MD5110183/1939822023-09-23 03:37:24.586411oai:www.lume.ufrgs.br:10183/193982Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-23T06:37:24Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Impact on pregnancies in South Brazil from the influenza A (H1N1) pandemic : cohort study
title Impact on pregnancies in South Brazil from the influenza A (H1N1) pandemic : cohort study
spellingShingle Impact on pregnancies in South Brazil from the influenza A (H1N1) pandemic : cohort study
Silva, André Anjos da
Gravidez
Vírus da influenza A subtipo H1N1
Pandemias
Estudos de coortes
title_short Impact on pregnancies in South Brazil from the influenza A (H1N1) pandemic : cohort study
title_full Impact on pregnancies in South Brazil from the influenza A (H1N1) pandemic : cohort study
title_fullStr Impact on pregnancies in South Brazil from the influenza A (H1N1) pandemic : cohort study
title_full_unstemmed Impact on pregnancies in South Brazil from the influenza A (H1N1) pandemic : cohort study
title_sort Impact on pregnancies in South Brazil from the influenza A (H1N1) pandemic : cohort study
author Silva, André Anjos da
author_facet Silva, André Anjos da
Ranieri, Tani Schilling
Torres, Fernanda Duarte
Sales, Fernando
Vianna, Luiz
Paniz, Graziella Rangel
Sanseverino, Paula Baptista
Picon, Paulo Dornelles
Azevedo, Pietro Baptista de
Costa, Marta Haas
Faccini, Lavinia Schuler
Sanseverino, Maria Teresa Vieira
author_role author
author2 Ranieri, Tani Schilling
Torres, Fernanda Duarte
Sales, Fernando
Vianna, Luiz
Paniz, Graziella Rangel
Sanseverino, Paula Baptista
Picon, Paulo Dornelles
Azevedo, Pietro Baptista de
Costa, Marta Haas
Faccini, Lavinia Schuler
Sanseverino, Maria Teresa Vieira
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, André Anjos da
Ranieri, Tani Schilling
Torres, Fernanda Duarte
Sales, Fernando
Vianna, Luiz
Paniz, Graziella Rangel
Sanseverino, Paula Baptista
Picon, Paulo Dornelles
Azevedo, Pietro Baptista de
Costa, Marta Haas
Faccini, Lavinia Schuler
Sanseverino, Maria Teresa Vieira
dc.subject.por.fl_str_mv Gravidez
Vírus da influenza A subtipo H1N1
Pandemias
Estudos de coortes
topic Gravidez
Vírus da influenza A subtipo H1N1
Pandemias
Estudos de coortes
description Introduction: The emergence of a new subtype of the influenza virus in 2009 generated interest in the international medical community, the media, and the general population. Pregnant women are considered to be a group at risk of serious complications related to the H1N1 influenza virus. The aim of this study was to evaluate the outcomes and teratogenic effects of pregnancies exposed to the H1N1 virus during the Influenza A epidemic that occurred in the state of Rio Grande do Sul in 2009. Methods: This is an uncontrolled prospective cohort study of pregnant women with suspected symptoms of Influenza A who were reported in the Information System for Notifiable Diseases – Influenza (SINAN-Influenza) during the epidemic of 2009 (database from the state of Rio Grande do Sul, Brazil). There were 589 cases of pregnant women with suspected infection. Among these, 243 were tested by PCR and included in the analysis. The main outcome measures were: maternal deaths, pregnancy outcome, stillbirths, premature births, low birth weight, congenital malformations, and odds ratios for H1N1+ and non-H1N1 pregnant women. Results: There were one hundred and sixty-three (67%) confirmed cases of H1N1, 34 cases (14%) of seasonal Influenza A and 46 (19%) who were negative for Influenza A. There was no difference between the three groups in clinical parameters of the disease. There were 24 maternal deaths — 18 of them had H1N1. There were 8 stillbirths — 5 were children of H1N1 infected mothers. There were no differences in perinatal outcomes. Conclusions: The present data do not indicate an increase in teratogenic risk from exposure to the influenza A (H1N1) virus. These results will help to strengthen the data and clarify the health issues that arose after the pandemic.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2019-05-08T02:34:50Z
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dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.nrb.pt_BR.fl_str_mv 000953899
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url http://hdl.handle.net/10183/193982
dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv PLoS ONE. San Francisco. Vol. 9, no. 2 (Feb. 2014), e88624, 6 p.
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