Gene DRD4 e o uso de substâncias em adultos com TDAH
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/200522 |
Resumo: | Background: Most individuals with attention-deficit/hyperactivity disorder (ADHD) present one or more psychiatric comorbidities and substance use disorder (SUD) is one of the most frequent in adults. The dopaminergic system is related to the pathogenesis of externalizing disorders, which includes both ADHD and SUD. Thus, the aim of this study was to evaluate the effects of the 120 bp tandem duplication of the DRD4 gene in the susceptibility to ADHD in adults and to crack/cocaine addiction, as well as to evaluate the associated comorbidities in these two independent samples. Methods: The sample is composed by 555 adults with ADHD, 296 crack/cocaine addicts and 635 blood donors as control group. Association analysis for primary outcomes and comorbidities were performed using binary logistic regression. Results: Regarding susceptibility to ADHD and crack/cocaine addiction, we did not observe a significant association between the 120 bp duplication polymorphism and the disorders (p = 0.669, OR = 0.95; p = 0.559, OR = 1.167; respectively). However, evaluating the presence of comorbid SUD within the ADHD sample, it was observed that short allele carriers are at higher risk of developing SUD than homozygotes for the long allele (p = 0.023; OR = 1.679) and this effect was stronger for non-alcohol substance use (p = 0.010; OR = 2.085). Conclusion: Our results suggest that the short allele of the 120 bp tandem duplication of DRD4 gene influences the susceptibility to SUD when in simultaneous presence of ADHD. |
id |
UFRGS-2_5340ec4f645e88f2d356edbfd5e6865a |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/200522 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Winkler, CristinaBau, Claiton Henrique DottoSilva, Bruna Santos daKappel, Djenifer2019-10-11T03:55:25Z2016http://hdl.handle.net/10183/200522001027319Background: Most individuals with attention-deficit/hyperactivity disorder (ADHD) present one or more psychiatric comorbidities and substance use disorder (SUD) is one of the most frequent in adults. The dopaminergic system is related to the pathogenesis of externalizing disorders, which includes both ADHD and SUD. Thus, the aim of this study was to evaluate the effects of the 120 bp tandem duplication of the DRD4 gene in the susceptibility to ADHD in adults and to crack/cocaine addiction, as well as to evaluate the associated comorbidities in these two independent samples. Methods: The sample is composed by 555 adults with ADHD, 296 crack/cocaine addicts and 635 blood donors as control group. Association analysis for primary outcomes and comorbidities were performed using binary logistic regression. Results: Regarding susceptibility to ADHD and crack/cocaine addiction, we did not observe a significant association between the 120 bp duplication polymorphism and the disorders (p = 0.669, OR = 0.95; p = 0.559, OR = 1.167; respectively). However, evaluating the presence of comorbid SUD within the ADHD sample, it was observed that short allele carriers are at higher risk of developing SUD than homozygotes for the long allele (p = 0.023; OR = 1.679) and this effect was stronger for non-alcohol substance use (p = 0.010; OR = 2.085). Conclusion: Our results suggest that the short allele of the 120 bp tandem duplication of DRD4 gene influences the susceptibility to SUD when in simultaneous presence of ADHD.application/pdfengTranstorno da falta de atenção com hiperatividadeDrogas ilícitasCocaína crackReceptores de dopamina D4Attention-deficit/hyperactivity disorderAssociation analysis120 bp tandem duplication120 bp tandem duplicationDopamine D4 ReceptorCrack/cocaine addictionSubstance use disorderGene DRD4 e o uso de substâncias em adultos com TDAHinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisUniversidade Federal do Rio Grande do SulInstituto de BiociênciasPorto Alegre, BR-RS2016Ciências Biológicas: Bachareladograduaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001027319.pdf.txt001027319.pdf.txtExtracted Texttext/plain40027http://www.lume.ufrgs.br/bitstream/10183/200522/2/001027319.pdf.txt2e1cf8e518c02a77605fafa599d72ddaMD52ORIGINAL001027319.pdfTexto completo (inglês)application/pdf246879http://www.lume.ufrgs.br/bitstream/10183/200522/1/001027319.pdf1fd8c1716768cb6e7d8e45cc354913c3MD5110183/2005222024-03-13 05:05:22.568819oai:www.lume.ufrgs.br:10183/200522Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-03-13T08:05:22Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Gene DRD4 e o uso de substâncias em adultos com TDAH |
title |
Gene DRD4 e o uso de substâncias em adultos com TDAH |
spellingShingle |
Gene DRD4 e o uso de substâncias em adultos com TDAH Winkler, Cristina Transtorno da falta de atenção com hiperatividade Drogas ilícitas Cocaína crack Receptores de dopamina D4 Attention-deficit/hyperactivity disorder Association analysis 120 bp tandem duplication 120 bp tandem duplication Dopamine D4 Receptor Crack/cocaine addiction Substance use disorder |
title_short |
Gene DRD4 e o uso de substâncias em adultos com TDAH |
title_full |
Gene DRD4 e o uso de substâncias em adultos com TDAH |
title_fullStr |
Gene DRD4 e o uso de substâncias em adultos com TDAH |
title_full_unstemmed |
Gene DRD4 e o uso de substâncias em adultos com TDAH |
title_sort |
Gene DRD4 e o uso de substâncias em adultos com TDAH |
author |
Winkler, Cristina |
author_facet |
Winkler, Cristina |
author_role |
author |
dc.contributor.author.fl_str_mv |
Winkler, Cristina |
dc.contributor.advisor1.fl_str_mv |
Bau, Claiton Henrique Dotto |
dc.contributor.advisor-co1.fl_str_mv |
Silva, Bruna Santos da Kappel, Djenifer |
contributor_str_mv |
Bau, Claiton Henrique Dotto Silva, Bruna Santos da Kappel, Djenifer |
dc.subject.por.fl_str_mv |
Transtorno da falta de atenção com hiperatividade Drogas ilícitas Cocaína crack Receptores de dopamina D4 |
topic |
Transtorno da falta de atenção com hiperatividade Drogas ilícitas Cocaína crack Receptores de dopamina D4 Attention-deficit/hyperactivity disorder Association analysis 120 bp tandem duplication 120 bp tandem duplication Dopamine D4 Receptor Crack/cocaine addiction Substance use disorder |
dc.subject.eng.fl_str_mv |
Attention-deficit/hyperactivity disorder Association analysis 120 bp tandem duplication 120 bp tandem duplication Dopamine D4 Receptor Crack/cocaine addiction Substance use disorder |
description |
Background: Most individuals with attention-deficit/hyperactivity disorder (ADHD) present one or more psychiatric comorbidities and substance use disorder (SUD) is one of the most frequent in adults. The dopaminergic system is related to the pathogenesis of externalizing disorders, which includes both ADHD and SUD. Thus, the aim of this study was to evaluate the effects of the 120 bp tandem duplication of the DRD4 gene in the susceptibility to ADHD in adults and to crack/cocaine addiction, as well as to evaluate the associated comorbidities in these two independent samples. Methods: The sample is composed by 555 adults with ADHD, 296 crack/cocaine addicts and 635 blood donors as control group. Association analysis for primary outcomes and comorbidities were performed using binary logistic regression. Results: Regarding susceptibility to ADHD and crack/cocaine addiction, we did not observe a significant association between the 120 bp duplication polymorphism and the disorders (p = 0.669, OR = 0.95; p = 0.559, OR = 1.167; respectively). However, evaluating the presence of comorbid SUD within the ADHD sample, it was observed that short allele carriers are at higher risk of developing SUD than homozygotes for the long allele (p = 0.023; OR = 1.679) and this effect was stronger for non-alcohol substance use (p = 0.010; OR = 2.085). Conclusion: Our results suggest that the short allele of the 120 bp tandem duplication of DRD4 gene influences the susceptibility to SUD when in simultaneous presence of ADHD. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2019-10-11T03:55:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/200522 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001027319 |
url |
http://hdl.handle.net/10183/200522 |
identifier_str_mv |
001027319 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/200522/2/001027319.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/200522/1/001027319.pdf |
bitstream.checksum.fl_str_mv |
2e1cf8e518c02a77605fafa599d72dda 1fd8c1716768cb6e7d8e45cc354913c3 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224584989507584 |