Uv derivative spectrophotometric method for determination of estradiol valerate in tablets

Detalhes bibliográficos
Autor(a) principal: Mendez, Andreas Sebastian Loureiro
Data de Publicação: 2010
Outros Autores: Deconto, Lislaine, Garcia, Cassia Virginia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/72896
Resumo: A derivative UV spectrophotometric method for determination of estradiol valerate in tablets was validated. The parameters specificity, linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to validation guidelines. The first-order derivative spectra were obtained at N = 5, Δλ = 4.0 nm, and determinations were made at 270 nm. The method showed specificity and linearity in the concentration range of 0.20 to 0.40 mg mL-1. The intra and interday precision data demonstrated the method has good reproducibility. Accuracy was also evaluated and results were satisfactory. The proposed method was successfully applied to a pharmaceutical formulation.
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spelling Mendez, Andreas Sebastian LoureiroDeconto, LislaineGarcia, Cassia Virginia2013-07-02T01:43:27Z20100100-4042http://hdl.handle.net/10183/72896000793483A derivative UV spectrophotometric method for determination of estradiol valerate in tablets was validated. The parameters specificity, linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to validation guidelines. The first-order derivative spectra were obtained at N = 5, Δλ = 4.0 nm, and determinations were made at 270 nm. The method showed specificity and linearity in the concentration range of 0.20 to 0.40 mg mL-1. The intra and interday precision data demonstrated the method has good reproducibility. Accuracy was also evaluated and results were satisfactory. The proposed method was successfully applied to a pharmaceutical formulation.application/pdfengQuímica nova. São Paulo. Vol. 33, n. 4 (2010), p. 981-983EstradiolValidação : Métodos de análise de fármacosEspectrofotometria ultravioletaEstradiol valerateUV derivative spectrophotometric methodMethod validationUv derivative spectrophotometric method for determination of estradiol valerate in tabletsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000793483.pdf000793483.pdfTexto completo (inglês)application/pdf250110http://www.lume.ufrgs.br/bitstream/10183/72896/1/000793483.pdfe157d7c03c9f1ccc9aea9a1376b709b9MD51TEXT000793483.pdf.txt000793483.pdf.txtExtracted Texttext/plain15995http://www.lume.ufrgs.br/bitstream/10183/72896/2/000793483.pdf.txt4bc01278af40bb80e0c482af70a55a3dMD52THUMBNAIL000793483.pdf.jpg000793483.pdf.jpgGenerated Thumbnailimage/jpeg1964http://www.lume.ufrgs.br/bitstream/10183/72896/3/000793483.pdf.jpg4dec29690b7c96568f31f7539c537f7eMD5310183/728962018-10-15 07:55:37.16oai:www.lume.ufrgs.br:10183/72896Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-15T10:55:37Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Uv derivative spectrophotometric method for determination of estradiol valerate in tablets
title Uv derivative spectrophotometric method for determination of estradiol valerate in tablets
spellingShingle Uv derivative spectrophotometric method for determination of estradiol valerate in tablets
Mendez, Andreas Sebastian Loureiro
Estradiol
Validação : Métodos de análise de fármacos
Espectrofotometria ultravioleta
Estradiol valerate
UV derivative spectrophotometric method
Method validation
title_short Uv derivative spectrophotometric method for determination of estradiol valerate in tablets
title_full Uv derivative spectrophotometric method for determination of estradiol valerate in tablets
title_fullStr Uv derivative spectrophotometric method for determination of estradiol valerate in tablets
title_full_unstemmed Uv derivative spectrophotometric method for determination of estradiol valerate in tablets
title_sort Uv derivative spectrophotometric method for determination of estradiol valerate in tablets
author Mendez, Andreas Sebastian Loureiro
author_facet Mendez, Andreas Sebastian Loureiro
Deconto, Lislaine
Garcia, Cassia Virginia
author_role author
author2 Deconto, Lislaine
Garcia, Cassia Virginia
author2_role author
author
dc.contributor.author.fl_str_mv Mendez, Andreas Sebastian Loureiro
Deconto, Lislaine
Garcia, Cassia Virginia
dc.subject.por.fl_str_mv Estradiol
Validação : Métodos de análise de fármacos
Espectrofotometria ultravioleta
topic Estradiol
Validação : Métodos de análise de fármacos
Espectrofotometria ultravioleta
Estradiol valerate
UV derivative spectrophotometric method
Method validation
dc.subject.eng.fl_str_mv Estradiol valerate
UV derivative spectrophotometric method
Method validation
description A derivative UV spectrophotometric method for determination of estradiol valerate in tablets was validated. The parameters specificity, linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to validation guidelines. The first-order derivative spectra were obtained at N = 5, Δλ = 4.0 nm, and determinations were made at 270 nm. The method showed specificity and linearity in the concentration range of 0.20 to 0.40 mg mL-1. The intra and interday precision data demonstrated the method has good reproducibility. Accuracy was also evaluated and results were satisfactory. The proposed method was successfully applied to a pharmaceutical formulation.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-07-02T01:43:27Z
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dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo. Vol. 33, n. 4 (2010), p. 981-983
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