Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease : a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/149736 |
Resumo: | The potential association between the K121Q (A/C, rs1044498) polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) gene and risk of diabetic kidney disease (DKD) has been investigated. Nevertheless, the effect of this variant on DKD risk is still under debate, and conflicting results have been reported. To this date, no meta-analysis has evaluated the association of the K121Q polymorphism with DKD. This paper describes the first meta-analysis conducted to evaluate whether the ENPP1K121Q polymorphism is associated with DKD. A literature search was conducted to identify all case-control or crosssectional studies that evaluated associations between the ENPP1K121Q polymorphism and DKD. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for allele contrast, additive, dominant and recessive inheritance models. Seven studies were eligible for inclusion in the meta-analysis, providing data on 3571 type 1 or type 2 diabetic patients (1606 cases with DKD and 1965 diabetic controls without this complication). No significant heterogeneity was observed among the studies included in the meta-analysis when assuming different inheritance models (I² < 50% or P > 0.10 for the entire sample and after stratification by ethnicity). Meta-analysis results revealed significant associations between the K121Q polymorphism and risk of DKD in Asians and Europeans when assuming the different inheritance models analyzed. The most powerful association was observed for the additive model (OR = 1.74, 95% CI 1.27-2.38 for the total sample). In conclusion, the present meta-analysis detected a significant association between the ENPP1K121Q polymorphism and increased susceptibility of DKD in European and Asian populations. |
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Sortica, Denise AlvesBuffon, Marjoriê PiucoSouza, Bianca Marmontel deNicoletto, Bruna BellincantaSanter, AndressaAssmann, Taís SilveiraCrispim, DaisyCanani, Luis Henrique Santos2016-11-19T02:16:42Z20151932-6203http://hdl.handle.net/10183/149736000997336The potential association between the K121Q (A/C, rs1044498) polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) gene and risk of diabetic kidney disease (DKD) has been investigated. Nevertheless, the effect of this variant on DKD risk is still under debate, and conflicting results have been reported. To this date, no meta-analysis has evaluated the association of the K121Q polymorphism with DKD. This paper describes the first meta-analysis conducted to evaluate whether the ENPP1K121Q polymorphism is associated with DKD. A literature search was conducted to identify all case-control or crosssectional studies that evaluated associations between the ENPP1K121Q polymorphism and DKD. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for allele contrast, additive, dominant and recessive inheritance models. Seven studies were eligible for inclusion in the meta-analysis, providing data on 3571 type 1 or type 2 diabetic patients (1606 cases with DKD and 1965 diabetic controls without this complication). No significant heterogeneity was observed among the studies included in the meta-analysis when assuming different inheritance models (I² < 50% or P > 0.10 for the entire sample and after stratification by ethnicity). Meta-analysis results revealed significant associations between the K121Q polymorphism and risk of DKD in Asians and Europeans when assuming the different inheritance models analyzed. The most powerful association was observed for the additive model (OR = 1.74, 95% CI 1.27-2.38 for the total sample). In conclusion, the present meta-analysis detected a significant association between the ENPP1K121Q polymorphism and increased susceptibility of DKD in European and Asian populations.application/pdfengPLoS ONE. San Francisco. Vol. 10, no. 3 (Mar. 2015), e0118416, 15 p.Nefropatias diabéticasPolimorfismo genéticoMetanáliseAssociation between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease : a systematic review and meta-analysisEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000997336.pdf000997336.pdfTexto completo (inglês)application/pdf1207199http://www.lume.ufrgs.br/bitstream/10183/149736/1/000997336.pdf57e0fe653dfd086329a58ae26e644e46MD51TEXT000997336.pdf.txt000997336.pdf.txtExtracted Texttext/plain44215http://www.lume.ufrgs.br/bitstream/10183/149736/2/000997336.pdf.txt6b0adcb22e1683d87367c0688aec5e8fMD52THUMBNAIL000997336.pdf.jpg000997336.pdf.jpgGenerated Thumbnailimage/jpeg1967http://www.lume.ufrgs.br/bitstream/10183/149736/3/000997336.pdf.jpg4bfdb88fc5a1c1c885ce89459595986bMD5310183/1497362018-10-29 09:23:05.582oai:www.lume.ufrgs.br:10183/149736Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-29T12:23:05Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease : a systematic review and meta-analysis |
title |
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease : a systematic review and meta-analysis |
spellingShingle |
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease : a systematic review and meta-analysis Sortica, Denise Alves Nefropatias diabéticas Polimorfismo genético Metanálise |
title_short |
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease : a systematic review and meta-analysis |
title_full |
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease : a systematic review and meta-analysis |
title_fullStr |
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease : a systematic review and meta-analysis |
title_full_unstemmed |
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease : a systematic review and meta-analysis |
title_sort |
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease : a systematic review and meta-analysis |
author |
Sortica, Denise Alves |
author_facet |
Sortica, Denise Alves Buffon, Marjoriê Piuco Souza, Bianca Marmontel de Nicoletto, Bruna Bellincanta Santer, Andressa Assmann, Taís Silveira Crispim, Daisy Canani, Luis Henrique Santos |
author_role |
author |
author2 |
Buffon, Marjoriê Piuco Souza, Bianca Marmontel de Nicoletto, Bruna Bellincanta Santer, Andressa Assmann, Taís Silveira Crispim, Daisy Canani, Luis Henrique Santos |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Sortica, Denise Alves Buffon, Marjoriê Piuco Souza, Bianca Marmontel de Nicoletto, Bruna Bellincanta Santer, Andressa Assmann, Taís Silveira Crispim, Daisy Canani, Luis Henrique Santos |
dc.subject.por.fl_str_mv |
Nefropatias diabéticas Polimorfismo genético Metanálise |
topic |
Nefropatias diabéticas Polimorfismo genético Metanálise |
description |
The potential association between the K121Q (A/C, rs1044498) polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) gene and risk of diabetic kidney disease (DKD) has been investigated. Nevertheless, the effect of this variant on DKD risk is still under debate, and conflicting results have been reported. To this date, no meta-analysis has evaluated the association of the K121Q polymorphism with DKD. This paper describes the first meta-analysis conducted to evaluate whether the ENPP1K121Q polymorphism is associated with DKD. A literature search was conducted to identify all case-control or crosssectional studies that evaluated associations between the ENPP1K121Q polymorphism and DKD. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for allele contrast, additive, dominant and recessive inheritance models. Seven studies were eligible for inclusion in the meta-analysis, providing data on 3571 type 1 or type 2 diabetic patients (1606 cases with DKD and 1965 diabetic controls without this complication). No significant heterogeneity was observed among the studies included in the meta-analysis when assuming different inheritance models (I² < 50% or P > 0.10 for the entire sample and after stratification by ethnicity). Meta-analysis results revealed significant associations between the K121Q polymorphism and risk of DKD in Asians and Europeans when assuming the different inheritance models analyzed. The most powerful association was observed for the additive model (OR = 1.74, 95% CI 1.27-2.38 for the total sample). In conclusion, the present meta-analysis detected a significant association between the ENPP1K121Q polymorphism and increased susceptibility of DKD in European and Asian populations. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2016-11-19T02:16:42Z |
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Estrangeiro info:eu-repo/semantics/article |
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format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/149736 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000997336 |
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1932-6203 000997336 |
url |
http://hdl.handle.net/10183/149736 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PLoS ONE. San Francisco. Vol. 10, no. 3 (Mar. 2015), e0118416, 15 p. |
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openAccess |
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