Characterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysis

Detalhes bibliográficos
Autor(a) principal: Mendez, Andreas Sebastian Loureiro
Data de Publicação: 2011
Outros Autores: Mantovani, Luciano, Barbosa, Fábio de Souza, Sayago, Carla T.M., Garcia, Cassia Virginia, Paula, Fávero Reisdorfer, Silva, Fabiana Ernestina Barcellos da, Denardin, Elton Luis Gasparotto, Schapoval, Elfrides Eva Scherman
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/72934
Resumo: Doripenem was characterized through physicochemical and spectroscopic techniques, as well as thermal analysis. TLC (Rf = 0.62) and HPLC (rt = 7.4 min) were found to be adequate to identify the drug. UV and infrared spectra showed similar profile between doripenem bulk and standard. The 1H and 13C NMR analysis revealed chemical shifts that allowed identifying the drug. Thermal analysis demonstrated three steps with mass loss, at 128, 178 and 276 oC. The work was successfully applied to qualitative analysis of doripenem, showing the reported methods can be used for physicochemical characterization of doripenem.
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spelling Mendez, Andreas Sebastian LoureiroMantovani, LucianoBarbosa, Fábio de SouzaSayago, Carla T.M.Garcia, Cassia VirginiaPaula, Fávero ReisdorferSilva, Fabiana Ernestina Barcellos daDenardin, Elton Luis GasparottoSchapoval, Elfrides Eva Scherman2013-07-02T01:43:46Z20110100-4042http://hdl.handle.net/10183/72934000792844Doripenem was characterized through physicochemical and spectroscopic techniques, as well as thermal analysis. TLC (Rf = 0.62) and HPLC (rt = 7.4 min) were found to be adequate to identify the drug. UV and infrared spectra showed similar profile between doripenem bulk and standard. The 1H and 13C NMR analysis revealed chemical shifts that allowed identifying the drug. Thermal analysis demonstrated three steps with mass loss, at 128, 178 and 276 oC. The work was successfully applied to qualitative analysis of doripenem, showing the reported methods can be used for physicochemical characterization of doripenem.application/pdfengQuímica nova. São Paulo. Vol. 34, n. 9 (2011), p. 1634-1638DoripenemAntibióticosMétodos físico-químicos de análiseQualitative analysisPhysicochemical methodsCharacterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000792844.pdf000792844.pdfTexto completo (inglês)application/pdf596651http://www.lume.ufrgs.br/bitstream/10183/72934/1/000792844.pdfc4b2d48272859718b80e62a0bb53a5c0MD51TEXT000792844.pdf.txt000792844.pdf.txtExtracted Texttext/plain26329http://www.lume.ufrgs.br/bitstream/10183/72934/2/000792844.pdf.txt0dbf1f50b7e12f05d3b7e579fbc9c5d0MD52THUMBNAIL000792844.pdf.jpg000792844.pdf.jpgGenerated Thumbnailimage/jpeg1920http://www.lume.ufrgs.br/bitstream/10183/72934/3/000792844.pdf.jpgb7cbc447dfea131d0e11cca4bb5e5dabMD5310183/729342018-10-15 08:05:44.264oai:www.lume.ufrgs.br:10183/72934Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-15T11:05:44Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Characterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysis
title Characterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysis
spellingShingle Characterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysis
Mendez, Andreas Sebastian Loureiro
Doripenem
Antibióticos
Métodos físico-químicos de análise
Qualitative analysis
Physicochemical methods
title_short Characterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysis
title_full Characterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysis
title_fullStr Characterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysis
title_full_unstemmed Characterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysis
title_sort Characterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysis
author Mendez, Andreas Sebastian Loureiro
author_facet Mendez, Andreas Sebastian Loureiro
Mantovani, Luciano
Barbosa, Fábio de Souza
Sayago, Carla T.M.
Garcia, Cassia Virginia
Paula, Fávero Reisdorfer
Silva, Fabiana Ernestina Barcellos da
Denardin, Elton Luis Gasparotto
Schapoval, Elfrides Eva Scherman
author_role author
author2 Mantovani, Luciano
Barbosa, Fábio de Souza
Sayago, Carla T.M.
Garcia, Cassia Virginia
Paula, Fávero Reisdorfer
Silva, Fabiana Ernestina Barcellos da
Denardin, Elton Luis Gasparotto
Schapoval, Elfrides Eva Scherman
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendez, Andreas Sebastian Loureiro
Mantovani, Luciano
Barbosa, Fábio de Souza
Sayago, Carla T.M.
Garcia, Cassia Virginia
Paula, Fávero Reisdorfer
Silva, Fabiana Ernestina Barcellos da
Denardin, Elton Luis Gasparotto
Schapoval, Elfrides Eva Scherman
dc.subject.por.fl_str_mv Doripenem
Antibióticos
Métodos físico-químicos de análise
topic Doripenem
Antibióticos
Métodos físico-químicos de análise
Qualitative analysis
Physicochemical methods
dc.subject.eng.fl_str_mv Qualitative analysis
Physicochemical methods
description Doripenem was characterized through physicochemical and spectroscopic techniques, as well as thermal analysis. TLC (Rf = 0.62) and HPLC (rt = 7.4 min) were found to be adequate to identify the drug. UV and infrared spectra showed similar profile between doripenem bulk and standard. The 1H and 13C NMR analysis revealed chemical shifts that allowed identifying the drug. Thermal analysis demonstrated three steps with mass loss, at 128, 178 and 276 oC. The work was successfully applied to qualitative analysis of doripenem, showing the reported methods can be used for physicochemical characterization of doripenem.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2013-07-02T01:43:46Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/72934
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
dc.identifier.nrb.pt_BR.fl_str_mv 000792844
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo. Vol. 34, n. 9 (2011), p. 1634-1638
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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reponame_str Repositório Institucional da UFRGS
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