Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2000 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21155 |
Resumo: | Several investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training is an efficient non-pharmacological treatment for cardiac and metabolic diseases. The aim of the present study was to investigate the effects of exercise training on hemodynamic and autonomic diabetic dysfunction. After 1 week of diabetes induction (streptozotocin, 50 mg/kg, iv), male Wistar rats (222 ± 5 g, N = 18) were submitted to exercise training for 10 weeks on a treadmill. Arterial pressure signals were obtained and processed with a data acquisition system. Autonomic function and intrinsic heart rate were studied by injecting methylatropine and propranolol. Left ventricular function was assessed in hearts perfused in vitro by the Langendorff technique. Diabetes (D) bradycardia and hypotension (D: 279 ± 9 bpm and 91 ± 4 mmHg vs 315 ± 11 bpm and 111 ± 4 mmHg in controls, C) were attenuated by training (TD: 305 ± 7 bpm and 100 ± 4 mmHg). Vagal tonus was decreased in the diabetic groups and sympathetic tonus was similar in all animals. Intrinsic heart rate was lower in D (284 ± 11 bpm) compared to C and TD (390 ± 8 and 342 ± 14 bpm, respectively). Peak systolic pressure developed at different pressures was similar for all groups, but +dP/dt max was decreased and -dP/dt max was increased in D. In conclusion, exercise training reversed hypotension and bradycardia and improved myocardial function in diabetic rats. These changes represent an adaptive response to the demands of training, supporting a positive role of physical activity in the management of diabetes. |
id |
UFRGS-2_5b729b30f2eed4ed1a11f423df7260a9 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/21155 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
D'Avila, Katia de Angelis LoboOliveira, Álvaro Reischak deDall'Ago, PedroPeixoto, Lívia Rodrigues AraújoGadonski, GiovaniLacchini, SilviaPiedras, Tania Regina Gattelli FernandesIrigoyen, Maria Claudia Costa2010-04-24T04:15:31Z20000100-879Xhttp://hdl.handle.net/10183/21155000295587Several investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training is an efficient non-pharmacological treatment for cardiac and metabolic diseases. The aim of the present study was to investigate the effects of exercise training on hemodynamic and autonomic diabetic dysfunction. After 1 week of diabetes induction (streptozotocin, 50 mg/kg, iv), male Wistar rats (222 ± 5 g, N = 18) were submitted to exercise training for 10 weeks on a treadmill. Arterial pressure signals were obtained and processed with a data acquisition system. Autonomic function and intrinsic heart rate were studied by injecting methylatropine and propranolol. Left ventricular function was assessed in hearts perfused in vitro by the Langendorff technique. Diabetes (D) bradycardia and hypotension (D: 279 ± 9 bpm and 91 ± 4 mmHg vs 315 ± 11 bpm and 111 ± 4 mmHg in controls, C) were attenuated by training (TD: 305 ± 7 bpm and 100 ± 4 mmHg). Vagal tonus was decreased in the diabetic groups and sympathetic tonus was similar in all animals. Intrinsic heart rate was lower in D (284 ± 11 bpm) compared to C and TD (390 ± 8 and 342 ± 14 bpm, respectively). Peak systolic pressure developed at different pressures was similar for all groups, but +dP/dt max was decreased and -dP/dt max was increased in D. In conclusion, exercise training reversed hypotension and bradycardia and improved myocardial function in diabetic rats. These changes represent an adaptive response to the demands of training, supporting a positive role of physical activity in the management of diabetes.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 6 (June 2000), p. 635-641Diabete : Frequencia cardiaca : Pressao arterial : RatosExercício físicoFisiologiaExperimental diabetesExercise trainingArterial pressureAutonomic controlMyocardial contractilityEffects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic ratsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000295587.pdf000295587.pdfTexto completo (inglês)application/pdf152563http://www.lume.ufrgs.br/bitstream/10183/21155/1/000295587.pdfa149258a3fd7d6513b0af09a899fc1d6MD51TEXT000295587.pdf.txt000295587.pdf.txtExtracted Texttext/plain26329http://www.lume.ufrgs.br/bitstream/10183/21155/2/000295587.pdf.txt4f1e8d49fb67cce5cb7bd19b4084a327MD52THUMBNAIL000295587.pdf.jpg000295587.pdf.jpgGenerated Thumbnailimage/jpeg1688http://www.lume.ufrgs.br/bitstream/10183/21155/3/000295587.pdf.jpg035efc43a1aafdddb1f377e31b931de2MD5310183/211552022-11-18 05:55:29.944556oai:www.lume.ufrgs.br:10183/21155Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-11-18T07:55:29Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats |
title |
Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats |
spellingShingle |
Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats D'Avila, Katia de Angelis Lobo Diabete : Frequencia cardiaca : Pressao arterial : Ratos Exercício físico Fisiologia Experimental diabetes Exercise training Arterial pressure Autonomic control Myocardial contractility |
title_short |
Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats |
title_full |
Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats |
title_fullStr |
Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats |
title_full_unstemmed |
Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats |
title_sort |
Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats |
author |
D'Avila, Katia de Angelis Lobo |
author_facet |
D'Avila, Katia de Angelis Lobo Oliveira, Álvaro Reischak de Dall'Ago, Pedro Peixoto, Lívia Rodrigues Araújo Gadonski, Giovani Lacchini, Silvia Piedras, Tania Regina Gattelli Fernandes Irigoyen, Maria Claudia Costa |
author_role |
author |
author2 |
Oliveira, Álvaro Reischak de Dall'Ago, Pedro Peixoto, Lívia Rodrigues Araújo Gadonski, Giovani Lacchini, Silvia Piedras, Tania Regina Gattelli Fernandes Irigoyen, Maria Claudia Costa |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
D'Avila, Katia de Angelis Lobo Oliveira, Álvaro Reischak de Dall'Ago, Pedro Peixoto, Lívia Rodrigues Araújo Gadonski, Giovani Lacchini, Silvia Piedras, Tania Regina Gattelli Fernandes Irigoyen, Maria Claudia Costa |
dc.subject.por.fl_str_mv |
Diabete : Frequencia cardiaca : Pressao arterial : Ratos Exercício físico Fisiologia |
topic |
Diabete : Frequencia cardiaca : Pressao arterial : Ratos Exercício físico Fisiologia Experimental diabetes Exercise training Arterial pressure Autonomic control Myocardial contractility |
dc.subject.eng.fl_str_mv |
Experimental diabetes Exercise training Arterial pressure Autonomic control Myocardial contractility |
description |
Several investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training is an efficient non-pharmacological treatment for cardiac and metabolic diseases. The aim of the present study was to investigate the effects of exercise training on hemodynamic and autonomic diabetic dysfunction. After 1 week of diabetes induction (streptozotocin, 50 mg/kg, iv), male Wistar rats (222 ± 5 g, N = 18) were submitted to exercise training for 10 weeks on a treadmill. Arterial pressure signals were obtained and processed with a data acquisition system. Autonomic function and intrinsic heart rate were studied by injecting methylatropine and propranolol. Left ventricular function was assessed in hearts perfused in vitro by the Langendorff technique. Diabetes (D) bradycardia and hypotension (D: 279 ± 9 bpm and 91 ± 4 mmHg vs 315 ± 11 bpm and 111 ± 4 mmHg in controls, C) were attenuated by training (TD: 305 ± 7 bpm and 100 ± 4 mmHg). Vagal tonus was decreased in the diabetic groups and sympathetic tonus was similar in all animals. Intrinsic heart rate was lower in D (284 ± 11 bpm) compared to C and TD (390 ± 8 and 342 ± 14 bpm, respectively). Peak systolic pressure developed at different pressures was similar for all groups, but +dP/dt max was decreased and -dP/dt max was increased in D. In conclusion, exercise training reversed hypotension and bradycardia and improved myocardial function in diabetic rats. These changes represent an adaptive response to the demands of training, supporting a positive role of physical activity in the management of diabetes. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:31Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/21155 |
dc.identifier.issn.pt_BR.fl_str_mv |
0100-879X |
dc.identifier.nrb.pt_BR.fl_str_mv |
000295587 |
identifier_str_mv |
0100-879X 000295587 |
url |
http://hdl.handle.net/10183/21155 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 6 (June 2000), p. 635-641 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/21155/1/000295587.pdf http://www.lume.ufrgs.br/bitstream/10183/21155/2/000295587.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/21155/3/000295587.pdf.jpg |
bitstream.checksum.fl_str_mv |
a149258a3fd7d6513b0af09a899fc1d6 4f1e8d49fb67cce5cb7bd19b4084a327 035efc43a1aafdddb1f377e31b931de2 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1798487089113726976 |