Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

Detalhes bibliográficos
Autor(a) principal: Li,Ting
Data de Publicação: 2021
Outros Autores: Bau, Claiton Henrique Dotto, Grevet, Eugenio Horácio, Picon, Felipe Almeida, Franke, Barbara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/252570
Resumo: Background: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. Methods: Using the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. Results: Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case-control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. Conclusions: Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups.
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spelling Li,TingBau, Claiton Henrique DottoGrevet, Eugenio HorácioPicon, Felipe AlmeidaFranke, Barbara2022-12-09T04:58:45Z20210021-9630http://hdl.handle.net/10183/252570001154609Background: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. Methods: Using the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. Results: Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case-control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. Conclusions: Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups.application/pdfengJournal of child psychology and psychiatry. Oxford. Vol. 62, n. 9 (2021), p. 1140-1149Transtorno do déficit de atenção com hiperatividadeEncéfaloDiagnóstico por imagemImageamento por ressonância magnéticaTálamoADHDComunity detectionEffect sizesNeuroanatomic heterogeneitySubcortical volumeCharacterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001154609.pdf.txt001154609.pdf.txtExtracted Texttext/plain56416http://www.lume.ufrgs.br/bitstream/10183/252570/2/001154609.pdf.txtd978c260c032c82e471978dde130921eMD52ORIGINAL001154609.pdfTexto completo (inglês)application/pdf484356http://www.lume.ufrgs.br/bitstream/10183/252570/1/001154609.pdf0b764eb4874b0d7a5311573c7fb79806MD5110183/2525702023-05-10 03:27:57.211867oai:www.lume.ufrgs.br:10183/252570Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-05-10T06:27:57Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
title Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
spellingShingle Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
Li,Ting
Transtorno do déficit de atenção com hiperatividade
Encéfalo
Diagnóstico por imagem
Imageamento por ressonância magnética
Tálamo
ADHD
Comunity detection
Effect sizes
Neuroanatomic heterogeneity
Subcortical volume
title_short Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
title_full Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
title_fullStr Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
title_full_unstemmed Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
title_sort Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
author Li,Ting
author_facet Li,Ting
Bau, Claiton Henrique Dotto
Grevet, Eugenio Horácio
Picon, Felipe Almeida
Franke, Barbara
author_role author
author2 Bau, Claiton Henrique Dotto
Grevet, Eugenio Horácio
Picon, Felipe Almeida
Franke, Barbara
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Li,Ting
Bau, Claiton Henrique Dotto
Grevet, Eugenio Horácio
Picon, Felipe Almeida
Franke, Barbara
dc.subject.por.fl_str_mv Transtorno do déficit de atenção com hiperatividade
Encéfalo
Diagnóstico por imagem
Imageamento por ressonância magnética
Tálamo
topic Transtorno do déficit de atenção com hiperatividade
Encéfalo
Diagnóstico por imagem
Imageamento por ressonância magnética
Tálamo
ADHD
Comunity detection
Effect sizes
Neuroanatomic heterogeneity
Subcortical volume
dc.subject.eng.fl_str_mv ADHD
Comunity detection
Effect sizes
Neuroanatomic heterogeneity
Subcortical volume
description Background: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. Methods: Using the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. Results: Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case-control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. Conclusions: Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-12-09T04:58:45Z
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dc.relation.ispartof.pt_BR.fl_str_mv Journal of child psychology and psychiatry. Oxford. Vol. 62, n. 9 (2021), p. 1140-1149
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