Association between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/183902 |
Resumo: | Background - Discovery and incorporation of biomarker panels to cancer studies enabled the understanding of genetic variation and its interference in carcinogenesis at molecular level. The potential association between single nucleotide polymorphism (SNP) 309 and increased development of tumors, such as hepatocellular carcinoma, has been subject to several studies. This is the first study on this association conducted in Brazil. Methods - 62 cases of cirrhotic patients with hepatocellular carcinoma surgically treated by partial hepatectomy (HPT) or by liver transplantation (LTX) from 2000 to 2009 at Santa Casa Hospital Complex, in the city of Porto Alegre, were retrospectively analyzed. Tumor samples from surgical specimen were collected and prepared for study in paraffin blocks. Results - Overall survival was 26.7 months in the HPT group and 62.4 months in the LTX group (P<0.01). Overall tumor recurrence was 66.7% in the HPT group (10/15) and 17% in the LTX group (8/47) (X²=13.602, P<0.01). Alpha-fetoprotein levels >200ng/mL, microvascular invasion and histological grade were associated with tumor recurrence (P<0.01). Recurrence rates in each surgical group and analysis of factors associated with tumor recurrence, when stratified for each genotypic pattern, were both not statistically significant. Conclusion - G/G genotype was not associated with tumor recurrence after surgical treatment and it did not show any correlation with other prognostic factors. |
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Teixeira, Uirá FernandesIzaguirre, Andréa Gomes CoelhoMachry, Mayara ChristCerski, Carlos Thadeu SchmidtBrandao, Ajacio Bandeira de MelloFontes, Paulo Roberto Ott2018-10-23T02:41:29Z20150004-2803http://hdl.handle.net/10183/183902001070444Background - Discovery and incorporation of biomarker panels to cancer studies enabled the understanding of genetic variation and its interference in carcinogenesis at molecular level. The potential association between single nucleotide polymorphism (SNP) 309 and increased development of tumors, such as hepatocellular carcinoma, has been subject to several studies. This is the first study on this association conducted in Brazil. Methods - 62 cases of cirrhotic patients with hepatocellular carcinoma surgically treated by partial hepatectomy (HPT) or by liver transplantation (LTX) from 2000 to 2009 at Santa Casa Hospital Complex, in the city of Porto Alegre, were retrospectively analyzed. Tumor samples from surgical specimen were collected and prepared for study in paraffin blocks. Results - Overall survival was 26.7 months in the HPT group and 62.4 months in the LTX group (P<0.01). Overall tumor recurrence was 66.7% in the HPT group (10/15) and 17% in the LTX group (8/47) (X²=13.602, P<0.01). Alpha-fetoprotein levels >200ng/mL, microvascular invasion and histological grade were associated with tumor recurrence (P<0.01). Recurrence rates in each surgical group and analysis of factors associated with tumor recurrence, when stratified for each genotypic pattern, were both not statistically significant. Conclusion - G/G genotype was not associated with tumor recurrence after surgical treatment and it did not show any correlation with other prognostic factors.application/pdfengArquivos de gastroenterologia. São Paulo. Vol. 52, n. 4 (out./nov. 2015), p. 325-330Carcinoma hepatocelularPredisposição genética para doençaNeoplasias hepáticasIdoso de 80 anos ou maisIntervalo livre de doençaProto-oncogene proteins C-MDM2Single-stranded conformational polymorphismHepatocellular carcinomaBiological tumor markersAssociation between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatmentAssociação entre o polimorfismo T309G – murine double minute 2 e a recorrência do carcinoma hepatocelular após o tratamento cirúrgico info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001070444.pdfTexto completo (inglês)application/pdf131891http://www.lume.ufrgs.br/bitstream/10183/183902/1/001070444.pdfad812981affbf772cd41d990ffe5ae12MD51TEXT001070444.pdf.txt001070444.pdf.txtExtracted Texttext/plain28521http://www.lume.ufrgs.br/bitstream/10183/183902/2/001070444.pdf.txt63c86d3886dd0612b1185f4e801dc79eMD52THUMBNAIL001070444.pdf.jpg001070444.pdf.jpgGenerated Thumbnailimage/jpeg2007http://www.lume.ufrgs.br/bitstream/10183/183902/3/001070444.pdf.jpg4e08c13e159e1bddbd8f37a13317ad45MD5310183/1839022019-10-20 03:52:54.784548oai:www.lume.ufrgs.br:10183/183902Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2019-10-20T06:52:54Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Association between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment |
dc.title.alternative.pt.fl_str_mv |
Associação entre o polimorfismo T309G – murine double minute 2 e a recorrência do carcinoma hepatocelular após o tratamento cirúrgico |
title |
Association between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment |
spellingShingle |
Association between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment Teixeira, Uirá Fernandes Carcinoma hepatocelular Predisposição genética para doença Neoplasias hepáticas Idoso de 80 anos ou mais Intervalo livre de doença Proto-oncogene proteins C-MDM2 Single-stranded conformational polymorphism Hepatocellular carcinoma Biological tumor markers |
title_short |
Association between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment |
title_full |
Association between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment |
title_fullStr |
Association between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment |
title_full_unstemmed |
Association between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment |
title_sort |
Association between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment |
author |
Teixeira, Uirá Fernandes |
author_facet |
Teixeira, Uirá Fernandes Izaguirre, Andréa Gomes Coelho Machry, Mayara Christ Cerski, Carlos Thadeu Schmidt Brandao, Ajacio Bandeira de Mello Fontes, Paulo Roberto Ott |
author_role |
author |
author2 |
Izaguirre, Andréa Gomes Coelho Machry, Mayara Christ Cerski, Carlos Thadeu Schmidt Brandao, Ajacio Bandeira de Mello Fontes, Paulo Roberto Ott |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira, Uirá Fernandes Izaguirre, Andréa Gomes Coelho Machry, Mayara Christ Cerski, Carlos Thadeu Schmidt Brandao, Ajacio Bandeira de Mello Fontes, Paulo Roberto Ott |
dc.subject.por.fl_str_mv |
Carcinoma hepatocelular Predisposição genética para doença Neoplasias hepáticas Idoso de 80 anos ou mais Intervalo livre de doença |
topic |
Carcinoma hepatocelular Predisposição genética para doença Neoplasias hepáticas Idoso de 80 anos ou mais Intervalo livre de doença Proto-oncogene proteins C-MDM2 Single-stranded conformational polymorphism Hepatocellular carcinoma Biological tumor markers |
dc.subject.eng.fl_str_mv |
Proto-oncogene proteins C-MDM2 Single-stranded conformational polymorphism Hepatocellular carcinoma Biological tumor markers |
description |
Background - Discovery and incorporation of biomarker panels to cancer studies enabled the understanding of genetic variation and its interference in carcinogenesis at molecular level. The potential association between single nucleotide polymorphism (SNP) 309 and increased development of tumors, such as hepatocellular carcinoma, has been subject to several studies. This is the first study on this association conducted in Brazil. Methods - 62 cases of cirrhotic patients with hepatocellular carcinoma surgically treated by partial hepatectomy (HPT) or by liver transplantation (LTX) from 2000 to 2009 at Santa Casa Hospital Complex, in the city of Porto Alegre, were retrospectively analyzed. Tumor samples from surgical specimen were collected and prepared for study in paraffin blocks. Results - Overall survival was 26.7 months in the HPT group and 62.4 months in the LTX group (P<0.01). Overall tumor recurrence was 66.7% in the HPT group (10/15) and 17% in the LTX group (8/47) (X²=13.602, P<0.01). Alpha-fetoprotein levels >200ng/mL, microvascular invasion and histological grade were associated with tumor recurrence (P<0.01). Recurrence rates in each surgical group and analysis of factors associated with tumor recurrence, when stratified for each genotypic pattern, were both not statistically significant. Conclusion - G/G genotype was not associated with tumor recurrence after surgical treatment and it did not show any correlation with other prognostic factors. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
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2018-10-23T02:41:29Z |
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http://hdl.handle.net/10183/183902 |
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0004-2803 |
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001070444 |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Arquivos de gastroenterologia. São Paulo. Vol. 52, n. 4 (out./nov. 2015), p. 325-330 |
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