Behavioral manifestations in rodent models of autism spectrum disorder : protocol for a systematic review and network meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/249001 |
Resumo: | Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with severe social communication, interaction, and sensory processing impairments. Efforts to understand its etiology and pathophysiology are crucial for improving treatment and prevention measures. Preclinical models of ASD are essential for investigating the biological mechanisms and should present translatability potential. We aim to evaluate the consistency of the most commonly used rodent models of ASD in displaying autistic-like behavior through a systematic review and meta-analysis. Methods: This review will focus on the most frequently used autism models, surveying studies of six genetic (Ube3a, Pten, Nlgn3, Shank3, Mecp2, and Fmr1), three chemically induced (valproic acid (VPA), lipopolysaccharide (LPS), and polyinosinic:polycytidylic acid (poly(I:C))), and one inbred model (BTBR T+ Itpr3tf/J mouse strain). Two independent reviewers will screen the records. Data extraction of behavioral outcomes and risk of bias evaluation will be performed. We will conduct a meta-analysis whenever at least five studies investigate the same model and behavioral outcome. We will also explore the heterogeneity and publication bias. Network meta-analyses are planned to compare different models. Discussion: By shortening the gap between animal behavior and human endophenotypes or specific clinical symptoms, we expect to help researchers on which rodent models are adequate for research of specific behavioral manifestations of autism, which potentially require a combination of them depending on the research interest. |
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Panzenhagen, Alana Eduarda de CastroCavalcanti, AmandaStein, Dirson JoãoCastro, Ligia Lins deVasconcelos, Mailton França deAbreu, Mariana BoechatAlmeida, Roberto Farina deBertoglio, Leandro JoséHerrmann, Ana Paula2022-09-16T05:00:30Z20222046-4053http://hdl.handle.net/10183/249001001148533Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with severe social communication, interaction, and sensory processing impairments. Efforts to understand its etiology and pathophysiology are crucial for improving treatment and prevention measures. Preclinical models of ASD are essential for investigating the biological mechanisms and should present translatability potential. We aim to evaluate the consistency of the most commonly used rodent models of ASD in displaying autistic-like behavior through a systematic review and meta-analysis. Methods: This review will focus on the most frequently used autism models, surveying studies of six genetic (Ube3a, Pten, Nlgn3, Shank3, Mecp2, and Fmr1), three chemically induced (valproic acid (VPA), lipopolysaccharide (LPS), and polyinosinic:polycytidylic acid (poly(I:C))), and one inbred model (BTBR T+ Itpr3tf/J mouse strain). Two independent reviewers will screen the records. Data extraction of behavioral outcomes and risk of bias evaluation will be performed. We will conduct a meta-analysis whenever at least five studies investigate the same model and behavioral outcome. We will also explore the heterogeneity and publication bias. Network meta-analyses are planned to compare different models. Discussion: By shortening the gap between animal behavior and human endophenotypes or specific clinical symptoms, we expect to help researchers on which rodent models are adequate for research of specific behavioral manifestations of autism, which potentially require a combination of them depending on the research interest.application/pdfengSystematic reviews. London. Vol. 11 (2022), 150, 7 p.Transtorno do espectro autistaModelos animais de doençasRevisão sistemáticaAnimal modelAutismAutism spectrum disorderRodent modelSystematic reviewNetwork meta-analysisProtocolBehavioral manifestations in rodent models of autism spectrum disorder : protocol for a systematic review and network meta-analysisEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001148533.pdf.txt001148533.pdf.txtExtracted Texttext/plain35861http://www.lume.ufrgs.br/bitstream/10183/249001/2/001148533.pdf.txt9a25d5b60c00847bc00930292f501041MD52ORIGINAL001148533.pdfTexto completo (inglês)application/pdf891383http://www.lume.ufrgs.br/bitstream/10183/249001/1/001148533.pdfb6af79b76cd8a61b43d6e2d8486fda70MD5110183/2490012022-09-17 05:09:35.944326oai:www.lume.ufrgs.br:10183/249001Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-09-17T08:09:35Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Behavioral manifestations in rodent models of autism spectrum disorder : protocol for a systematic review and network meta-analysis |
title |
Behavioral manifestations in rodent models of autism spectrum disorder : protocol for a systematic review and network meta-analysis |
spellingShingle |
Behavioral manifestations in rodent models of autism spectrum disorder : protocol for a systematic review and network meta-analysis Panzenhagen, Alana Eduarda de Castro Transtorno do espectro autista Modelos animais de doenças Revisão sistemática Animal model Autism Autism spectrum disorder Rodent model Systematic review Network meta-analysis Protocol |
title_short |
Behavioral manifestations in rodent models of autism spectrum disorder : protocol for a systematic review and network meta-analysis |
title_full |
Behavioral manifestations in rodent models of autism spectrum disorder : protocol for a systematic review and network meta-analysis |
title_fullStr |
Behavioral manifestations in rodent models of autism spectrum disorder : protocol for a systematic review and network meta-analysis |
title_full_unstemmed |
Behavioral manifestations in rodent models of autism spectrum disorder : protocol for a systematic review and network meta-analysis |
title_sort |
Behavioral manifestations in rodent models of autism spectrum disorder : protocol for a systematic review and network meta-analysis |
author |
Panzenhagen, Alana Eduarda de Castro |
author_facet |
Panzenhagen, Alana Eduarda de Castro Cavalcanti, Amanda Stein, Dirson João Castro, Ligia Lins de Vasconcelos, Mailton França de Abreu, Mariana Boechat Almeida, Roberto Farina de Bertoglio, Leandro José Herrmann, Ana Paula |
author_role |
author |
author2 |
Cavalcanti, Amanda Stein, Dirson João Castro, Ligia Lins de Vasconcelos, Mailton França de Abreu, Mariana Boechat Almeida, Roberto Farina de Bertoglio, Leandro José Herrmann, Ana Paula |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Panzenhagen, Alana Eduarda de Castro Cavalcanti, Amanda Stein, Dirson João Castro, Ligia Lins de Vasconcelos, Mailton França de Abreu, Mariana Boechat Almeida, Roberto Farina de Bertoglio, Leandro José Herrmann, Ana Paula |
dc.subject.por.fl_str_mv |
Transtorno do espectro autista Modelos animais de doenças Revisão sistemática |
topic |
Transtorno do espectro autista Modelos animais de doenças Revisão sistemática Animal model Autism Autism spectrum disorder Rodent model Systematic review Network meta-analysis Protocol |
dc.subject.eng.fl_str_mv |
Animal model Autism Autism spectrum disorder Rodent model Systematic review Network meta-analysis Protocol |
description |
Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with severe social communication, interaction, and sensory processing impairments. Efforts to understand its etiology and pathophysiology are crucial for improving treatment and prevention measures. Preclinical models of ASD are essential for investigating the biological mechanisms and should present translatability potential. We aim to evaluate the consistency of the most commonly used rodent models of ASD in displaying autistic-like behavior through a systematic review and meta-analysis. Methods: This review will focus on the most frequently used autism models, surveying studies of six genetic (Ube3a, Pten, Nlgn3, Shank3, Mecp2, and Fmr1), three chemically induced (valproic acid (VPA), lipopolysaccharide (LPS), and polyinosinic:polycytidylic acid (poly(I:C))), and one inbred model (BTBR T+ Itpr3tf/J mouse strain). Two independent reviewers will screen the records. Data extraction of behavioral outcomes and risk of bias evaluation will be performed. We will conduct a meta-analysis whenever at least five studies investigate the same model and behavioral outcome. We will also explore the heterogeneity and publication bias. Network meta-analyses are planned to compare different models. Discussion: By shortening the gap between animal behavior and human endophenotypes or specific clinical symptoms, we expect to help researchers on which rodent models are adequate for research of specific behavioral manifestations of autism, which potentially require a combination of them depending on the research interest. |
publishDate |
2022 |
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2022 |
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http://hdl.handle.net/10183/249001 |
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2046-4053 |
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001148533 |
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eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Systematic reviews. London. Vol. 11 (2022), 150, 7 p. |
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openAccess |
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