Life course socioeconomic position and c-reactive protein : mediating role of health-risk behaviors and metabolic alterations. The brazilian longitudinal study of adult health (ELSA-Brasil)
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/129914 |
Resumo: | Background: Chronic inflammation has been postulated to be one mediating mechanism explaining the association between low socioeconomic position (SEP) and cardiovascular disease (CVD). We sought to examine the association between life course SEP and C-reactive protein (CRP) levels in adulthood, and to evaluate the extent to which health-risk behaviors and metabolic alterations mediate this association. Additionally, we explored the possible modifying influence of gender. Methods and Findings: Our analytical sample comprised 13,371 participants from ELSA-Brasil baseline, a multicenter prospective cohort study of civil servants. SEP during childhood, young adulthood, and adulthood were considered. The potential mediators between life course SEP and CRP included clusters of health-risk behaviors (smoking, low leisure time physical activity, excessive alcohol consumption), and metabolic alterations (obesity, hypertension, low HDL, hypertriglyceridemia, and diabetes). Linear regression models were performed and structural equation modeling was used to evaluate mediation Although lower childhood SEP was associated with higher levels of CRP in adult life, this association was not independent of adulthood SEP. However, CRP increased linearly with increasing number of unfavorable social circumstances during the life course (p trend ,0.001). The metabolic alterations were the most important mediator between cumulative SEP and CRP. This mediation path accounted for 49.5% of the total effect of cumulative SEP on CRP among women, but only 20.2% among men. In consequence, the portion of the total effect of cumulative SEP on CRP that was mediated by risk behaviors and metabolic alterations was higher among women (55.4%) than among men (36.8%). Conclusions: Cumulative SEP across life span was associated with elevated systemic inflammation in adulthood. Although health-risk behaviors and metabolic alterations were important mediators of this association, a sizable fraction of this association was not mediated by these factors, suggesting that other pathways might play a role, especially among men. |
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Camelo, Lidyane do ValleGiatti, LuanaNeves, Jorge Alexandre BarbosaLotufo, Paulo AndradeBenseñor, Isabela Judith MartinsChor, DoraGriep, Rosane HarterFonseca, Maria de Jesus Mendes daVidigal, Pedro GuatimosimKawachi, IchiroSchmidt, Maria InêsBarreto, Sandhi Maria2015-11-19T02:39:44Z20141932-6203http://hdl.handle.net/10183/129914000963625Background: Chronic inflammation has been postulated to be one mediating mechanism explaining the association between low socioeconomic position (SEP) and cardiovascular disease (CVD). We sought to examine the association between life course SEP and C-reactive protein (CRP) levels in adulthood, and to evaluate the extent to which health-risk behaviors and metabolic alterations mediate this association. Additionally, we explored the possible modifying influence of gender. Methods and Findings: Our analytical sample comprised 13,371 participants from ELSA-Brasil baseline, a multicenter prospective cohort study of civil servants. SEP during childhood, young adulthood, and adulthood were considered. The potential mediators between life course SEP and CRP included clusters of health-risk behaviors (smoking, low leisure time physical activity, excessive alcohol consumption), and metabolic alterations (obesity, hypertension, low HDL, hypertriglyceridemia, and diabetes). Linear regression models were performed and structural equation modeling was used to evaluate mediation Although lower childhood SEP was associated with higher levels of CRP in adult life, this association was not independent of adulthood SEP. However, CRP increased linearly with increasing number of unfavorable social circumstances during the life course (p trend ,0.001). The metabolic alterations were the most important mediator between cumulative SEP and CRP. This mediation path accounted for 49.5% of the total effect of cumulative SEP on CRP among women, but only 20.2% among men. In consequence, the portion of the total effect of cumulative SEP on CRP that was mediated by risk behaviors and metabolic alterations was higher among women (55.4%) than among men (36.8%). Conclusions: Cumulative SEP across life span was associated with elevated systemic inflammation in adulthood. Although health-risk behaviors and metabolic alterations were important mediators of this association, a sizable fraction of this association was not mediated by these factors, suggesting that other pathways might play a role, especially among men.application/pdfengPLoS ONE. San Francisco. Vol. 9, no. 10 (Oct. 2014), e108426, 12 p.InflamaçãoDoenças cardiovascularesProteina C-reativaLife course socioeconomic position and c-reactive protein : mediating role of health-risk behaviors and metabolic alterations. The brazilian longitudinal study of adult health (ELSA-Brasil)Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000963625.pdf000963625.pdfTexto completo (inglês)application/pdf580795http://www.lume.ufrgs.br/bitstream/10183/129914/1/000963625.pdf9d2450004088fe29303392c4a3ec97e7MD51TEXT000963625.pdf.txt000963625.pdf.txtExtracted Texttext/plain65485http://www.lume.ufrgs.br/bitstream/10183/129914/2/000963625.pdf.txtbe6dbd0cf6e72748f0ee099ff9d79a55MD52THUMBNAIL000963625.pdf.jpg000963625.pdf.jpgGenerated Thumbnailimage/jpeg2223http://www.lume.ufrgs.br/bitstream/10183/129914/3/000963625.pdf.jpg942696b9c2c454dea1b354b4f7767c8cMD5310183/1299142021-09-18 04:47:52.384578oai:www.lume.ufrgs.br:10183/129914Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-09-18T07:47:52Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Life course socioeconomic position and c-reactive protein : mediating role of health-risk behaviors and metabolic alterations. The brazilian longitudinal study of adult health (ELSA-Brasil) |
title |
Life course socioeconomic position and c-reactive protein : mediating role of health-risk behaviors and metabolic alterations. The brazilian longitudinal study of adult health (ELSA-Brasil) |
spellingShingle |
Life course socioeconomic position and c-reactive protein : mediating role of health-risk behaviors and metabolic alterations. The brazilian longitudinal study of adult health (ELSA-Brasil) Camelo, Lidyane do Valle Inflamação Doenças cardiovasculares Proteina C-reativa |
title_short |
Life course socioeconomic position and c-reactive protein : mediating role of health-risk behaviors and metabolic alterations. The brazilian longitudinal study of adult health (ELSA-Brasil) |
title_full |
Life course socioeconomic position and c-reactive protein : mediating role of health-risk behaviors and metabolic alterations. The brazilian longitudinal study of adult health (ELSA-Brasil) |
title_fullStr |
Life course socioeconomic position and c-reactive protein : mediating role of health-risk behaviors and metabolic alterations. The brazilian longitudinal study of adult health (ELSA-Brasil) |
title_full_unstemmed |
Life course socioeconomic position and c-reactive protein : mediating role of health-risk behaviors and metabolic alterations. The brazilian longitudinal study of adult health (ELSA-Brasil) |
title_sort |
Life course socioeconomic position and c-reactive protein : mediating role of health-risk behaviors and metabolic alterations. The brazilian longitudinal study of adult health (ELSA-Brasil) |
author |
Camelo, Lidyane do Valle |
author_facet |
Camelo, Lidyane do Valle Giatti, Luana Neves, Jorge Alexandre Barbosa Lotufo, Paulo Andrade Benseñor, Isabela Judith Martins Chor, Dora Griep, Rosane Harter Fonseca, Maria de Jesus Mendes da Vidigal, Pedro Guatimosim Kawachi, Ichiro Schmidt, Maria Inês Barreto, Sandhi Maria |
author_role |
author |
author2 |
Giatti, Luana Neves, Jorge Alexandre Barbosa Lotufo, Paulo Andrade Benseñor, Isabela Judith Martins Chor, Dora Griep, Rosane Harter Fonseca, Maria de Jesus Mendes da Vidigal, Pedro Guatimosim Kawachi, Ichiro Schmidt, Maria Inês Barreto, Sandhi Maria |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Camelo, Lidyane do Valle Giatti, Luana Neves, Jorge Alexandre Barbosa Lotufo, Paulo Andrade Benseñor, Isabela Judith Martins Chor, Dora Griep, Rosane Harter Fonseca, Maria de Jesus Mendes da Vidigal, Pedro Guatimosim Kawachi, Ichiro Schmidt, Maria Inês Barreto, Sandhi Maria |
dc.subject.por.fl_str_mv |
Inflamação Doenças cardiovasculares Proteina C-reativa |
topic |
Inflamação Doenças cardiovasculares Proteina C-reativa |
description |
Background: Chronic inflammation has been postulated to be one mediating mechanism explaining the association between low socioeconomic position (SEP) and cardiovascular disease (CVD). We sought to examine the association between life course SEP and C-reactive protein (CRP) levels in adulthood, and to evaluate the extent to which health-risk behaviors and metabolic alterations mediate this association. Additionally, we explored the possible modifying influence of gender. Methods and Findings: Our analytical sample comprised 13,371 participants from ELSA-Brasil baseline, a multicenter prospective cohort study of civil servants. SEP during childhood, young adulthood, and adulthood were considered. The potential mediators between life course SEP and CRP included clusters of health-risk behaviors (smoking, low leisure time physical activity, excessive alcohol consumption), and metabolic alterations (obesity, hypertension, low HDL, hypertriglyceridemia, and diabetes). Linear regression models were performed and structural equation modeling was used to evaluate mediation Although lower childhood SEP was associated with higher levels of CRP in adult life, this association was not independent of adulthood SEP. However, CRP increased linearly with increasing number of unfavorable social circumstances during the life course (p trend ,0.001). The metabolic alterations were the most important mediator between cumulative SEP and CRP. This mediation path accounted for 49.5% of the total effect of cumulative SEP on CRP among women, but only 20.2% among men. In consequence, the portion of the total effect of cumulative SEP on CRP that was mediated by risk behaviors and metabolic alterations was higher among women (55.4%) than among men (36.8%). Conclusions: Cumulative SEP across life span was associated with elevated systemic inflammation in adulthood. Although health-risk behaviors and metabolic alterations were important mediators of this association, a sizable fraction of this association was not mediated by these factors, suggesting that other pathways might play a role, especially among men. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-11-19T02:39:44Z |
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PLoS ONE. San Francisco. Vol. 9, no. 10 (Oct. 2014), e108426, 12 p. |
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