Effects of Bauhinia forficata tea on oxidative stress and liver damage in diabetic mice

• Autor(a) principal: Salgueiro, Andréia Caroline Fernandes
• Data de Publicação: 2015
• Outros Autores: Folmer, Vanderlei, Silva, Marianne Pires da, Mendez, Andreas Sebastian Loureiro, Zemolin, Ana Paula Pegoraro, Posser, Thaís, Franco, Jeferson Luis, Puntel, Robson Luiz, Puntel, Gustavo Orione
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/182698
• topic: Farmácia

This study was designed to evaluate the effects of Bauhinia forficata Link subsp. pruinosa (BF) tea on oxidative stress and liver damage in streptozotocin (STZ)-induced diabetic mice. Diabetic male mice have remained 30 days without any treatment. BF treatment started on day 31 and continued for 21 days as a drinking-water substitute.We evaluated (1) BF chemical composition; (2) glucose levels; (3) liver/bodyweight ratio and liver transaminases; (4) reactive oxygen species (ROS), lipid peroxidation, and protein carbonylation in liver; (5) superoxide dismutase (SOD) and catalase (CAT) activities in liver; (6) -aminolevulinate dehydratase (-ALA-D) and nonprotein thiols (NPSH) in liver; (7) Nrf2, NQO-1, and HSP70 levels in liver and pancreas. Phytochemical analyses identified four phenols compounds. Diabetic mice present high levels of NQO-1 in pancreas, increased levels of ROS and lipid peroxidation in liver, and decrease in CAT activity. BF treatment normalized all these parameters. BF did not normalize hyperglycemia, liver/body weight ratio, aspartate aminotransferase, protein carbonyl, NPSH levels, and -ALA-D activity. The raised oxidative stress seems to be a potential mechanism involved in liver damage in hyperglycemic conditions. Our results indicated that BF protective effect could be attributed to its antioxidant capacity, more than a hypoglycemic potential.