Chemical composition and hypotensive effect of Campomanesia xanthocarpa
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/172574 |
Resumo: | Campomanesia xanthocarpa is known in Brazil as Guabiroba and is popularly used for various diseases, such as inflammatory, renal, and digestive diseases and dyslipidemia. The aim of the study was to analyze the chemical composition and investigate the effects of aqueous extract of C. xanthocarpa on the blood pressure of normotensive rats, analyzing the possible action mechanism using experimental and in silico procedures.The extract was evaluated for total phenolic compounds and total flavonoid content. The chemical components were determined by HPLC analyses. Systolic and diastolic blood pressure and heart rate were measured with extract and drugs administration. The leaves of C. xanthocarpa presented the relevant content of phenolics and flavonoids, and we suggested the presence of chlorogenic acid, gallic acid, quercetin, and theobromine. The acute administration of aqueous extract of C. xanthocarpa has a dose-dependent hypotensive effect in normotensive rats, suggesting that the action mechanism may be mediated through the renin-angiotensin system by AT1 receptor blockade and sympathetic autonomic response. Docking studies showed models that indicated an interaction between chlorogenic acid and quercetin with the AT1 receptor (AT1R) active site.The findings of these docking studies suggest the potential of C. xanthocarpa constituents for use as preventive agents for blood pressure. |
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Sant'Anna, Liane SantarianoMerlugo, LiaraEhle, Catrine SantosLimberger, JéssicaFernandes, Maquelen BlancoSantos, Marí CastroMendez, Andreas Sebastian LoureiroPaula, Fávero ReisdorferMoreira, Cleci Menezes2018-02-16T02:29:29Z20161741-427Xhttp://hdl.handle.net/10183/172574001022724Campomanesia xanthocarpa is known in Brazil as Guabiroba and is popularly used for various diseases, such as inflammatory, renal, and digestive diseases and dyslipidemia. The aim of the study was to analyze the chemical composition and investigate the effects of aqueous extract of C. xanthocarpa on the blood pressure of normotensive rats, analyzing the possible action mechanism using experimental and in silico procedures.The extract was evaluated for total phenolic compounds and total flavonoid content. The chemical components were determined by HPLC analyses. Systolic and diastolic blood pressure and heart rate were measured with extract and drugs administration. The leaves of C. xanthocarpa presented the relevant content of phenolics and flavonoids, and we suggested the presence of chlorogenic acid, gallic acid, quercetin, and theobromine. The acute administration of aqueous extract of C. xanthocarpa has a dose-dependent hypotensive effect in normotensive rats, suggesting that the action mechanism may be mediated through the renin-angiotensin system by AT1 receptor blockade and sympathetic autonomic response. Docking studies showed models that indicated an interaction between chlorogenic acid and quercetin with the AT1 receptor (AT1R) active site.The findings of these docking studies suggest the potential of C. xanthocarpa constituents for use as preventive agents for blood pressure.application/pdfengEvidence-based complementary and alternative medicine : eCAM. [New York]. Vol. 2017 (2017), ID 1591762, [11 p.]Composição químicaCampomanesia xanthocarpaHipotensãoChemical composition and hypotensive effect of Campomanesia xanthocarpaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001022724.pdf001022724.pdfTexto completo (inglês)application/pdf3248900http://www.lume.ufrgs.br/bitstream/10183/172574/1/001022724.pdfbe1994d9c0393eba1b6adc6269fef2feMD51TEXT001022724.pdf.txt001022724.pdf.txtExtracted Texttext/plain47701http://www.lume.ufrgs.br/bitstream/10183/172574/2/001022724.pdf.txt997c3e9117753454c29f5e3e1bdb3af0MD52THUMBNAIL001022724.pdf.jpg001022724.pdf.jpgGenerated Thumbnailimage/jpeg1791http://www.lume.ufrgs.br/bitstream/10183/172574/3/001022724.pdf.jpgc2e4ad7da103838e82fe03de77d5e99aMD5310183/1725742018-10-29 07:39:56.495oai:www.lume.ufrgs.br:10183/172574Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-29T10:39:56Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Chemical composition and hypotensive effect of Campomanesia xanthocarpa |
title |
Chemical composition and hypotensive effect of Campomanesia xanthocarpa |
spellingShingle |
Chemical composition and hypotensive effect of Campomanesia xanthocarpa Sant'Anna, Liane Santariano Composição química Campomanesia xanthocarpa Hipotensão |
title_short |
Chemical composition and hypotensive effect of Campomanesia xanthocarpa |
title_full |
Chemical composition and hypotensive effect of Campomanesia xanthocarpa |
title_fullStr |
Chemical composition and hypotensive effect of Campomanesia xanthocarpa |
title_full_unstemmed |
Chemical composition and hypotensive effect of Campomanesia xanthocarpa |
title_sort |
Chemical composition and hypotensive effect of Campomanesia xanthocarpa |
author |
Sant'Anna, Liane Santariano |
author_facet |
Sant'Anna, Liane Santariano Merlugo, Liara Ehle, Catrine Santos Limberger, Jéssica Fernandes, Maquelen Blanco Santos, Marí Castro Mendez, Andreas Sebastian Loureiro Paula, Fávero Reisdorfer Moreira, Cleci Menezes |
author_role |
author |
author2 |
Merlugo, Liara Ehle, Catrine Santos Limberger, Jéssica Fernandes, Maquelen Blanco Santos, Marí Castro Mendez, Andreas Sebastian Loureiro Paula, Fávero Reisdorfer Moreira, Cleci Menezes |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sant'Anna, Liane Santariano Merlugo, Liara Ehle, Catrine Santos Limberger, Jéssica Fernandes, Maquelen Blanco Santos, Marí Castro Mendez, Andreas Sebastian Loureiro Paula, Fávero Reisdorfer Moreira, Cleci Menezes |
dc.subject.por.fl_str_mv |
Composição química Campomanesia xanthocarpa Hipotensão |
topic |
Composição química Campomanesia xanthocarpa Hipotensão |
description |
Campomanesia xanthocarpa is known in Brazil as Guabiroba and is popularly used for various diseases, such as inflammatory, renal, and digestive diseases and dyslipidemia. The aim of the study was to analyze the chemical composition and investigate the effects of aqueous extract of C. xanthocarpa on the blood pressure of normotensive rats, analyzing the possible action mechanism using experimental and in silico procedures.The extract was evaluated for total phenolic compounds and total flavonoid content. The chemical components were determined by HPLC analyses. Systolic and diastolic blood pressure and heart rate were measured with extract and drugs administration. The leaves of C. xanthocarpa presented the relevant content of phenolics and flavonoids, and we suggested the presence of chlorogenic acid, gallic acid, quercetin, and theobromine. The acute administration of aqueous extract of C. xanthocarpa has a dose-dependent hypotensive effect in normotensive rats, suggesting that the action mechanism may be mediated through the renin-angiotensin system by AT1 receptor blockade and sympathetic autonomic response. Docking studies showed models that indicated an interaction between chlorogenic acid and quercetin with the AT1 receptor (AT1R) active site.The findings of these docking studies suggest the potential of C. xanthocarpa constituents for use as preventive agents for blood pressure. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2018-02-16T02:29:29Z |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/172574 |
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1741-427X |
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001022724 |
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http://hdl.handle.net/10183/172574 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Evidence-based complementary and alternative medicine : eCAM. [New York]. Vol. 2017 (2017), ID 1591762, [11 p.] |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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