Risk factors for jaw osteoradionecrosis : a case control study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/271162 |
Resumo: | There are divergences among studies regarding features associated to increased risk of osteoradionecrosis (ORN). Our objective was to identify factors that predispose to the development of ORN of the jaw. This was a retrospective, hospital-based, case-control study involving patients with head and neck cancer who had been treated with ≥ 60 Gy external radiotherapy (RT) to the jaw. A total of 19 cases of ORN and 43 controls were included. The patients’ demographic data, tumor type, staging, treatment and outcome information, and pre-treatment oral status were collected. Univariate analysis showed that the oral cavity/oropharynx sites were associated with 9.77-fold increased risk of ORN development compared to other sites (p = 0.005). Being an active smoker was associated with 3.95-fold increased risk of ORN development (p = 0.01). A tendency towards increased risk of ORN was observed particularly when tooth extraction occurred after RT (odds ratio (OR): 3.04; p = 0.08). Multivariable analysis showed that tumor site was the only significant risk factor (OR: 21.03, p = 0.01). The oral and oropharyngeal primary site is an important risk factor for ORN. Dental extraction, which did not occur in 28% of the sample, was not an essential event for ORN development. |
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Girardi, Fábio MuradasWagner, Vivian PetersenMartins, Manoela DominguesAbentroth, Aliende LenglerHauth, Luiz AlbertoKraether Neto, LéoMergen, CristianMatiello, Juliana2024-01-26T04:47:23Z20221806-8324http://hdl.handle.net/10183/271162001195112There are divergences among studies regarding features associated to increased risk of osteoradionecrosis (ORN). Our objective was to identify factors that predispose to the development of ORN of the jaw. This was a retrospective, hospital-based, case-control study involving patients with head and neck cancer who had been treated with ≥ 60 Gy external radiotherapy (RT) to the jaw. A total of 19 cases of ORN and 43 controls were included. The patients’ demographic data, tumor type, staging, treatment and outcome information, and pre-treatment oral status were collected. Univariate analysis showed that the oral cavity/oropharynx sites were associated with 9.77-fold increased risk of ORN development compared to other sites (p = 0.005). Being an active smoker was associated with 3.95-fold increased risk of ORN development (p = 0.01). A tendency towards increased risk of ORN was observed particularly when tooth extraction occurred after RT (odds ratio (OR): 3.04; p = 0.08). Multivariable analysis showed that tumor site was the only significant risk factor (OR: 21.03, p = 0.01). The oral and oropharyngeal primary site is an important risk factor for ORN. Dental extraction, which did not occur in 28% of the sample, was not an essential event for ORN development.application/pdfengBrazilian oral research. São Paulo. Vol. 36, (2022), e132, 10 p.Fatores de riscoOsteorradionecroseEstudos de casos e controlesNeoplasias bucaisRisk factorsOsteoradionecrosisCase-control studiesMouth neoplasmsRisk factors for jaw osteoradionecrosis : a case control studyinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001195112.pdf.txt001195112.pdf.txtExtracted Texttext/plain37941http://www.lume.ufrgs.br/bitstream/10183/271162/2/001195112.pdf.txt6a865aa19b127c285472fbb832f3af8dMD52ORIGINAL001195112.pdfTexto completo (inglês)application/pdf322299http://www.lume.ufrgs.br/bitstream/10183/271162/1/001195112.pdf6611f131eacc0059050b818f25b1cac2MD5110183/2711622024-01-27 06:02:08.58311oai:www.lume.ufrgs.br:10183/271162Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-01-27T08:02:08Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Risk factors for jaw osteoradionecrosis : a case control study |
title |
Risk factors for jaw osteoradionecrosis : a case control study |
spellingShingle |
Risk factors for jaw osteoradionecrosis : a case control study Girardi, Fábio Muradas Fatores de risco Osteorradionecrose Estudos de casos e controles Neoplasias bucais Risk factors Osteoradionecrosis Case-control studies Mouth neoplasms |
title_short |
Risk factors for jaw osteoradionecrosis : a case control study |
title_full |
Risk factors for jaw osteoradionecrosis : a case control study |
title_fullStr |
Risk factors for jaw osteoradionecrosis : a case control study |
title_full_unstemmed |
Risk factors for jaw osteoradionecrosis : a case control study |
title_sort |
Risk factors for jaw osteoradionecrosis : a case control study |
author |
Girardi, Fábio Muradas |
author_facet |
Girardi, Fábio Muradas Wagner, Vivian Petersen Martins, Manoela Domingues Abentroth, Aliende Lengler Hauth, Luiz Alberto Kraether Neto, Léo Mergen, Cristian Matiello, Juliana |
author_role |
author |
author2 |
Wagner, Vivian Petersen Martins, Manoela Domingues Abentroth, Aliende Lengler Hauth, Luiz Alberto Kraether Neto, Léo Mergen, Cristian Matiello, Juliana |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Girardi, Fábio Muradas Wagner, Vivian Petersen Martins, Manoela Domingues Abentroth, Aliende Lengler Hauth, Luiz Alberto Kraether Neto, Léo Mergen, Cristian Matiello, Juliana |
dc.subject.por.fl_str_mv |
Fatores de risco Osteorradionecrose Estudos de casos e controles Neoplasias bucais |
topic |
Fatores de risco Osteorradionecrose Estudos de casos e controles Neoplasias bucais Risk factors Osteoradionecrosis Case-control studies Mouth neoplasms |
dc.subject.eng.fl_str_mv |
Risk factors Osteoradionecrosis Case-control studies Mouth neoplasms |
description |
There are divergences among studies regarding features associated to increased risk of osteoradionecrosis (ORN). Our objective was to identify factors that predispose to the development of ORN of the jaw. This was a retrospective, hospital-based, case-control study involving patients with head and neck cancer who had been treated with ≥ 60 Gy external radiotherapy (RT) to the jaw. A total of 19 cases of ORN and 43 controls were included. The patients’ demographic data, tumor type, staging, treatment and outcome information, and pre-treatment oral status were collected. Univariate analysis showed that the oral cavity/oropharynx sites were associated with 9.77-fold increased risk of ORN development compared to other sites (p = 0.005). Being an active smoker was associated with 3.95-fold increased risk of ORN development (p = 0.01). A tendency towards increased risk of ORN was observed particularly when tooth extraction occurred after RT (odds ratio (OR): 3.04; p = 0.08). Multivariable analysis showed that tumor site was the only significant risk factor (OR: 21.03, p = 0.01). The oral and oropharyngeal primary site is an important risk factor for ORN. Dental extraction, which did not occur in 28% of the sample, was not an essential event for ORN development. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
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2024-01-26T04:47:23Z |
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http://hdl.handle.net/10183/271162 |
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http://hdl.handle.net/10183/271162 |
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eng |
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Brazilian oral research. São Paulo. Vol. 36, (2022), e132, 10 p. |
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openAccess |
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