Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion : a case-control study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/253172 |
Resumo: | BACKGROUND: Because normal male sexual differentiation is more complex than normal female sexual differentiation, there are more cases of disorders of sex development (DSDs) with 46,XY karyotype that have unclear etiology. However, Leydig and Sertoli cell markers are rarely used in distinguishing such individuals. OBJECTIVES: To evaluate the function of Leydig and Sertoli cells in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion. STUDY DESIGN AND SETTING: Case-control study with 77 patients, including eight with partial androgen insensitivity syndrome, eight with 5α-reductase deficiency type 2 (5ARD2) and 19 with idiopathic 46,XY DSD, and 42 healthy controls, from the Interdisciplinary Study Group for Sex Determination and Differentiation (GIEDDS), at the State University of Campinas (UNICAMP), Campinas, Brazil. METHODS: Baseline levels of gonadotropins, anti-Müllerian hormone (AMH), inhibin B, insulin-like 3 (INSL3), testosterone and dihydrotestosterone in cases, and AMH, inhibin B, and INSL3 levels in controls, were assessed. RESULTS: There was no significant difference in age between cases and controls (P = 0.595). AMH and inhibin B levels were significantly lower in cases than in controls (P = 0.031 and P < 0.001, respectively). INSL3 levels were significantly higher in cases than in controls (P = 0.003). Inhibin B levels were lower in 5ARD2 patients (P = 0.045) and idiopathic patients (P = 0.001), in separate comparisons with the controls. CONCLUSION: According to our findings, we can speculate that inhibin B levels may be used to differentiate among DSD cases. |
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Guaragna Filho, GuilhermeCalixto, Antônio RamosAstur, Anna Beatriz Lima do VallePaula, Georgette Beatriz deOliveira, Laurione Cândido deMorcillo, André MorenoGonçalves, Ezequiel MoreiraMello, Maricilda Palandi deGuerra, Andrea Trevas MacielGuerra Júnior, Gil2022-12-24T05:05:32Z20221516-3180http://hdl.handle.net/10183/253172001156820BACKGROUND: Because normal male sexual differentiation is more complex than normal female sexual differentiation, there are more cases of disorders of sex development (DSDs) with 46,XY karyotype that have unclear etiology. However, Leydig and Sertoli cell markers are rarely used in distinguishing such individuals. OBJECTIVES: To evaluate the function of Leydig and Sertoli cells in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion. STUDY DESIGN AND SETTING: Case-control study with 77 patients, including eight with partial androgen insensitivity syndrome, eight with 5α-reductase deficiency type 2 (5ARD2) and 19 with idiopathic 46,XY DSD, and 42 healthy controls, from the Interdisciplinary Study Group for Sex Determination and Differentiation (GIEDDS), at the State University of Campinas (UNICAMP), Campinas, Brazil. METHODS: Baseline levels of gonadotropins, anti-Müllerian hormone (AMH), inhibin B, insulin-like 3 (INSL3), testosterone and dihydrotestosterone in cases, and AMH, inhibin B, and INSL3 levels in controls, were assessed. RESULTS: There was no significant difference in age between cases and controls (P = 0.595). AMH and inhibin B levels were significantly lower in cases than in controls (P = 0.031 and P < 0.001, respectively). INSL3 levels were significantly higher in cases than in controls (P = 0.003). Inhibin B levels were lower in 5ARD2 patients (P = 0.045) and idiopathic patients (P = 0.001), in separate comparisons with the controls. CONCLUSION: According to our findings, we can speculate that inhibin B levels may be used to differentiate among DSD cases.application/pdfengSão Paulo medical journal. São Paulo. Vol. 140, no. 2 (Mar./Apr. 2022), p. 163-170InibinasTranstornos do desenvolvimento sexualCélulas de SertoliCélulas intersticiais do testículoSomatomedinasHormônio antimüllerianoInhibin BDisorders of sex developmentSertoli cellsLeydig cellsDSDAmbiguous genitaliINSL3AMHLeydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion : a case-control studyinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001156820.pdf.txt001156820.pdf.txtExtracted Texttext/plain45886http://www.lume.ufrgs.br/bitstream/10183/253172/2/001156820.pdf.txt7dab91550a7140325bd39b5c814488feMD52ORIGINAL001156820.pdfTexto completo (inglês)application/pdf214186http://www.lume.ufrgs.br/bitstream/10183/253172/1/001156820.pdf490a61286f48de2003873b0aa6dacfc1MD5110183/2531722024-01-06 04:36:54.550635oai:www.lume.ufrgs.br:10183/253172Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-01-06T06:36:54Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion : a case-control study |
title |
Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion : a case-control study |
spellingShingle |
Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion : a case-control study Guaragna Filho, Guilherme Inibinas Transtornos do desenvolvimento sexual Células de Sertoli Células intersticiais do testículo Somatomedinas Hormônio antimülleriano Inhibin B Disorders of sex development Sertoli cells Leydig cells DSD Ambiguous genitali INSL3 AMH |
title_short |
Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion : a case-control study |
title_full |
Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion : a case-control study |
title_fullStr |
Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion : a case-control study |
title_full_unstemmed |
Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion : a case-control study |
title_sort |
Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion : a case-control study |
author |
Guaragna Filho, Guilherme |
author_facet |
Guaragna Filho, Guilherme Calixto, Antônio Ramos Astur, Anna Beatriz Lima do Valle Paula, Georgette Beatriz de Oliveira, Laurione Cândido de Morcillo, André Moreno Gonçalves, Ezequiel Moreira Mello, Maricilda Palandi de Guerra, Andrea Trevas Maciel Guerra Júnior, Gil |
author_role |
author |
author2 |
Calixto, Antônio Ramos Astur, Anna Beatriz Lima do Valle Paula, Georgette Beatriz de Oliveira, Laurione Cândido de Morcillo, André Moreno Gonçalves, Ezequiel Moreira Mello, Maricilda Palandi de Guerra, Andrea Trevas Maciel Guerra Júnior, Gil |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Guaragna Filho, Guilherme Calixto, Antônio Ramos Astur, Anna Beatriz Lima do Valle Paula, Georgette Beatriz de Oliveira, Laurione Cândido de Morcillo, André Moreno Gonçalves, Ezequiel Moreira Mello, Maricilda Palandi de Guerra, Andrea Trevas Maciel Guerra Júnior, Gil |
dc.subject.por.fl_str_mv |
Inibinas Transtornos do desenvolvimento sexual Células de Sertoli Células intersticiais do testículo Somatomedinas Hormônio antimülleriano |
topic |
Inibinas Transtornos do desenvolvimento sexual Células de Sertoli Células intersticiais do testículo Somatomedinas Hormônio antimülleriano Inhibin B Disorders of sex development Sertoli cells Leydig cells DSD Ambiguous genitali INSL3 AMH |
dc.subject.eng.fl_str_mv |
Inhibin B Disorders of sex development Sertoli cells Leydig cells DSD Ambiguous genitali INSL3 AMH |
description |
BACKGROUND: Because normal male sexual differentiation is more complex than normal female sexual differentiation, there are more cases of disorders of sex development (DSDs) with 46,XY karyotype that have unclear etiology. However, Leydig and Sertoli cell markers are rarely used in distinguishing such individuals. OBJECTIVES: To evaluate the function of Leydig and Sertoli cells in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion. STUDY DESIGN AND SETTING: Case-control study with 77 patients, including eight with partial androgen insensitivity syndrome, eight with 5α-reductase deficiency type 2 (5ARD2) and 19 with idiopathic 46,XY DSD, and 42 healthy controls, from the Interdisciplinary Study Group for Sex Determination and Differentiation (GIEDDS), at the State University of Campinas (UNICAMP), Campinas, Brazil. METHODS: Baseline levels of gonadotropins, anti-Müllerian hormone (AMH), inhibin B, insulin-like 3 (INSL3), testosterone and dihydrotestosterone in cases, and AMH, inhibin B, and INSL3 levels in controls, were assessed. RESULTS: There was no significant difference in age between cases and controls (P = 0.595). AMH and inhibin B levels were significantly lower in cases than in controls (P = 0.031 and P < 0.001, respectively). INSL3 levels were significantly higher in cases than in controls (P = 0.003). Inhibin B levels were lower in 5ARD2 patients (P = 0.045) and idiopathic patients (P = 0.001), in separate comparisons with the controls. CONCLUSION: According to our findings, we can speculate that inhibin B levels may be used to differentiate among DSD cases. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-12-24T05:05:32Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
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http://hdl.handle.net/10183/253172 |
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1516-3180 |
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001156820 |
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http://hdl.handle.net/10183/253172 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
São Paulo medical journal. São Paulo. Vol. 140, no. 2 (Mar./Apr. 2022), p. 163-170 |
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