Pharmacology and toxicology of diphenyl diselenide in several biological models

Detalhes bibliográficos
Autor(a) principal: Rosa, Renato Moreira
Data de Publicação: 2007
Outros Autores: Roesler, Rafael, Braga, Antonio Luiz, Saffi, Jenifer, Henriques, João Antonio Pêgas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/21212
Resumo: The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in several in vitro and in vivo systems, and thus has a protective effect against hepatic, renal and gastric injuries, in addition to its neuroprotective activity. The activity of the compound on the central nervous system has been studied since DPDS has lipophilic characteristics, increasing adenylyl cyclase activity and inhibiting glutamate and MK-801 binding to rat synaptic membranes. Systemic administration facilitates the formation of long-term object recognition memory in mice and has a protective effect against brain ischemia and on reserpine-induced orofacial dyskinesia in rats. On the other hand, DPDS may be toxic, mainly because of its interaction with thiol groups. In the yeast Saccharomyces cerevisiae, the molecule acts as a pro-oxidant by depleting free glutathione. Administration to mice during cadmium intoxication has the opposite effect, reducing oxidative stress in various tissues. DPDS is a potent inhibitor of δ-aminolevulinate dehydratase and chronic exposure to high doses of this compound has central effects on mouse brain, as well as liver and renal toxicity. Genotoxicity of this compound has been assessed in bacteria, haploid and diploid yeast and in a tumor cell line.
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spelling Rosa, Renato MoreiraRoesler, RafaelBraga, Antonio LuizSaffi, JeniferHenriques, João Antonio Pêgas2010-04-24T04:15:45Z20070100-879Xhttp://hdl.handle.net/10183/21212000615300The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in several in vitro and in vivo systems, and thus has a protective effect against hepatic, renal and gastric injuries, in addition to its neuroprotective activity. The activity of the compound on the central nervous system has been studied since DPDS has lipophilic characteristics, increasing adenylyl cyclase activity and inhibiting glutamate and MK-801 binding to rat synaptic membranes. Systemic administration facilitates the formation of long-term object recognition memory in mice and has a protective effect against brain ischemia and on reserpine-induced orofacial dyskinesia in rats. On the other hand, DPDS may be toxic, mainly because of its interaction with thiol groups. In the yeast Saccharomyces cerevisiae, the molecule acts as a pro-oxidant by depleting free glutathione. Administration to mice during cadmium intoxication has the opposite effect, reducing oxidative stress in various tissues. DPDS is a potent inhibitor of δ-aminolevulinate dehydratase and chronic exposure to high doses of this compound has central effects on mouse brain, as well as liver and renal toxicity. Genotoxicity of this compound has been assessed in bacteria, haploid and diploid yeast and in a tumor cell line.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 40, no. 10 (Out. 2007), p. 1287-1304AntioxidantesNeuroproteçãoSacharomyces cerevisae : MutageneseToxicologiaDiphenyl diselenideOrganoseleniumAntioxidantsNeuroprotectionSaccharomyces cerevisiaeMutagenesisPharmacology and toxicology of diphenyl diselenide in several biological modelsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000615300.pdf000615300.pdfTexto completo (inglês)application/pdf655494http://www.lume.ufrgs.br/bitstream/10183/21212/1/000615300.pdf8b7ba7a2dafeef4cce9c81cea88c319cMD51TEXT000615300.pdf.txt000615300.pdf.txtExtracted Texttext/plain65784http://www.lume.ufrgs.br/bitstream/10183/21212/2/000615300.pdf.txt0dbd31c495c488850e9aff383ed38a84MD52THUMBNAIL000615300.pdf.jpg000615300.pdf.jpgGenerated Thumbnailimage/jpeg1659http://www.lume.ufrgs.br/bitstream/10183/21212/3/000615300.pdf.jpg49e53d24c292c3c3ebb3e6209a76923aMD5310183/212122019-06-20 02:35:12.121709oai:www.lume.ufrgs.br:10183/21212Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-06-20T05:35:12Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Pharmacology and toxicology of diphenyl diselenide in several biological models
title Pharmacology and toxicology of diphenyl diselenide in several biological models
spellingShingle Pharmacology and toxicology of diphenyl diselenide in several biological models
Rosa, Renato Moreira
Antioxidantes
Neuroproteção
Sacharomyces cerevisae : Mutagenese
Toxicologia
Diphenyl diselenide
Organoselenium
Antioxidants
Neuroprotection
Saccharomyces cerevisiae
Mutagenesis
title_short Pharmacology and toxicology of diphenyl diselenide in several biological models
title_full Pharmacology and toxicology of diphenyl diselenide in several biological models
title_fullStr Pharmacology and toxicology of diphenyl diselenide in several biological models
title_full_unstemmed Pharmacology and toxicology of diphenyl diselenide in several biological models
title_sort Pharmacology and toxicology of diphenyl diselenide in several biological models
author Rosa, Renato Moreira
author_facet Rosa, Renato Moreira
Roesler, Rafael
Braga, Antonio Luiz
Saffi, Jenifer
Henriques, João Antonio Pêgas
author_role author
author2 Roesler, Rafael
Braga, Antonio Luiz
Saffi, Jenifer
Henriques, João Antonio Pêgas
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rosa, Renato Moreira
Roesler, Rafael
Braga, Antonio Luiz
Saffi, Jenifer
Henriques, João Antonio Pêgas
dc.subject.por.fl_str_mv Antioxidantes
Neuroproteção
Sacharomyces cerevisae : Mutagenese
Toxicologia
topic Antioxidantes
Neuroproteção
Sacharomyces cerevisae : Mutagenese
Toxicologia
Diphenyl diselenide
Organoselenium
Antioxidants
Neuroprotection
Saccharomyces cerevisiae
Mutagenesis
dc.subject.eng.fl_str_mv Diphenyl diselenide
Organoselenium
Antioxidants
Neuroprotection
Saccharomyces cerevisiae
Mutagenesis
description The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in several in vitro and in vivo systems, and thus has a protective effect against hepatic, renal and gastric injuries, in addition to its neuroprotective activity. The activity of the compound on the central nervous system has been studied since DPDS has lipophilic characteristics, increasing adenylyl cyclase activity and inhibiting glutamate and MK-801 binding to rat synaptic membranes. Systemic administration facilitates the formation of long-term object recognition memory in mice and has a protective effect against brain ischemia and on reserpine-induced orofacial dyskinesia in rats. On the other hand, DPDS may be toxic, mainly because of its interaction with thiol groups. In the yeast Saccharomyces cerevisiae, the molecule acts as a pro-oxidant by depleting free glutathione. Administration to mice during cadmium intoxication has the opposite effect, reducing oxidative stress in various tissues. DPDS is a potent inhibitor of δ-aminolevulinate dehydratase and chronic exposure to high doses of this compound has central effects on mouse brain, as well as liver and renal toxicity. Genotoxicity of this compound has been assessed in bacteria, haploid and diploid yeast and in a tumor cell line.
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dc.relation.ispartof.pt_BR.fl_str_mv Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 40, no. 10 (Out. 2007), p. 1287-1304
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