Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid

Detalhes bibliográficos
Autor(a) principal: Pereira, Gabriela Garrastazu
Data de Publicação: 2013
Outros Autores: Dimer, Frantiescoli Anversa, Guterres, Silvia Stanisçuaski, Kechinski, Carolina Pereira, Granada, Jonas Eichelberger, Cardozo, Nilo Sérgio Medeiros
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/115203
Resumo: The influence of the composition and preparation method on the sol–gel transition temperature (Tsol–gel) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of Tsol–gel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the Tsol–gel values. In contrast, the addition of microparticles caused a reduction in Tsol–gel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds.
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spelling Pereira, Gabriela GarrastazuDimer, Frantiescoli AnversaGuterres, Silvia StanisçuaskiKechinski, Carolina PereiraGranada, Jonas EichelbergerCardozo, Nilo Sérgio Medeiros2015-04-11T02:01:06Z20130100-4042http://hdl.handle.net/10183/115203000956086The influence of the composition and preparation method on the sol–gel transition temperature (Tsol–gel) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of Tsol–gel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the Tsol–gel values. In contrast, the addition of microparticles caused a reduction in Tsol–gel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds.application/pdfengQuímica nova. São Paulo. Vol. 36, n. 8 (2013), p. 1121-1125CopolímerosReologiaThermoreversible gelRheologyBurn woundsFormulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acidinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000956086.pdf.txt000956086.pdf.txtExtracted Texttext/plain25809http://www.lume.ufrgs.br/bitstream/10183/115203/2/000956086.pdf.txt728fba7f8933af4f5654ebf72582c77cMD52ORIGINAL000956086.pdf000956086.pdfTexto completo (inglês)application/pdf505714http://www.lume.ufrgs.br/bitstream/10183/115203/1/000956086.pdf0a7130ae2bacc54f07fe6190bb2751dfMD51THUMBNAIL000956086.pdf.jpg000956086.pdf.jpgGenerated Thumbnailimage/jpeg1956http://www.lume.ufrgs.br/bitstream/10183/115203/3/000956086.pdf.jpgf5e0bb048845b00633589693c1d6e604MD5310183/1152032022-08-21 04:40:24.044229oai:www.lume.ufrgs.br:10183/115203Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-08-21T07:40:24Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid
title Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid
spellingShingle Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid
Pereira, Gabriela Garrastazu
Copolímeros
Reologia
Thermoreversible gel
Rheology
Burn wounds
title_short Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid
title_full Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid
title_fullStr Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid
title_full_unstemmed Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid
title_sort Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid
author Pereira, Gabriela Garrastazu
author_facet Pereira, Gabriela Garrastazu
Dimer, Frantiescoli Anversa
Guterres, Silvia Stanisçuaski
Kechinski, Carolina Pereira
Granada, Jonas Eichelberger
Cardozo, Nilo Sérgio Medeiros
author_role author
author2 Dimer, Frantiescoli Anversa
Guterres, Silvia Stanisçuaski
Kechinski, Carolina Pereira
Granada, Jonas Eichelberger
Cardozo, Nilo Sérgio Medeiros
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Gabriela Garrastazu
Dimer, Frantiescoli Anversa
Guterres, Silvia Stanisçuaski
Kechinski, Carolina Pereira
Granada, Jonas Eichelberger
Cardozo, Nilo Sérgio Medeiros
dc.subject.por.fl_str_mv Copolímeros
Reologia
topic Copolímeros
Reologia
Thermoreversible gel
Rheology
Burn wounds
dc.subject.eng.fl_str_mv Thermoreversible gel
Rheology
Burn wounds
description The influence of the composition and preparation method on the sol–gel transition temperature (Tsol–gel) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of Tsol–gel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the Tsol–gel values. In contrast, the addition of microparticles caused a reduction in Tsol–gel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-04-11T02:01:06Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/115203
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo. Vol. 36, n. 8 (2013), p. 1121-1125
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