EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/236683 |
Resumo: | Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during normal development and are also involved in carcinogenesis and cancer progression. The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mostly mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), influences gene expression involved in embryonic development and tissue differentiation. Overexpression of G9a has been observed in several cancer types, and different classes of G9a inhibitors have been developed as potential anticancer agents. Here, we review the emerging evidence suggesting the involvement of changes in G9a activity in brain tumors, namely glioblastoma (GBM), the main type of primary malignant brain cancer in adults, and medulloblastoma (MB), the most common type of malignant brain cancer in children. We also discuss the role of G9a in neuroblastoma (NB) and the drug development of G9a inhibitors. |
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Souza, Bárbara KunzlerFreire, Natália HogetopJaeger, Mariane da CunhaFarias, Caroline Brunetto deBrunetto, Algemir LunardiBrunetto, Andre TessainerRoesler, Rafael2022-04-07T04:47:52Z20211422-0067http://hdl.handle.net/10183/236683001137381Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during normal development and are also involved in carcinogenesis and cancer progression. The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mostly mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), influences gene expression involved in embryonic development and tissue differentiation. Overexpression of G9a has been observed in several cancer types, and different classes of G9a inhibitors have been developed as potential anticancer agents. Here, we review the emerging evidence suggesting the involvement of changes in G9a activity in brain tumors, namely glioblastoma (GBM), the main type of primary malignant brain cancer in adults, and medulloblastoma (MB), the most common type of malignant brain cancer in children. We also discuss the role of G9a in neuroblastoma (NB) and the drug development of G9a inhibitors.application/pdfengInternational journal of molecular sciences. Basel. Vol. 22, no. 20 (Oct. 2021), 11292, 11 p.Histona-lisina N-metiltransferaseMetilação de DNAEpigênese genéticaNeoplasias encefálicasG9aEHMT2GlioblastomaMedulloblastomaEpigeneticsBrain tumorEHMT2/G9a as an epigenetic target in pediatric and adult brain tumorsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001137381.pdf.txt001137381.pdf.txtExtracted Texttext/plain55775http://www.lume.ufrgs.br/bitstream/10183/236683/2/001137381.pdf.txt68f74b9172cd1397737e2fb29768d0a3MD52ORIGINAL001137381.pdfTexto completo (inglês)application/pdf580656http://www.lume.ufrgs.br/bitstream/10183/236683/1/001137381.pdf8ead887b57a3df3d2b174b113759d333MD5110183/2366832022-04-20 04:47:45.643673oai:www.lume.ufrgs.br:10183/236683Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-04-20T07:47:45Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors |
title |
EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors |
spellingShingle |
EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors Souza, Bárbara Kunzler Histona-lisina N-metiltransferase Metilação de DNA Epigênese genética Neoplasias encefálicas G9a EHMT2 Glioblastoma Medulloblastoma Epigenetics Brain tumor |
title_short |
EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors |
title_full |
EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors |
title_fullStr |
EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors |
title_full_unstemmed |
EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors |
title_sort |
EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors |
author |
Souza, Bárbara Kunzler |
author_facet |
Souza, Bárbara Kunzler Freire, Natália Hogetop Jaeger, Mariane da Cunha Farias, Caroline Brunetto de Brunetto, Algemir Lunardi Brunetto, Andre Tessainer Roesler, Rafael |
author_role |
author |
author2 |
Freire, Natália Hogetop Jaeger, Mariane da Cunha Farias, Caroline Brunetto de Brunetto, Algemir Lunardi Brunetto, Andre Tessainer Roesler, Rafael |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Souza, Bárbara Kunzler Freire, Natália Hogetop Jaeger, Mariane da Cunha Farias, Caroline Brunetto de Brunetto, Algemir Lunardi Brunetto, Andre Tessainer Roesler, Rafael |
dc.subject.por.fl_str_mv |
Histona-lisina N-metiltransferase Metilação de DNA Epigênese genética Neoplasias encefálicas |
topic |
Histona-lisina N-metiltransferase Metilação de DNA Epigênese genética Neoplasias encefálicas G9a EHMT2 Glioblastoma Medulloblastoma Epigenetics Brain tumor |
dc.subject.eng.fl_str_mv |
G9a EHMT2 Glioblastoma Medulloblastoma Epigenetics Brain tumor |
description |
Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during normal development and are also involved in carcinogenesis and cancer progression. The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mostly mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), influences gene expression involved in embryonic development and tissue differentiation. Overexpression of G9a has been observed in several cancer types, and different classes of G9a inhibitors have been developed as potential anticancer agents. Here, we review the emerging evidence suggesting the involvement of changes in G9a activity in brain tumors, namely glioblastoma (GBM), the main type of primary malignant brain cancer in adults, and medulloblastoma (MB), the most common type of malignant brain cancer in children. We also discuss the role of G9a in neuroblastoma (NB) and the drug development of G9a inhibitors. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-04-07T04:47:52Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/236683 |
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1422-0067 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001137381 |
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1422-0067 001137381 |
url |
http://hdl.handle.net/10183/236683 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
International journal of molecular sciences. Basel. Vol. 22, no. 20 (Oct. 2021), 11292, 11 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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