Development of an innovative formulation that associates polymeric nanocapsules and pectin for topical application
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/250471 |
Resumo: | This work aimed to developed and characterize a pectin hydrogel containing polymeric nanocapsules. This hydrogel was characterized in terms of rheological properties, drug release profile, adhesiveness, and permeation and penetration into the skin layers. For these experiments, imiquimod was used as a model drug. A pectin hydrogel without the nanocapsules and carbopol hydrogels (containing polymeric nanocapsules or not) were used as controls for the nanotechnological formulation developed. Regarding the rheological properties, the pectin hydrogel presented pseudoplastic behavior, which is suitable for topical application. The release profile study showed a more controlled drug release from the pectin hydrogel containing the nanoencapsulated imiquimod than from the other hydrogels. The adhesiveness was measured by two techniques: washability study and tensile stress study. By both techniques, the pectin hydrogel containing the polymeric nanocapsules presented as the most adhesive formulation. The penetration and permeation studies showed that the nanoencapsulated drug incorporated into the pectin hydrogel was able to penetrate the deeper layer of skin and to permeate the skin more effectively than the drug incorporated in the other formulations. |
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Gazzi, Rafaela PletschGuterres, Silvia StanisçuaskiFrank, Luiza Abrahão2022-10-27T04:52:17Z2018http://hdl.handle.net/10183/250471001094831This work aimed to developed and characterize a pectin hydrogel containing polymeric nanocapsules. This hydrogel was characterized in terms of rheological properties, drug release profile, adhesiveness, and permeation and penetration into the skin layers. For these experiments, imiquimod was used as a model drug. A pectin hydrogel without the nanocapsules and carbopol hydrogels (containing polymeric nanocapsules or not) were used as controls for the nanotechnological formulation developed. Regarding the rheological properties, the pectin hydrogel presented pseudoplastic behavior, which is suitable for topical application. The release profile study showed a more controlled drug release from the pectin hydrogel containing the nanoencapsulated imiquimod than from the other hydrogels. The adhesiveness was measured by two techniques: washability study and tensile stress study. By both techniques, the pectin hydrogel containing the polymeric nanocapsules presented as the most adhesive formulation. The penetration and permeation studies showed that the nanoencapsulated drug incorporated into the pectin hydrogel was able to penetrate the deeper layer of skin and to permeate the skin more effectively than the drug incorporated in the other formulations.application/pdfengNanocápsulas poliméricasHidrogéisImiquimodePermeação cutâneaPectin hydrogelPolymeric nanocapsulesImiquimodSkin permeationSkin adhesivenessIn vitro releaseDevelopment of an innovative formulation that associates polymeric nanocapsules and pectin for topical applicationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisUniversidade Federal do Rio Grande do SulFaculdade de FarmáciaPorto Alegre, BR-RS2018Farmáciagraduaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001094831.pdf.txt001094831.pdf.txtExtracted Texttext/plain38711http://www.lume.ufrgs.br/bitstream/10183/250471/2/001094831.pdf.txtb900315d8a78c058497e5c053fffa7f4MD52ORIGINAL001094831.pdfTexto completoapplication/pdf260859http://www.lume.ufrgs.br/bitstream/10183/250471/1/001094831.pdf080b2b1e916b3a1cbbc25192e2ab1bfbMD5110183/2504712022-10-28 04:47:45.4777oai:www.lume.ufrgs.br:10183/250471Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-10-28T07:47:45Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Development of an innovative formulation that associates polymeric nanocapsules and pectin for topical application |
title |
Development of an innovative formulation that associates polymeric nanocapsules and pectin for topical application |
spellingShingle |
Development of an innovative formulation that associates polymeric nanocapsules and pectin for topical application Gazzi, Rafaela Pletsch Nanocápsulas poliméricas Hidrogéis Imiquimode Permeação cutânea Pectin hydrogel Polymeric nanocapsules Imiquimod Skin permeation Skin adhesiveness In vitro release |
title_short |
Development of an innovative formulation that associates polymeric nanocapsules and pectin for topical application |
title_full |
Development of an innovative formulation that associates polymeric nanocapsules and pectin for topical application |
title_fullStr |
Development of an innovative formulation that associates polymeric nanocapsules and pectin for topical application |
title_full_unstemmed |
Development of an innovative formulation that associates polymeric nanocapsules and pectin for topical application |
title_sort |
Development of an innovative formulation that associates polymeric nanocapsules and pectin for topical application |
author |
Gazzi, Rafaela Pletsch |
author_facet |
Gazzi, Rafaela Pletsch |
author_role |
author |
dc.contributor.author.fl_str_mv |
Gazzi, Rafaela Pletsch |
dc.contributor.advisor1.fl_str_mv |
Guterres, Silvia Stanisçuaski |
dc.contributor.advisor-co1.fl_str_mv |
Frank, Luiza Abrahão |
contributor_str_mv |
Guterres, Silvia Stanisçuaski Frank, Luiza Abrahão |
dc.subject.por.fl_str_mv |
Nanocápsulas poliméricas Hidrogéis Imiquimode Permeação cutânea |
topic |
Nanocápsulas poliméricas Hidrogéis Imiquimode Permeação cutânea Pectin hydrogel Polymeric nanocapsules Imiquimod Skin permeation Skin adhesiveness In vitro release |
dc.subject.eng.fl_str_mv |
Pectin hydrogel Polymeric nanocapsules Imiquimod Skin permeation Skin adhesiveness In vitro release |
description |
This work aimed to developed and characterize a pectin hydrogel containing polymeric nanocapsules. This hydrogel was characterized in terms of rheological properties, drug release profile, adhesiveness, and permeation and penetration into the skin layers. For these experiments, imiquimod was used as a model drug. A pectin hydrogel without the nanocapsules and carbopol hydrogels (containing polymeric nanocapsules or not) were used as controls for the nanotechnological formulation developed. Regarding the rheological properties, the pectin hydrogel presented pseudoplastic behavior, which is suitable for topical application. The release profile study showed a more controlled drug release from the pectin hydrogel containing the nanoencapsulated imiquimod than from the other hydrogels. The adhesiveness was measured by two techniques: washability study and tensile stress study. By both techniques, the pectin hydrogel containing the polymeric nanocapsules presented as the most adhesive formulation. The penetration and permeation studies showed that the nanoencapsulated drug incorporated into the pectin hydrogel was able to penetrate the deeper layer of skin and to permeate the skin more effectively than the drug incorporated in the other formulations. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2022-10-27T04:52:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/250471 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001094831 |
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