Local regulation of antral follicle development and ovulation in monovulatory species
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/254593 |
Resumo: | The identification of mutations in the genes encoding bone morphogenetic protein 15 (BMP15) and growth and differentiation factor 9 (GDF9) associated with phenotypes of sterility or increased ovulation rate in sheep aroused interest in the study of the role of local factors in preantral and antral folliculogenesis in different species. An additive mutation in the BMP15 receptor, BMPR1b, which determines an increase in the ovulatory rate, has been introduced in several sheep breeds to increase the number of lambs born. Although these mutations indicate extremely relevant functions of these factors, the literature data on the regulation of the expression and function of these proteins and their receptors are very controversial, possibly due to differences in experimental models. The present review discusses the published data and preliminary results obtained by our group on the participation of local factors in the selection of the dominant follicle, ovulation, and follicular atresia in cattle, focusing on transforming growth factors beta and their receptors. The study of the expression pattern and the functionality of proteins produced by follicular cells and their receptors will allow increasing the knowledge about this local system, known to be involved in ovarian physiopathology and with the potential to promote contraception or increase the ovulation rate in mammals. |
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Moraes, Fabiane Pereira deMissio, DanieleLazzari, JéssicaRovani, Monique TomazeleFerreira, RogérioGoncalves, Paulo Bayard DiasGasperin, Bernardo Garziera2023-02-10T04:56:38Z20221806-9614http://hdl.handle.net/10183/254593001161734The identification of mutations in the genes encoding bone morphogenetic protein 15 (BMP15) and growth and differentiation factor 9 (GDF9) associated with phenotypes of sterility or increased ovulation rate in sheep aroused interest in the study of the role of local factors in preantral and antral folliculogenesis in different species. An additive mutation in the BMP15 receptor, BMPR1b, which determines an increase in the ovulatory rate, has been introduced in several sheep breeds to increase the number of lambs born. Although these mutations indicate extremely relevant functions of these factors, the literature data on the regulation of the expression and function of these proteins and their receptors are very controversial, possibly due to differences in experimental models. The present review discusses the published data and preliminary results obtained by our group on the participation of local factors in the selection of the dominant follicle, ovulation, and follicular atresia in cattle, focusing on transforming growth factors beta and their receptors. The study of the expression pattern and the functionality of proteins produced by follicular cells and their receptors will allow increasing the knowledge about this local system, known to be involved in ovarian physiopathology and with the potential to promote contraception or increase the ovulation rate in mammals.application/pdfengAnimal reproduction. Belo Horizonte. Vol. 19, no. 4 (2022), e20220099, 10 p.Regulação da expressão gênicaProteína morfogenética óssea 15Fator 9 de diferenciação de crescimentoFoliculogêneseOvulaçãoBovinosTransforming growth factorsDeviationOocyteLocal regulation of antral follicle development and ovulation in monovulatory speciesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001161734.pdf.txt001161734.pdf.txtExtracted Texttext/plain40740http://www.lume.ufrgs.br/bitstream/10183/254593/2/001161734.pdf.txt854108b8fb807e8e654e3a5403aa45faMD52ORIGINAL001161734.pdfTexto completo (inglês)application/pdf1241382http://www.lume.ufrgs.br/bitstream/10183/254593/1/001161734.pdf8d4b19ecef062401c7ec268bdafd1426MD5110183/2545932023-02-11 06:05:58.090383oai:www.lume.ufrgs.br:10183/254593Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-02-11T08:05:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Local regulation of antral follicle development and ovulation in monovulatory species |
title |
Local regulation of antral follicle development and ovulation in monovulatory species |
spellingShingle |
Local regulation of antral follicle development and ovulation in monovulatory species Moraes, Fabiane Pereira de Regulação da expressão gênica Proteína morfogenética óssea 15 Fator 9 de diferenciação de crescimento Foliculogênese Ovulação Bovinos Transforming growth factors Deviation Oocyte |
title_short |
Local regulation of antral follicle development and ovulation in monovulatory species |
title_full |
Local regulation of antral follicle development and ovulation in monovulatory species |
title_fullStr |
Local regulation of antral follicle development and ovulation in monovulatory species |
title_full_unstemmed |
Local regulation of antral follicle development and ovulation in monovulatory species |
title_sort |
Local regulation of antral follicle development and ovulation in monovulatory species |
author |
Moraes, Fabiane Pereira de |
author_facet |
Moraes, Fabiane Pereira de Missio, Daniele Lazzari, Jéssica Rovani, Monique Tomazele Ferreira, Rogério Goncalves, Paulo Bayard Dias Gasperin, Bernardo Garziera |
author_role |
author |
author2 |
Missio, Daniele Lazzari, Jéssica Rovani, Monique Tomazele Ferreira, Rogério Goncalves, Paulo Bayard Dias Gasperin, Bernardo Garziera |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Moraes, Fabiane Pereira de Missio, Daniele Lazzari, Jéssica Rovani, Monique Tomazele Ferreira, Rogério Goncalves, Paulo Bayard Dias Gasperin, Bernardo Garziera |
dc.subject.por.fl_str_mv |
Regulação da expressão gênica Proteína morfogenética óssea 15 Fator 9 de diferenciação de crescimento Foliculogênese Ovulação Bovinos |
topic |
Regulação da expressão gênica Proteína morfogenética óssea 15 Fator 9 de diferenciação de crescimento Foliculogênese Ovulação Bovinos Transforming growth factors Deviation Oocyte |
dc.subject.eng.fl_str_mv |
Transforming growth factors Deviation Oocyte |
description |
The identification of mutations in the genes encoding bone morphogenetic protein 15 (BMP15) and growth and differentiation factor 9 (GDF9) associated with phenotypes of sterility or increased ovulation rate in sheep aroused interest in the study of the role of local factors in preantral and antral folliculogenesis in different species. An additive mutation in the BMP15 receptor, BMPR1b, which determines an increase in the ovulatory rate, has been introduced in several sheep breeds to increase the number of lambs born. Although these mutations indicate extremely relevant functions of these factors, the literature data on the regulation of the expression and function of these proteins and their receptors are very controversial, possibly due to differences in experimental models. The present review discusses the published data and preliminary results obtained by our group on the participation of local factors in the selection of the dominant follicle, ovulation, and follicular atresia in cattle, focusing on transforming growth factors beta and their receptors. The study of the expression pattern and the functionality of proteins produced by follicular cells and their receptors will allow increasing the knowledge about this local system, known to be involved in ovarian physiopathology and with the potential to promote contraception or increase the ovulation rate in mammals. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-02-10T04:56:38Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
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http://hdl.handle.net/10183/254593 |
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1806-9614 |
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001161734 |
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http://hdl.handle.net/10183/254593 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Animal reproduction. Belo Horizonte. Vol. 19, no. 4 (2022), e20220099, 10 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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