Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis : a case report
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/229331 |
Resumo: | Hepatic sinusoidal obstruction syndrome (HSOS) is a hepatic vascular disease histologically characterized by edema, necrosis, detachment of endothelial cells in small sinusoidal hepatic and interlobular veins and intrahepatic congestion, which leads to portal hypertension and liver dysfunction. In the Western world, most HSOS cases are associated with myeloablative pretreatment in a hematopoietic stem cell transplantation setting. Here we report a case of a 54 years old female patient, otherwise healthy, with no history of alcoholic ingestion, who presented with jaundice and signs of portal hypertension, including ascites and bilateral pleural effusion. She had no history of liver disease and denied any other risk factor for liver injury, except Senecio brasiliensis ingestion as a tea, prescribed as a therapy for menopause. Acute viral hepatitis and thrombosis of the portal system were excluded in complementary investigation, as well as sepsis, metastatic malignancy and other liver diseases, setting a RUCAM score of 6. Computed tomography demonstrated a diffuse liver parenchymal heterogeneity (in mosaic) and an extensive portosystemic collateral venous circulation, in the absence of any noticeable venous obstruction. HSOS diagnosis was confirmed through a liver biopsy. During the following-up period, patient developed refractory pleural effusion, requiring hemodialysis. Right before starting anticoagulation, she presented with abdominal pain and distention, with findings compatible of mesenteric ischemia by computed tomography. A laparotomy was performed, showing an 80 cm segment of small bowel ischemia, and resection was done. She died one day after as a result from a septic shock refractory to treatment. The presented case was related to oral intake of S. brasiliensis, a plant containing pyrrolidine alkaloids, which are one of the main causes of HSOS in the East, highlighting the risk of liver injury with herbs intake. |
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Barcelos, Samantha Thifani AlrutzDall’Oglio, Vincent MarinAraujo, Alexandre deCerski, Carlos Thadeu SchmidtÁlvares-da-Silva, Mário Reis2021-09-01T04:26:37Z20211665-2681http://hdl.handle.net/10183/229331001130148Hepatic sinusoidal obstruction syndrome (HSOS) is a hepatic vascular disease histologically characterized by edema, necrosis, detachment of endothelial cells in small sinusoidal hepatic and interlobular veins and intrahepatic congestion, which leads to portal hypertension and liver dysfunction. In the Western world, most HSOS cases are associated with myeloablative pretreatment in a hematopoietic stem cell transplantation setting. Here we report a case of a 54 years old female patient, otherwise healthy, with no history of alcoholic ingestion, who presented with jaundice and signs of portal hypertension, including ascites and bilateral pleural effusion. She had no history of liver disease and denied any other risk factor for liver injury, except Senecio brasiliensis ingestion as a tea, prescribed as a therapy for menopause. Acute viral hepatitis and thrombosis of the portal system were excluded in complementary investigation, as well as sepsis, metastatic malignancy and other liver diseases, setting a RUCAM score of 6. Computed tomography demonstrated a diffuse liver parenchymal heterogeneity (in mosaic) and an extensive portosystemic collateral venous circulation, in the absence of any noticeable venous obstruction. HSOS diagnosis was confirmed through a liver biopsy. During the following-up period, patient developed refractory pleural effusion, requiring hemodialysis. Right before starting anticoagulation, she presented with abdominal pain and distention, with findings compatible of mesenteric ischemia by computed tomography. A laparotomy was performed, showing an 80 cm segment of small bowel ischemia, and resection was done. She died one day after as a result from a septic shock refractory to treatment. The presented case was related to oral intake of S. brasiliensis, a plant containing pyrrolidine alkaloids, which are one of the main causes of HSOS in the East, highlighting the risk of liver injury with herbs intake.application/pdfengAnnals of hepatology. México. Vol. 20 (2021), 100138, 4 p.Hepatopatia veno-oclusivaRelatos de casosHipertensão portalSenecio brasiliensisSinusoidal obstruction syndromeHSOSPortal hypertensionSinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis : a case reportEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001130148.pdf.txt001130148.pdf.txtExtracted Texttext/plain23373http://www.lume.ufrgs.br/bitstream/10183/229331/2/001130148.pdf.txt3362ab630d894ac79b6919b95ce14a38MD52ORIGINAL001130148.pdfTexto completo (inglês)application/pdf1055997http://www.lume.ufrgs.br/bitstream/10183/229331/1/001130148.pdf6ae35027b0831fc36064c7ec1d1cfb71MD5110183/2293312021-09-19 04:33:49.12368oai:www.lume.ufrgs.br:10183/229331Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-09-19T07:33:49Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis : a case report |
title |
Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis : a case report |
spellingShingle |
Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis : a case report Barcelos, Samantha Thifani Alrutz Hepatopatia veno-oclusiva Relatos de casos Hipertensão portal Senecio brasiliensis Sinusoidal obstruction syndrome HSOS Portal hypertension |
title_short |
Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis : a case report |
title_full |
Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis : a case report |
title_fullStr |
Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis : a case report |
title_full_unstemmed |
Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis : a case report |
title_sort |
Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis : a case report |
author |
Barcelos, Samantha Thifani Alrutz |
author_facet |
Barcelos, Samantha Thifani Alrutz Dall’Oglio, Vincent Marin Araujo, Alexandre de Cerski, Carlos Thadeu Schmidt Álvares-da-Silva, Mário Reis |
author_role |
author |
author2 |
Dall’Oglio, Vincent Marin Araujo, Alexandre de Cerski, Carlos Thadeu Schmidt Álvares-da-Silva, Mário Reis |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Barcelos, Samantha Thifani Alrutz Dall’Oglio, Vincent Marin Araujo, Alexandre de Cerski, Carlos Thadeu Schmidt Álvares-da-Silva, Mário Reis |
dc.subject.por.fl_str_mv |
Hepatopatia veno-oclusiva Relatos de casos Hipertensão portal |
topic |
Hepatopatia veno-oclusiva Relatos de casos Hipertensão portal Senecio brasiliensis Sinusoidal obstruction syndrome HSOS Portal hypertension |
dc.subject.eng.fl_str_mv |
Senecio brasiliensis Sinusoidal obstruction syndrome HSOS Portal hypertension |
description |
Hepatic sinusoidal obstruction syndrome (HSOS) is a hepatic vascular disease histologically characterized by edema, necrosis, detachment of endothelial cells in small sinusoidal hepatic and interlobular veins and intrahepatic congestion, which leads to portal hypertension and liver dysfunction. In the Western world, most HSOS cases are associated with myeloablative pretreatment in a hematopoietic stem cell transplantation setting. Here we report a case of a 54 years old female patient, otherwise healthy, with no history of alcoholic ingestion, who presented with jaundice and signs of portal hypertension, including ascites and bilateral pleural effusion. She had no history of liver disease and denied any other risk factor for liver injury, except Senecio brasiliensis ingestion as a tea, prescribed as a therapy for menopause. Acute viral hepatitis and thrombosis of the portal system were excluded in complementary investigation, as well as sepsis, metastatic malignancy and other liver diseases, setting a RUCAM score of 6. Computed tomography demonstrated a diffuse liver parenchymal heterogeneity (in mosaic) and an extensive portosystemic collateral venous circulation, in the absence of any noticeable venous obstruction. HSOS diagnosis was confirmed through a liver biopsy. During the following-up period, patient developed refractory pleural effusion, requiring hemodialysis. Right before starting anticoagulation, she presented with abdominal pain and distention, with findings compatible of mesenteric ischemia by computed tomography. A laparotomy was performed, showing an 80 cm segment of small bowel ischemia, and resection was done. She died one day after as a result from a septic shock refractory to treatment. The presented case was related to oral intake of S. brasiliensis, a plant containing pyrrolidine alkaloids, which are one of the main causes of HSOS in the East, highlighting the risk of liver injury with herbs intake. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-09-01T04:26:37Z |
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2021 |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/229331 |
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1665-2681 |
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001130148 |
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http://hdl.handle.net/10183/229331 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Annals of hepatology. México. Vol. 20 (2021), 100138, 4 p. |
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openAccess |
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