Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? : a mini review
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/164587 |
Resumo: | Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments. |
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Ribas, Aícha Daniela Ribas eSpolti, PiérriDel Ponte, Emerson MedeirosDonato, Katarzyna Joanna ZawadaSchrekker, Henri StephanFuentefria, Alexandre Meneghello2017-08-01T02:34:55Z20161517-8382http://hdl.handle.net/10183/164587001016286Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments.application/pdfengBrazilian journal of microbiology. Vol. 47, n. 4 (out./dez. 2016), p. 793-799FarmáciaFungicidasCross-resistanceEmerging fungaç áthogensFungicide sensitivityagriculturemedicineIs the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? : a mini reviewinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001016286.pdf001016286.pdfTexto completo (inglês)application/pdf1384915http://www.lume.ufrgs.br/bitstream/10183/164587/1/001016286.pdf30e6145f152ea50d46f128571b43a29aMD51TEXT001016286.pdf.txt001016286.pdf.txtExtracted Texttext/plain40563http://www.lume.ufrgs.br/bitstream/10183/164587/2/001016286.pdf.txtcaf07a3d0bfef3584ea6b289bc6ca114MD52THUMBNAIL001016286.pdf.jpg001016286.pdf.jpgGenerated Thumbnailimage/jpeg1924http://www.lume.ufrgs.br/bitstream/10183/164587/3/001016286.pdf.jpg9ef19a5f7a2a87e919d8c33fd561be11MD5310183/1645872018-10-17 08:44:50.389oai:www.lume.ufrgs.br:10183/164587Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-17T11:44:50Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? : a mini review |
title |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? : a mini review |
spellingShingle |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? : a mini review Ribas, Aícha Daniela Ribas e Farmácia Fungicidas Cross-resistance Emerging fungaç áthogens Fungicide sensitivity agriculture medicine |
title_short |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? : a mini review |
title_full |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? : a mini review |
title_fullStr |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? : a mini review |
title_full_unstemmed |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? : a mini review |
title_sort |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? : a mini review |
author |
Ribas, Aícha Daniela Ribas e |
author_facet |
Ribas, Aícha Daniela Ribas e Spolti, Piérri Del Ponte, Emerson Medeiros Donato, Katarzyna Joanna Zawada Schrekker, Henri Stephan Fuentefria, Alexandre Meneghello |
author_role |
author |
author2 |
Spolti, Piérri Del Ponte, Emerson Medeiros Donato, Katarzyna Joanna Zawada Schrekker, Henri Stephan Fuentefria, Alexandre Meneghello |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ribas, Aícha Daniela Ribas e Spolti, Piérri Del Ponte, Emerson Medeiros Donato, Katarzyna Joanna Zawada Schrekker, Henri Stephan Fuentefria, Alexandre Meneghello |
dc.subject.por.fl_str_mv |
Farmácia Fungicidas |
topic |
Farmácia Fungicidas Cross-resistance Emerging fungaç áthogens Fungicide sensitivity agriculture medicine |
dc.subject.eng.fl_str_mv |
Cross-resistance Emerging fungaç áthogens Fungicide sensitivity agriculture medicine |
description |
Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-08-01T02:34:55Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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publishedVersion |
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http://hdl.handle.net/10183/164587 |
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1517-8382 |
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001016286 |
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1517-8382 001016286 |
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http://hdl.handle.net/10183/164587 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of microbiology. Vol. 47, n. 4 (out./dez. 2016), p. 793-799 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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