Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/216218 |
Resumo: | Background Global variation in human papillomavirus (HPV) prevalence and persistence may be explained by differences in risk factors, such as sexual activity, oral contraceptive use, and behavioral factors. We evaluated determinants of acquisition and clearance of HPV infection among young women previously unexposed to HPV. Methods Five hundred thirty-four women aged 15 to 25 years who were cytology and HPV DNA negative, and seronegative for anti-HPV-16/18 antibodies, were recruited (July 2000–September 2001) from study centers in Brazil, the United States, and Canada (NCT00689741/NCT00120848). They were followed up for 76 months. Cervical samples were HPV genotyped via polymerase chain reaction. We used multivariable (forward stepwise, P = 0.15) Cox proportional hazards regression to estimate rate ratios (RR) and 95% confidence intervals (CI), separately according to length of follow-up time. Results On short-term follow-up (0–27 months), 257 (48%; 8535.80 person-months; incidence rate = 30.11; 95% CI, 26.64–34.02) incident HPV infections were detected. Marital status, lifetime number of sex partners, history of any sexually transmitted disease, and occasional use of oral contraceptives were strongly associated with acquisition of any HPV. Having 2 or more lifetime sex partners (RR, 2.03; 95% CI, 1.37–3.02) and a history of any sexually transmitted disease (RR, 1.98; 95% CI, 1.19–3.29) were the most important determinants of high-risk HPV (hrHPV) incidence. During the entire follow-up (0–76 months), an increased hrHPV clearance was found among women in North America (RR, 1.38; 95% CI, 1.08–1.78) and black women (RR, 1.64; 95% CI, 1.04–2.60). Greater number of lifetime partners was associated with reduced clearance rates for any HPV (RR, 0.65; 95% CI, 0.43–0.98). Conclusions We identified variation in risk of HPV acquisition and clearance among women unexposed to HPV at baseline. |
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El-Zein, MariamtRamanakumar, Agnihotram V.Naud, Paulo Sergio VieroMartins, Cecilia M. RotelliCarvalho, Newton S. deBorba, Paola Colares deTeixeira, Júlio CésarMoscicki, A. B.Harper, Diane M.Tyring, Stephen K.Ramjattan, BrianDubin, GaryFranco, Eduardo Luis FabianoHPV-007 Study Group2020-12-09T04:11:50Z20190148-5717http://hdl.handle.net/10183/216218001119615Background Global variation in human papillomavirus (HPV) prevalence and persistence may be explained by differences in risk factors, such as sexual activity, oral contraceptive use, and behavioral factors. We evaluated determinants of acquisition and clearance of HPV infection among young women previously unexposed to HPV. Methods Five hundred thirty-four women aged 15 to 25 years who were cytology and HPV DNA negative, and seronegative for anti-HPV-16/18 antibodies, were recruited (July 2000–September 2001) from study centers in Brazil, the United States, and Canada (NCT00689741/NCT00120848). They were followed up for 76 months. Cervical samples were HPV genotyped via polymerase chain reaction. We used multivariable (forward stepwise, P = 0.15) Cox proportional hazards regression to estimate rate ratios (RR) and 95% confidence intervals (CI), separately according to length of follow-up time. Results On short-term follow-up (0–27 months), 257 (48%; 8535.80 person-months; incidence rate = 30.11; 95% CI, 26.64–34.02) incident HPV infections were detected. Marital status, lifetime number of sex partners, history of any sexually transmitted disease, and occasional use of oral contraceptives were strongly associated with acquisition of any HPV. Having 2 or more lifetime sex partners (RR, 2.03; 95% CI, 1.37–3.02) and a history of any sexually transmitted disease (RR, 1.98; 95% CI, 1.19–3.29) were the most important determinants of high-risk HPV (hrHPV) incidence. During the entire follow-up (0–76 months), an increased hrHPV clearance was found among women in North America (RR, 1.38; 95% CI, 1.08–1.78) and black women (RR, 1.64; 95% CI, 1.04–2.60). Greater number of lifetime partners was associated with reduced clearance rates for any HPV (RR, 0.65; 95% CI, 0.43–0.98). Conclusions We identified variation in risk of HPV acquisition and clearance among women unexposed to HPV at baseline.application/pdfengSexually transmitted diseases. Philadelphia. Vol. 46, no. 10 (2019), p. 663-669Infecções por papillomavirusFatores de riscoAdulto jovemMulheresDeterminants of acquisition and clearance of human papillomavirus infection in previously unexposed young womenEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001119615.pdf.txt001119615.pdf.txtExtracted Texttext/plain43232http://www.lume.ufrgs.br/bitstream/10183/216218/2/001119615.pdf.txtd4e3706dae43f23cc5c443095f60965aMD52ORIGINAL001119615.pdfTexto completo (inglês)application/pdf291284http://www.lume.ufrgs.br/bitstream/10183/216218/1/001119615.pdf6b887361b0bb4c9bef432244b0207ef6MD5110183/2162182020-12-10 05:10:58.64623oai:www.lume.ufrgs.br:10183/216218Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-12-10T07:10:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women |
title |
Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women |
spellingShingle |
Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women El-Zein, Mariamt Infecções por papillomavirus Fatores de risco Adulto jovem Mulheres |
title_short |
Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women |
title_full |
Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women |
title_fullStr |
Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women |
title_full_unstemmed |
Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women |
title_sort |
Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women |
author |
El-Zein, Mariamt |
author_facet |
El-Zein, Mariamt Ramanakumar, Agnihotram V. Naud, Paulo Sergio Viero Martins, Cecilia M. Rotelli Carvalho, Newton S. de Borba, Paola Colares de Teixeira, Júlio César Moscicki, A. B. Harper, Diane M. Tyring, Stephen K. Ramjattan, Brian Dubin, Gary Franco, Eduardo Luis Fabiano HPV-007 Study Group |
author_role |
author |
author2 |
Ramanakumar, Agnihotram V. Naud, Paulo Sergio Viero Martins, Cecilia M. Rotelli Carvalho, Newton S. de Borba, Paola Colares de Teixeira, Júlio César Moscicki, A. B. Harper, Diane M. Tyring, Stephen K. Ramjattan, Brian Dubin, Gary Franco, Eduardo Luis Fabiano HPV-007 Study Group |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
El-Zein, Mariamt Ramanakumar, Agnihotram V. Naud, Paulo Sergio Viero Martins, Cecilia M. Rotelli Carvalho, Newton S. de Borba, Paola Colares de Teixeira, Júlio César Moscicki, A. B. Harper, Diane M. Tyring, Stephen K. Ramjattan, Brian Dubin, Gary Franco, Eduardo Luis Fabiano HPV-007 Study Group |
dc.subject.por.fl_str_mv |
Infecções por papillomavirus Fatores de risco Adulto jovem Mulheres |
topic |
Infecções por papillomavirus Fatores de risco Adulto jovem Mulheres |
description |
Background Global variation in human papillomavirus (HPV) prevalence and persistence may be explained by differences in risk factors, such as sexual activity, oral contraceptive use, and behavioral factors. We evaluated determinants of acquisition and clearance of HPV infection among young women previously unexposed to HPV. Methods Five hundred thirty-four women aged 15 to 25 years who were cytology and HPV DNA negative, and seronegative for anti-HPV-16/18 antibodies, were recruited (July 2000–September 2001) from study centers in Brazil, the United States, and Canada (NCT00689741/NCT00120848). They were followed up for 76 months. Cervical samples were HPV genotyped via polymerase chain reaction. We used multivariable (forward stepwise, P = 0.15) Cox proportional hazards regression to estimate rate ratios (RR) and 95% confidence intervals (CI), separately according to length of follow-up time. Results On short-term follow-up (0–27 months), 257 (48%; 8535.80 person-months; incidence rate = 30.11; 95% CI, 26.64–34.02) incident HPV infections were detected. Marital status, lifetime number of sex partners, history of any sexually transmitted disease, and occasional use of oral contraceptives were strongly associated with acquisition of any HPV. Having 2 or more lifetime sex partners (RR, 2.03; 95% CI, 1.37–3.02) and a history of any sexually transmitted disease (RR, 1.98; 95% CI, 1.19–3.29) were the most important determinants of high-risk HPV (hrHPV) incidence. During the entire follow-up (0–76 months), an increased hrHPV clearance was found among women in North America (RR, 1.38; 95% CI, 1.08–1.78) and black women (RR, 1.64; 95% CI, 1.04–2.60). Greater number of lifetime partners was associated with reduced clearance rates for any HPV (RR, 0.65; 95% CI, 0.43–0.98). Conclusions We identified variation in risk of HPV acquisition and clearance among women unexposed to HPV at baseline. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2020-12-09T04:11:50Z |
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Estrangeiro info:eu-repo/semantics/article |
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Sexually transmitted diseases. Philadelphia. Vol. 46, no. 10 (2019), p. 663-669 |
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