Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women

Detalhes bibliográficos
Autor(a) principal: El-Zein, Mariamt
Data de Publicação: 2019
Outros Autores: Ramanakumar, Agnihotram V., Naud, Paulo Sergio Viero, Martins, Cecilia M. Rotelli, Carvalho, Newton S. de, Borba, Paola Colares de, Teixeira, Júlio César, Moscicki, A. B., Harper, Diane M., Tyring, Stephen K., Ramjattan, Brian, Dubin, Gary, Franco, Eduardo Luis Fabiano, HPV-007 Study Group
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/216218
Resumo: Background Global variation in human papillomavirus (HPV) prevalence and persistence may be explained by differences in risk factors, such as sexual activity, oral contraceptive use, and behavioral factors. We evaluated determinants of acquisition and clearance of HPV infection among young women previously unexposed to HPV. Methods Five hundred thirty-four women aged 15 to 25 years who were cytology and HPV DNA negative, and seronegative for anti-HPV-16/18 antibodies, were recruited (July 2000–September 2001) from study centers in Brazil, the United States, and Canada (NCT00689741/NCT00120848). They were followed up for 76 months. Cervical samples were HPV genotyped via polymerase chain reaction. We used multivariable (forward stepwise, P = 0.15) Cox proportional hazards regression to estimate rate ratios (RR) and 95% confidence intervals (CI), separately according to length of follow-up time. Results On short-term follow-up (0–27 months), 257 (48%; 8535.80 person-months; incidence rate = 30.11; 95% CI, 26.64–34.02) incident HPV infections were detected. Marital status, lifetime number of sex partners, history of any sexually transmitted disease, and occasional use of oral contraceptives were strongly associated with acquisition of any HPV. Having 2 or more lifetime sex partners (RR, 2.03; 95% CI, 1.37–3.02) and a history of any sexually transmitted disease (RR, 1.98; 95% CI, 1.19–3.29) were the most important determinants of high-risk HPV (hrHPV) incidence. During the entire follow-up (0–76 months), an increased hrHPV clearance was found among women in North America (RR, 1.38; 95% CI, 1.08–1.78) and black women (RR, 1.64; 95% CI, 1.04–2.60). Greater number of lifetime partners was associated with reduced clearance rates for any HPV (RR, 0.65; 95% CI, 0.43–0.98). Conclusions We identified variation in risk of HPV acquisition and clearance among women unexposed to HPV at baseline.
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spelling El-Zein, MariamtRamanakumar, Agnihotram V.Naud, Paulo Sergio VieroMartins, Cecilia M. RotelliCarvalho, Newton S. deBorba, Paola Colares deTeixeira, Júlio CésarMoscicki, A. B.Harper, Diane M.Tyring, Stephen K.Ramjattan, BrianDubin, GaryFranco, Eduardo Luis FabianoHPV-007 Study Group2020-12-09T04:11:50Z20190148-5717http://hdl.handle.net/10183/216218001119615Background Global variation in human papillomavirus (HPV) prevalence and persistence may be explained by differences in risk factors, such as sexual activity, oral contraceptive use, and behavioral factors. We evaluated determinants of acquisition and clearance of HPV infection among young women previously unexposed to HPV. Methods Five hundred thirty-four women aged 15 to 25 years who were cytology and HPV DNA negative, and seronegative for anti-HPV-16/18 antibodies, were recruited (July 2000–September 2001) from study centers in Brazil, the United States, and Canada (NCT00689741/NCT00120848). They were followed up for 76 months. Cervical samples were HPV genotyped via polymerase chain reaction. We used multivariable (forward stepwise, P = 0.15) Cox proportional hazards regression to estimate rate ratios (RR) and 95% confidence intervals (CI), separately according to length of follow-up time. Results On short-term follow-up (0–27 months), 257 (48%; 8535.80 person-months; incidence rate = 30.11; 95% CI, 26.64–34.02) incident HPV infections were detected. Marital status, lifetime number of sex partners, history of any sexually transmitted disease, and occasional use of oral contraceptives were strongly associated with acquisition of any HPV. Having 2 or more lifetime sex partners (RR, 2.03; 95% CI, 1.37–3.02) and a history of any sexually transmitted disease (RR, 1.98; 95% CI, 1.19–3.29) were the most important determinants of high-risk HPV (hrHPV) incidence. During the entire follow-up (0–76 months), an increased hrHPV clearance was found among women in North America (RR, 1.38; 95% CI, 1.08–1.78) and black women (RR, 1.64; 95% CI, 1.04–2.60). Greater number of lifetime partners was associated with reduced clearance rates for any HPV (RR, 0.65; 95% CI, 0.43–0.98). Conclusions We identified variation in risk of HPV acquisition and clearance among women unexposed to HPV at baseline.application/pdfengSexually transmitted diseases. Philadelphia. Vol. 46, no. 10 (2019), p. 663-669Infecções por papillomavirusFatores de riscoAdulto jovemMulheresDeterminants of acquisition and clearance of human papillomavirus infection in previously unexposed young womenEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001119615.pdf.txt001119615.pdf.txtExtracted Texttext/plain43232http://www.lume.ufrgs.br/bitstream/10183/216218/2/001119615.pdf.txtd4e3706dae43f23cc5c443095f60965aMD52ORIGINAL001119615.pdfTexto completo (inglês)application/pdf291284http://www.lume.ufrgs.br/bitstream/10183/216218/1/001119615.pdf6b887361b0bb4c9bef432244b0207ef6MD5110183/2162182020-12-10 05:10:58.64623oai:www.lume.ufrgs.br:10183/216218Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-12-10T07:10:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women
title Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women
spellingShingle Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women
El-Zein, Mariamt
Infecções por papillomavirus
Fatores de risco
Adulto jovem
Mulheres
title_short Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women
title_full Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women
title_fullStr Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women
title_full_unstemmed Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women
title_sort Determinants of acquisition and clearance of human papillomavirus infection in previously unexposed young women
author El-Zein, Mariamt
author_facet El-Zein, Mariamt
Ramanakumar, Agnihotram V.
Naud, Paulo Sergio Viero
Martins, Cecilia M. Rotelli
Carvalho, Newton S. de
Borba, Paola Colares de
Teixeira, Júlio César
Moscicki, A. B.
Harper, Diane M.
Tyring, Stephen K.
Ramjattan, Brian
Dubin, Gary
Franco, Eduardo Luis Fabiano
HPV-007 Study Group
author_role author
author2 Ramanakumar, Agnihotram V.
Naud, Paulo Sergio Viero
Martins, Cecilia M. Rotelli
Carvalho, Newton S. de
Borba, Paola Colares de
Teixeira, Júlio César
Moscicki, A. B.
Harper, Diane M.
Tyring, Stephen K.
Ramjattan, Brian
Dubin, Gary
Franco, Eduardo Luis Fabiano
HPV-007 Study Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv El-Zein, Mariamt
Ramanakumar, Agnihotram V.
Naud, Paulo Sergio Viero
Martins, Cecilia M. Rotelli
Carvalho, Newton S. de
Borba, Paola Colares de
Teixeira, Júlio César
Moscicki, A. B.
Harper, Diane M.
Tyring, Stephen K.
Ramjattan, Brian
Dubin, Gary
Franco, Eduardo Luis Fabiano
HPV-007 Study Group
dc.subject.por.fl_str_mv Infecções por papillomavirus
Fatores de risco
Adulto jovem
Mulheres
topic Infecções por papillomavirus
Fatores de risco
Adulto jovem
Mulheres
description Background Global variation in human papillomavirus (HPV) prevalence and persistence may be explained by differences in risk factors, such as sexual activity, oral contraceptive use, and behavioral factors. We evaluated determinants of acquisition and clearance of HPV infection among young women previously unexposed to HPV. Methods Five hundred thirty-four women aged 15 to 25 years who were cytology and HPV DNA negative, and seronegative for anti-HPV-16/18 antibodies, were recruited (July 2000–September 2001) from study centers in Brazil, the United States, and Canada (NCT00689741/NCT00120848). They were followed up for 76 months. Cervical samples were HPV genotyped via polymerase chain reaction. We used multivariable (forward stepwise, P = 0.15) Cox proportional hazards regression to estimate rate ratios (RR) and 95% confidence intervals (CI), separately according to length of follow-up time. Results On short-term follow-up (0–27 months), 257 (48%; 8535.80 person-months; incidence rate = 30.11; 95% CI, 26.64–34.02) incident HPV infections were detected. Marital status, lifetime number of sex partners, history of any sexually transmitted disease, and occasional use of oral contraceptives were strongly associated with acquisition of any HPV. Having 2 or more lifetime sex partners (RR, 2.03; 95% CI, 1.37–3.02) and a history of any sexually transmitted disease (RR, 1.98; 95% CI, 1.19–3.29) were the most important determinants of high-risk HPV (hrHPV) incidence. During the entire follow-up (0–76 months), an increased hrHPV clearance was found among women in North America (RR, 1.38; 95% CI, 1.08–1.78) and black women (RR, 1.64; 95% CI, 1.04–2.60). Greater number of lifetime partners was associated with reduced clearance rates for any HPV (RR, 0.65; 95% CI, 0.43–0.98). Conclusions We identified variation in risk of HPV acquisition and clearance among women unexposed to HPV at baseline.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-12-09T04:11:50Z
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Sexually transmitted diseases. Philadelphia. Vol. 46, no. 10 (2019), p. 663-669
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