Descending control of nociceptive processing in knee osteoarthritis is associated with intracortical disinhibition : an exploratory study

• Autor(a) principal: Tarragó, Maria da Graça Lopes
• Data de Publicação: 2016
• Outros Autores: Deitos, Alícia, Brietzke, Aline Patrícia, Vercelino, Rafael, Torres, Iraci Lucena da Silva, Fregni, Felipe, Caumo, Wolnei
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/187817
• topic: Dor crônica; Osteoartrite do joelho; Tratos piramidais

Based on the hypothesis that an imbalance in excitatory and inhibitory input is a central mechanism of knee osteoarthritis chronic pain (KOACP), this exploratory study had the following aims: to compare whether the function of the descending inhibitory pain pathway is associated with the state of inhibition in the corticospinal system indexed by the motor-evoked potential (MEP) and the cortical salient period (CSP) in patients with severe osteoarthritis (OA) and healthy controls; and to determine if there is correlation between the measures of intracortical inhibition (CSP, MEP) with changes on the numerical pain scale (NPS [0–10]) in KOACP during a conditioned pain modulation (CPM)-task considering the effect of self-reported function assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and analgesic use.