Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease

Detalhes bibliográficos
Autor(a) principal: Bertoluci, Marcello Casaccia
Data de Publicação: 2010
Outros Autores: Quadros, Alexandre Schaan de, Sarmento Leite, Rogerio, Schaan, Beatriz D'Agord
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/24205
Resumo: Background: Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. Aims: To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. Methods: In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Results: Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG/HDLc = 8.5 and [HOMA-IR×TG/HDLc] = 28. Positive predictive value for coronary artery disease for HOMA-IR>6.0 was 82.6%, for TG/HDLc>8.5 was 85.7% and for [HOMA-IR×TG/HDLc]>28 was 88.0%. Adjusted relative risk (age, gender, diabetes, body mass index, systolic blood pressure) for the presence of coronary artery disease was: for HOMA-IR>6.0, 1.47 (95.CI: 1.06-2.04, p = 0.027), for TG/HDLc>8.5, 1.46 (95% CI:1.07-1.98), p = 0.015) and for [HOMA-IR × TG/HDLc] >28, 1.64 (95%CI: 1.28-2.09), p < 0.001). Conclusions: Increased HOMA-IR, TG/HDLc and their product are positively associated with angiographic coronary artery disease, and may be useful for risk stratification as a high-specificity test for coronary artery disease.
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spelling Bertoluci, Marcello CasacciaQuadros, Alexandre Schaan deSarmento Leite, RogerioSchaan, Beatriz D'Agord2010-07-01T04:18:40Z2010http://hdl.handle.net/10183/24205000746362Background: Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. Aims: To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. Methods: In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Results: Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG/HDLc = 8.5 and [HOMA-IR×TG/HDLc] = 28. Positive predictive value for coronary artery disease for HOMA-IR>6.0 was 82.6%, for TG/HDLc>8.5 was 85.7% and for [HOMA-IR×TG/HDLc]>28 was 88.0%. Adjusted relative risk (age, gender, diabetes, body mass index, systolic blood pressure) for the presence of coronary artery disease was: for HOMA-IR>6.0, 1.47 (95.CI: 1.06-2.04, p = 0.027), for TG/HDLc>8.5, 1.46 (95% CI:1.07-1.98), p = 0.015) and for [HOMA-IR × TG/HDLc] >28, 1.64 (95%CI: 1.28-2.09), p < 0.001). Conclusions: Increased HOMA-IR, TG/HDLc and their product are positively associated with angiographic coronary artery disease, and may be useful for risk stratification as a high-specificity test for coronary artery disease.application/pdfengDiabetology & metabolic syndrome. [Rio de Janeiro]. Vol. 2, no. 11 (2010), 5 p.Resistência à insulinaDoença da artéria coronarianaTriglicerídeosHDL-colesterolInsulin resistance and triglyceride/HDLc index are associated with coronary artery diseaseinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000746362.pdf000746362.pdfTexto completo (inglês)application/pdf282304http://www.lume.ufrgs.br/bitstream/10183/24205/1/000746362.pdf9a2fa3805ce4997c55e97101638d3e48MD51TEXT000746362.pdf.txt000746362.pdf.txtExtracted Texttext/plain22406http://www.lume.ufrgs.br/bitstream/10183/24205/2/000746362.pdf.txt7c0fdaf6b865d2baf00ff57efaeec1faMD52THUMBNAIL000746362.pdf.jpg000746362.pdf.jpgGenerated Thumbnailimage/jpeg2063http://www.lume.ufrgs.br/bitstream/10183/24205/3/000746362.pdf.jpg0aaff887416acba5605f9b5dbb099791MD5310183/242052024-01-06 04:36:00.262571oai:www.lume.ufrgs.br:10183/24205Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2024-01-06T06:36Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease
title Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease
spellingShingle Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease
Bertoluci, Marcello Casaccia
Resistência à insulina
Doença da artéria coronariana
Triglicerídeos
HDL-colesterol
title_short Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease
title_full Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease
title_fullStr Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease
title_full_unstemmed Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease
title_sort Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease
author Bertoluci, Marcello Casaccia
author_facet Bertoluci, Marcello Casaccia
Quadros, Alexandre Schaan de
Sarmento Leite, Rogerio
Schaan, Beatriz D'Agord
author_role author
author2 Quadros, Alexandre Schaan de
Sarmento Leite, Rogerio
Schaan, Beatriz D'Agord
author2_role author
author
author
dc.contributor.author.fl_str_mv Bertoluci, Marcello Casaccia
Quadros, Alexandre Schaan de
Sarmento Leite, Rogerio
Schaan, Beatriz D'Agord
dc.subject.por.fl_str_mv Resistência à insulina
Doença da artéria coronariana
Triglicerídeos
HDL-colesterol
topic Resistência à insulina
Doença da artéria coronariana
Triglicerídeos
HDL-colesterol
description Background: Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. Aims: To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. Methods: In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Results: Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG/HDLc = 8.5 and [HOMA-IR×TG/HDLc] = 28. Positive predictive value for coronary artery disease for HOMA-IR>6.0 was 82.6%, for TG/HDLc>8.5 was 85.7% and for [HOMA-IR×TG/HDLc]>28 was 88.0%. Adjusted relative risk (age, gender, diabetes, body mass index, systolic blood pressure) for the presence of coronary artery disease was: for HOMA-IR>6.0, 1.47 (95.CI: 1.06-2.04, p = 0.027), for TG/HDLc>8.5, 1.46 (95% CI:1.07-1.98), p = 0.015) and for [HOMA-IR × TG/HDLc] >28, 1.64 (95%CI: 1.28-2.09), p < 0.001). Conclusions: Increased HOMA-IR, TG/HDLc and their product are positively associated with angiographic coronary artery disease, and may be useful for risk stratification as a high-specificity test for coronary artery disease.
publishDate 2010
dc.date.accessioned.fl_str_mv 2010-07-01T04:18:40Z
dc.date.issued.fl_str_mv 2010
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dc.relation.ispartof.pt_BR.fl_str_mv Diabetology & metabolic syndrome. [Rio de Janeiro]. Vol. 2, no. 11 (2010), 5 p.
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