Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis

Detalhes bibliográficos
Autor(a) principal: Cheinquer, Nelson
Data de Publicação: 2010
Outros Autores: Cheinquer, Hugo, Wolff, Fernando Herz, Coelho-Borges, Silvia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/37822
Resumo: Background and objectives: Evidence suggests that sustained virologic response to interferon treatment decreases incidence of hepatocellular carcinoma in patients with hepatitis C virus cirrhosis. This study was designed to compare the incidence of hepatocellular carcinoma among cirrhotic patients exposed to interferon based treatment with or without achieving a sustained virological response, in order to evaluate the role of interferon itself in the prevention hepatocellular carcinoma. Methods: A cohort of 85 patients with compensated hepatitis C cirrhosis was followed after treatment with interferon and ribavirin. Sustained virological response was defi ned as negative polymerase chain reaction assay 24 weeks after the end of treatment. Patients were followed every 6 months with ultrasound and alpha-fetoprotein. Hepatocellular carcinoma was diagnosed by the fi nding of a focal liver lesion greater than 2 cm with arterial hypervascularization on two imaging techniques and/or by liver biopsy. Results: The mean follow-up time was 32.1 ± 20 months for patients who achieved a sustained virological response and 28.2 ± 18 months among 47 patients (55%) without SVR. Hepatocellular carcinoma was diagnosed in 1 (3%) vs. 8 (17%) responders and non responders respectively (p = 0.02). Conclusion: Patients with cirrhosis due to hepatitis C virus who achieved sustained virological response had signifi cantly lower incidence of hepatocellular carcinoma when compared to those without treatment response. Interferon treatment without achieving sustained virological response does not seem to protect against hepatocellular carcinoma.
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spelling Cheinquer, NelsonCheinquer, HugoWolff, Fernando HerzCoelho-Borges, Silvia2012-03-23T01:20:56Z20101413-8670http://hdl.handle.net/10183/37822000778485Background and objectives: Evidence suggests that sustained virologic response to interferon treatment decreases incidence of hepatocellular carcinoma in patients with hepatitis C virus cirrhosis. This study was designed to compare the incidence of hepatocellular carcinoma among cirrhotic patients exposed to interferon based treatment with or without achieving a sustained virological response, in order to evaluate the role of interferon itself in the prevention hepatocellular carcinoma. Methods: A cohort of 85 patients with compensated hepatitis C cirrhosis was followed after treatment with interferon and ribavirin. Sustained virological response was defi ned as negative polymerase chain reaction assay 24 weeks after the end of treatment. Patients were followed every 6 months with ultrasound and alpha-fetoprotein. Hepatocellular carcinoma was diagnosed by the fi nding of a focal liver lesion greater than 2 cm with arterial hypervascularization on two imaging techniques and/or by liver biopsy. Results: The mean follow-up time was 32.1 ± 20 months for patients who achieved a sustained virological response and 28.2 ± 18 months among 47 patients (55%) without SVR. Hepatocellular carcinoma was diagnosed in 1 (3%) vs. 8 (17%) responders and non responders respectively (p = 0.02). Conclusion: Patients with cirrhosis due to hepatitis C virus who achieved sustained virological response had signifi cantly lower incidence of hepatocellular carcinoma when compared to those without treatment response. Interferon treatment without achieving sustained virological response does not seem to protect against hepatocellular carcinoma.application/pdfengThe Brazilian journal of infectious diseases. Vol. 14, n. 5 (set./out. 2010), p. 457-461Carcinoma hepatocelularCirrose hepáticaHepatite CHepatocellular carcinomaHCV interferonSustained virologic responseCirrhosisEffect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000778485.pdf000778485.pdfTexto completo (inglês)application/pdf1003280http://www.lume.ufrgs.br/bitstream/10183/37822/1/000778485.pdf149147c8c737335006978ef1f1fc69e1MD51TEXT000778485.pdf.txt000778485.pdf.txtExtracted Texttext/plain23222http://www.lume.ufrgs.br/bitstream/10183/37822/2/000778485.pdf.txtef38ed53704d4e85c82fb4ec679e9595MD52THUMBNAIL000778485.pdf.jpg000778485.pdf.jpgGenerated Thumbnailimage/jpeg1896http://www.lume.ufrgs.br/bitstream/10183/37822/3/000778485.pdf.jpg50ae4c9f6291a34b259f7d0735437b35MD5310183/378222023-06-15 03:28:28.593149oai:www.lume.ufrgs.br:10183/37822Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-06-15T06:28:28Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis
title Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis
spellingShingle Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis
Cheinquer, Nelson
Carcinoma hepatocelular
Cirrose hepática
Hepatite C
Hepatocellular carcinoma
HCV interferon
Sustained virologic response
Cirrhosis
title_short Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis
title_full Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis
title_fullStr Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis
title_full_unstemmed Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis
title_sort Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis
author Cheinquer, Nelson
author_facet Cheinquer, Nelson
Cheinquer, Hugo
Wolff, Fernando Herz
Coelho-Borges, Silvia
author_role author
author2 Cheinquer, Hugo
Wolff, Fernando Herz
Coelho-Borges, Silvia
author2_role author
author
author
dc.contributor.author.fl_str_mv Cheinquer, Nelson
Cheinquer, Hugo
Wolff, Fernando Herz
Coelho-Borges, Silvia
dc.subject.por.fl_str_mv Carcinoma hepatocelular
Cirrose hepática
Hepatite C
topic Carcinoma hepatocelular
Cirrose hepática
Hepatite C
Hepatocellular carcinoma
HCV interferon
Sustained virologic response
Cirrhosis
dc.subject.eng.fl_str_mv Hepatocellular carcinoma
HCV interferon
Sustained virologic response
Cirrhosis
description Background and objectives: Evidence suggests that sustained virologic response to interferon treatment decreases incidence of hepatocellular carcinoma in patients with hepatitis C virus cirrhosis. This study was designed to compare the incidence of hepatocellular carcinoma among cirrhotic patients exposed to interferon based treatment with or without achieving a sustained virological response, in order to evaluate the role of interferon itself in the prevention hepatocellular carcinoma. Methods: A cohort of 85 patients with compensated hepatitis C cirrhosis was followed after treatment with interferon and ribavirin. Sustained virological response was defi ned as negative polymerase chain reaction assay 24 weeks after the end of treatment. Patients were followed every 6 months with ultrasound and alpha-fetoprotein. Hepatocellular carcinoma was diagnosed by the fi nding of a focal liver lesion greater than 2 cm with arterial hypervascularization on two imaging techniques and/or by liver biopsy. Results: The mean follow-up time was 32.1 ± 20 months for patients who achieved a sustained virological response and 28.2 ± 18 months among 47 patients (55%) without SVR. Hepatocellular carcinoma was diagnosed in 1 (3%) vs. 8 (17%) responders and non responders respectively (p = 0.02). Conclusion: Patients with cirrhosis due to hepatitis C virus who achieved sustained virological response had signifi cantly lower incidence of hepatocellular carcinoma when compared to those without treatment response. Interferon treatment without achieving sustained virological response does not seem to protect against hepatocellular carcinoma.
publishDate 2010
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dc.relation.ispartof.pt_BR.fl_str_mv The Brazilian journal of infectious diseases. Vol. 14, n. 5 (set./out. 2010), p. 457-461
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