Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/37822 |
Resumo: | Background and objectives: Evidence suggests that sustained virologic response to interferon treatment decreases incidence of hepatocellular carcinoma in patients with hepatitis C virus cirrhosis. This study was designed to compare the incidence of hepatocellular carcinoma among cirrhotic patients exposed to interferon based treatment with or without achieving a sustained virological response, in order to evaluate the role of interferon itself in the prevention hepatocellular carcinoma. Methods: A cohort of 85 patients with compensated hepatitis C cirrhosis was followed after treatment with interferon and ribavirin. Sustained virological response was defi ned as negative polymerase chain reaction assay 24 weeks after the end of treatment. Patients were followed every 6 months with ultrasound and alpha-fetoprotein. Hepatocellular carcinoma was diagnosed by the fi nding of a focal liver lesion greater than 2 cm with arterial hypervascularization on two imaging techniques and/or by liver biopsy. Results: The mean follow-up time was 32.1 ± 20 months for patients who achieved a sustained virological response and 28.2 ± 18 months among 47 patients (55%) without SVR. Hepatocellular carcinoma was diagnosed in 1 (3%) vs. 8 (17%) responders and non responders respectively (p = 0.02). Conclusion: Patients with cirrhosis due to hepatitis C virus who achieved sustained virological response had signifi cantly lower incidence of hepatocellular carcinoma when compared to those without treatment response. Interferon treatment without achieving sustained virological response does not seem to protect against hepatocellular carcinoma. |
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Cheinquer, NelsonCheinquer, HugoWolff, Fernando HerzCoelho-Borges, Silvia2012-03-23T01:20:56Z20101413-8670http://hdl.handle.net/10183/37822000778485Background and objectives: Evidence suggests that sustained virologic response to interferon treatment decreases incidence of hepatocellular carcinoma in patients with hepatitis C virus cirrhosis. This study was designed to compare the incidence of hepatocellular carcinoma among cirrhotic patients exposed to interferon based treatment with or without achieving a sustained virological response, in order to evaluate the role of interferon itself in the prevention hepatocellular carcinoma. Methods: A cohort of 85 patients with compensated hepatitis C cirrhosis was followed after treatment with interferon and ribavirin. Sustained virological response was defi ned as negative polymerase chain reaction assay 24 weeks after the end of treatment. Patients were followed every 6 months with ultrasound and alpha-fetoprotein. Hepatocellular carcinoma was diagnosed by the fi nding of a focal liver lesion greater than 2 cm with arterial hypervascularization on two imaging techniques and/or by liver biopsy. Results: The mean follow-up time was 32.1 ± 20 months for patients who achieved a sustained virological response and 28.2 ± 18 months among 47 patients (55%) without SVR. Hepatocellular carcinoma was diagnosed in 1 (3%) vs. 8 (17%) responders and non responders respectively (p = 0.02). Conclusion: Patients with cirrhosis due to hepatitis C virus who achieved sustained virological response had signifi cantly lower incidence of hepatocellular carcinoma when compared to those without treatment response. Interferon treatment without achieving sustained virological response does not seem to protect against hepatocellular carcinoma.application/pdfengThe Brazilian journal of infectious diseases. Vol. 14, n. 5 (set./out. 2010), p. 457-461Carcinoma hepatocelularCirrose hepáticaHepatite CHepatocellular carcinomaHCV interferonSustained virologic responseCirrhosisEffect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000778485.pdf000778485.pdfTexto completo (inglês)application/pdf1003280http://www.lume.ufrgs.br/bitstream/10183/37822/1/000778485.pdf149147c8c737335006978ef1f1fc69e1MD51TEXT000778485.pdf.txt000778485.pdf.txtExtracted Texttext/plain23222http://www.lume.ufrgs.br/bitstream/10183/37822/2/000778485.pdf.txtef38ed53704d4e85c82fb4ec679e9595MD52THUMBNAIL000778485.pdf.jpg000778485.pdf.jpgGenerated Thumbnailimage/jpeg1896http://www.lume.ufrgs.br/bitstream/10183/37822/3/000778485.pdf.jpg50ae4c9f6291a34b259f7d0735437b35MD5310183/378222023-06-15 03:28:28.593149oai:www.lume.ufrgs.br:10183/37822Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-06-15T06:28:28Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis |
title |
Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis |
spellingShingle |
Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis Cheinquer, Nelson Carcinoma hepatocelular Cirrose hepática Hepatite C Hepatocellular carcinoma HCV interferon Sustained virologic response Cirrhosis |
title_short |
Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis |
title_full |
Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis |
title_fullStr |
Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis |
title_full_unstemmed |
Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis |
title_sort |
Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis |
author |
Cheinquer, Nelson |
author_facet |
Cheinquer, Nelson Cheinquer, Hugo Wolff, Fernando Herz Coelho-Borges, Silvia |
author_role |
author |
author2 |
Cheinquer, Hugo Wolff, Fernando Herz Coelho-Borges, Silvia |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Cheinquer, Nelson Cheinquer, Hugo Wolff, Fernando Herz Coelho-Borges, Silvia |
dc.subject.por.fl_str_mv |
Carcinoma hepatocelular Cirrose hepática Hepatite C |
topic |
Carcinoma hepatocelular Cirrose hepática Hepatite C Hepatocellular carcinoma HCV interferon Sustained virologic response Cirrhosis |
dc.subject.eng.fl_str_mv |
Hepatocellular carcinoma HCV interferon Sustained virologic response Cirrhosis |
description |
Background and objectives: Evidence suggests that sustained virologic response to interferon treatment decreases incidence of hepatocellular carcinoma in patients with hepatitis C virus cirrhosis. This study was designed to compare the incidence of hepatocellular carcinoma among cirrhotic patients exposed to interferon based treatment with or without achieving a sustained virological response, in order to evaluate the role of interferon itself in the prevention hepatocellular carcinoma. Methods: A cohort of 85 patients with compensated hepatitis C cirrhosis was followed after treatment with interferon and ribavirin. Sustained virological response was defi ned as negative polymerase chain reaction assay 24 weeks after the end of treatment. Patients were followed every 6 months with ultrasound and alpha-fetoprotein. Hepatocellular carcinoma was diagnosed by the fi nding of a focal liver lesion greater than 2 cm with arterial hypervascularization on two imaging techniques and/or by liver biopsy. Results: The mean follow-up time was 32.1 ± 20 months for patients who achieved a sustained virological response and 28.2 ± 18 months among 47 patients (55%) without SVR. Hepatocellular carcinoma was diagnosed in 1 (3%) vs. 8 (17%) responders and non responders respectively (p = 0.02). Conclusion: Patients with cirrhosis due to hepatitis C virus who achieved sustained virological response had signifi cantly lower incidence of hepatocellular carcinoma when compared to those without treatment response. Interferon treatment without achieving sustained virological response does not seem to protect against hepatocellular carcinoma. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2012-03-23T01:20:56Z |
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eng |
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The Brazilian journal of infectious diseases. Vol. 14, n. 5 (set./out. 2010), p. 457-461 |
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