Long-term outcomes with agalsidase alfa enzyme replacement therapy : analysis using deconstructed composite events

Detalhes bibliográficos
Autor(a) principal: Beck, Michael
Data de Publicação: 2017
Outros Autores: Hughes, Derralynn A., Kampmann, Christoph, Pintos-Morell, G., Ramaswami, Uma, West, Michael L., Giugliani, Roberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/196083
Resumo: This is a retrospective analysis of Fabry Outcome Survey data from children/adults (n =677) receiving agalsidase alfa enzyme replacement therapy for a median of 3 years, examining cerebrovascular, cardiac, and renal morbidity endpoints separately. Cardiac events occurred at younger ages than cerebrovascular or renal events, cerebrovascular events were more frequent in females than males, and males were more likely to experience cardiac and renal events at a younger age than females.
id UFRGS-2_8ab65c90be4ae2050039705e6cf22d84
oai_identifier_str oai:www.lume.ufrgs.br:10183/196083
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Beck, MichaelHughes, Derralynn A.Kampmann, ChristophPintos-Morell, G.Ramaswami, UmaWest, Michael L.Giugliani, Roberto2019-06-22T02:35:01Z20172214-4269http://hdl.handle.net/10183/196083001089836This is a retrospective analysis of Fabry Outcome Survey data from children/adults (n =677) receiving agalsidase alfa enzyme replacement therapy for a median of 3 years, examining cerebrovascular, cardiac, and renal morbidity endpoints separately. Cardiac events occurred at younger ages than cerebrovascular or renal events, cerebrovascular events were more frequent in females than males, and males were more likely to experience cardiac and renal events at a younger age than females.application/pdfengMolecular genetics and metabolism reports. Amsterdam. vol. 14 (Mar. 2018), p. 31-35Terapia de reposição de enzimasDoença de FabryFabry diseaseEnzyme replacement therapyAgalsidase alfaLong-term effectivenessLong-term outcomes with agalsidase alfa enzyme replacement therapy : analysis using deconstructed composite eventsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001089836.pdf.txt001089836.pdf.txtExtracted Texttext/plain23290http://www.lume.ufrgs.br/bitstream/10183/196083/2/001089836.pdf.txt53ac2bf910f185e921549cd5814d9e94MD52ORIGINAL001089836.pdfTexto completo (inglês)application/pdf252286http://www.lume.ufrgs.br/bitstream/10183/196083/1/001089836.pdfb6c0ea3b71424f89f84fc45cc0ed4578MD5110183/1960832019-06-23 02:33:52.333036oai:www.lume.ufrgs.br:10183/196083Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-06-23T05:33:52Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Long-term outcomes with agalsidase alfa enzyme replacement therapy : analysis using deconstructed composite events
title Long-term outcomes with agalsidase alfa enzyme replacement therapy : analysis using deconstructed composite events
spellingShingle Long-term outcomes with agalsidase alfa enzyme replacement therapy : analysis using deconstructed composite events
Beck, Michael
Terapia de reposição de enzimas
Doença de Fabry
Fabry disease
Enzyme replacement therapy
Agalsidase alfa
Long-term effectiveness
title_short Long-term outcomes with agalsidase alfa enzyme replacement therapy : analysis using deconstructed composite events
title_full Long-term outcomes with agalsidase alfa enzyme replacement therapy : analysis using deconstructed composite events
title_fullStr Long-term outcomes with agalsidase alfa enzyme replacement therapy : analysis using deconstructed composite events
title_full_unstemmed Long-term outcomes with agalsidase alfa enzyme replacement therapy : analysis using deconstructed composite events
title_sort Long-term outcomes with agalsidase alfa enzyme replacement therapy : analysis using deconstructed composite events
author Beck, Michael
author_facet Beck, Michael
Hughes, Derralynn A.
Kampmann, Christoph
Pintos-Morell, G.
Ramaswami, Uma
West, Michael L.
Giugliani, Roberto
author_role author
author2 Hughes, Derralynn A.
Kampmann, Christoph
Pintos-Morell, G.
Ramaswami, Uma
West, Michael L.
Giugliani, Roberto
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Beck, Michael
Hughes, Derralynn A.
Kampmann, Christoph
Pintos-Morell, G.
Ramaswami, Uma
West, Michael L.
Giugliani, Roberto
dc.subject.por.fl_str_mv Terapia de reposição de enzimas
Doença de Fabry
topic Terapia de reposição de enzimas
Doença de Fabry
Fabry disease
Enzyme replacement therapy
Agalsidase alfa
Long-term effectiveness
dc.subject.eng.fl_str_mv Fabry disease
Enzyme replacement therapy
Agalsidase alfa
Long-term effectiveness
description This is a retrospective analysis of Fabry Outcome Survey data from children/adults (n =677) receiving agalsidase alfa enzyme replacement therapy for a median of 3 years, examining cerebrovascular, cardiac, and renal morbidity endpoints separately. Cardiac events occurred at younger ages than cerebrovascular or renal events, cerebrovascular events were more frequent in females than males, and males were more likely to experience cardiac and renal events at a younger age than females.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-06-22T02:35:01Z
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/196083
dc.identifier.issn.pt_BR.fl_str_mv 2214-4269
dc.identifier.nrb.pt_BR.fl_str_mv 001089836
identifier_str_mv 2214-4269
001089836
url http://hdl.handle.net/10183/196083
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Molecular genetics and metabolism reports. Amsterdam. vol. 14 (Mar. 2018), p. 31-35
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/196083/2/001089836.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/196083/1/001089836.pdf
bitstream.checksum.fl_str_mv 53ac2bf910f185e921549cd5814d9e94
b6c0ea3b71424f89f84fc45cc0ed4578
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv
_version_ 1801224969221308416

Registros relacionados