Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation

Detalhes bibliográficos
Autor(a) principal: Silva, Nadia Regina Jardim da
Data de Publicação: 2015
Outros Autores: Laste, Gabriela, Deitos, Alícia, Stefani, Luciana Paula Cadore, Canto, Gustavo Cambraia do, Torres, Iraci Lucena da Silva, Brunoni, Andre Russowsky, Fregni, Felipe, Caumo, Wolnei
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/187803
Resumo: Transcranial direct current stimulation (tDCS) and melatonin can effectively treat pain. Given their potentially complementary mechanisms of action, their combination could have a synergistic effect. Thus, we tested the hypothesis that compared to the control condition and melatonin alone, tDCS combined with melatonin would have a greater effect on pain modulatory effect, as assessed by quantitative sensory testing (QST) and by the pain level during the Conditioned Pain Modulation (CPM)-task. Furthermore, the combined treatment would have a greater cortical excitability effect as indicated by the transcranial magnetic stimulation (TMS) and on the serum BDNF level. Healthy males (n = 20), (aged 18–40 years), in a blinded, placebo-controlled, crossover, clinical trial, were randomized into three groups: sublingual melatonin (0.25 mg/kg) + a-tDCS, melatonin (0.25 mg/kg) + sham-(s)-tDCS, or sublingual placebo+sham-(s)- tDCS. Anodal stimulation (2 mA, 20 min) was applied over the primary motor cortex. There was a significant difference in the heat pain threshold ( C) for melatonin+a-tDCS vs. placebo+s-tDCS (mean difference: 4.86, 95% confidence interval [CI]: 0.9 to 8.63) and melatonin+s-tDCS vs. placebo+s-tDCS (mean: 5.16, 95% CI: 0.84 to 8.36). There was no difference between melatonin+s-tDCS and melatonin+a-tDCS (mean difference: 0.29, 95% CI: 3.72 to 4.23). The mean change from the baseline on amplitude of motor evocate potential (MEP) was significantly higher in the melatonin+a-tDCS (19.96% 5.2) compared with melatonin+s-tDCS group (1.36% 5.35) and with placebo+s-tDCS group (3.61% 10.48), respectively (p < 0.05 for both comparisons). While melatonin alone or combined with a-tDCS did not significantly affect CPM task result, and serum BDNF level. The melatonin effectively reduced pain; however, its association with a-tDCS did not present an additional modulatory effect on acute induced pain.
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spelling Silva, Nadia Regina Jardim daLaste, GabrielaDeitos, AlíciaStefani, Luciana Paula CadoreCanto, Gustavo Cambraia doTorres, Iraci Lucena da SilvaBrunoni, Andre RussowskyFregni, FelipeCaumo, Wolnei2019-01-16T04:09:52Z20151662-5153http://hdl.handle.net/10183/187803000956682Transcranial direct current stimulation (tDCS) and melatonin can effectively treat pain. Given their potentially complementary mechanisms of action, their combination could have a synergistic effect. Thus, we tested the hypothesis that compared to the control condition and melatonin alone, tDCS combined with melatonin would have a greater effect on pain modulatory effect, as assessed by quantitative sensory testing (QST) and by the pain level during the Conditioned Pain Modulation (CPM)-task. Furthermore, the combined treatment would have a greater cortical excitability effect as indicated by the transcranial magnetic stimulation (TMS) and on the serum BDNF level. Healthy males (n = 20), (aged 18–40 years), in a blinded, placebo-controlled, crossover, clinical trial, were randomized into three groups: sublingual melatonin (0.25 mg/kg) + a-tDCS, melatonin (0.25 mg/kg) + sham-(s)-tDCS, or sublingual placebo+sham-(s)- tDCS. Anodal stimulation (2 mA, 20 min) was applied over the primary motor cortex. There was a significant difference in the heat pain threshold ( C) for melatonin+a-tDCS vs. placebo+s-tDCS (mean difference: 4.86, 95% confidence interval [CI]: 0.9 to 8.63) and melatonin+s-tDCS vs. placebo+s-tDCS (mean: 5.16, 95% CI: 0.84 to 8.36). There was no difference between melatonin+s-tDCS and melatonin+a-tDCS (mean difference: 0.29, 95% CI: 3.72 to 4.23). The mean change from the baseline on amplitude of motor evocate potential (MEP) was significantly higher in the melatonin+a-tDCS (19.96% 5.2) compared with melatonin+s-tDCS group (1.36% 5.35) and with placebo+s-tDCS group (3.61% 10.48), respectively (p < 0.05 for both comparisons). While melatonin alone or combined with a-tDCS did not significantly affect CPM task result, and serum BDNF level. The melatonin effectively reduced pain; however, its association with a-tDCS did not present an additional modulatory effect on acute induced pain.application/pdfengFrontiers in behavioral neuroscience. Lausanne. Vol. 9 (Mar. 2015), article 77, [12] p.Estimulação magnética transcranianaLimiar da dorMelatoninaEnsaio clínicotDCSTMSCPMPain thresholdMelatoninClinical trialCombined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulationEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000956682.pdf.txt000956682.pdf.txtExtracted Texttext/plain75390http://www.lume.ufrgs.br/bitstream/10183/187803/2/000956682.pdf.txtb060409ddb0eef068fcf3f5d7e245884MD52ORIGINAL000956682.pdfTexto completo (inglês)application/pdf634777http://www.lume.ufrgs.br/bitstream/10183/187803/1/000956682.pdff1fcb571e1f44c63d1344fbf53bc12e2MD5110183/1878032019-01-17 04:23:19.102515oai:www.lume.ufrgs.br:10183/187803Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-01-17T06:23:19Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation
title Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation
spellingShingle Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation
Silva, Nadia Regina Jardim da
Estimulação magnética transcraniana
Limiar da dor
Melatonina
Ensaio clínico
tDCS
TMS
CPM
Pain threshold
Melatonin
Clinical trial
title_short Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation
title_full Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation
title_fullStr Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation
title_full_unstemmed Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation
title_sort Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation
author Silva, Nadia Regina Jardim da
author_facet Silva, Nadia Regina Jardim da
Laste, Gabriela
Deitos, Alícia
Stefani, Luciana Paula Cadore
Canto, Gustavo Cambraia do
Torres, Iraci Lucena da Silva
Brunoni, Andre Russowsky
Fregni, Felipe
Caumo, Wolnei
author_role author
author2 Laste, Gabriela
Deitos, Alícia
Stefani, Luciana Paula Cadore
Canto, Gustavo Cambraia do
Torres, Iraci Lucena da Silva
Brunoni, Andre Russowsky
Fregni, Felipe
Caumo, Wolnei
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Nadia Regina Jardim da
Laste, Gabriela
Deitos, Alícia
Stefani, Luciana Paula Cadore
Canto, Gustavo Cambraia do
Torres, Iraci Lucena da Silva
Brunoni, Andre Russowsky
Fregni, Felipe
Caumo, Wolnei
dc.subject.por.fl_str_mv Estimulação magnética transcraniana
Limiar da dor
Melatonina
Ensaio clínico
topic Estimulação magnética transcraniana
Limiar da dor
Melatonina
Ensaio clínico
tDCS
TMS
CPM
Pain threshold
Melatonin
Clinical trial
dc.subject.eng.fl_str_mv tDCS
TMS
CPM
Pain threshold
Melatonin
Clinical trial
description Transcranial direct current stimulation (tDCS) and melatonin can effectively treat pain. Given their potentially complementary mechanisms of action, their combination could have a synergistic effect. Thus, we tested the hypothesis that compared to the control condition and melatonin alone, tDCS combined with melatonin would have a greater effect on pain modulatory effect, as assessed by quantitative sensory testing (QST) and by the pain level during the Conditioned Pain Modulation (CPM)-task. Furthermore, the combined treatment would have a greater cortical excitability effect as indicated by the transcranial magnetic stimulation (TMS) and on the serum BDNF level. Healthy males (n = 20), (aged 18–40 years), in a blinded, placebo-controlled, crossover, clinical trial, were randomized into three groups: sublingual melatonin (0.25 mg/kg) + a-tDCS, melatonin (0.25 mg/kg) + sham-(s)-tDCS, or sublingual placebo+sham-(s)- tDCS. Anodal stimulation (2 mA, 20 min) was applied over the primary motor cortex. There was a significant difference in the heat pain threshold ( C) for melatonin+a-tDCS vs. placebo+s-tDCS (mean difference: 4.86, 95% confidence interval [CI]: 0.9 to 8.63) and melatonin+s-tDCS vs. placebo+s-tDCS (mean: 5.16, 95% CI: 0.84 to 8.36). There was no difference between melatonin+s-tDCS and melatonin+a-tDCS (mean difference: 0.29, 95% CI: 3.72 to 4.23). The mean change from the baseline on amplitude of motor evocate potential (MEP) was significantly higher in the melatonin+a-tDCS (19.96% 5.2) compared with melatonin+s-tDCS group (1.36% 5.35) and with placebo+s-tDCS group (3.61% 10.48), respectively (p < 0.05 for both comparisons). While melatonin alone or combined with a-tDCS did not significantly affect CPM task result, and serum BDNF level. The melatonin effectively reduced pain; however, its association with a-tDCS did not present an additional modulatory effect on acute induced pain.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-01-16T04:09:52Z
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dc.relation.ispartof.pt_BR.fl_str_mv Frontiers in behavioral neuroscience. Lausanne. Vol. 9 (Mar. 2015), article 77, [12] p.
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