Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/187803 |
Resumo: | Transcranial direct current stimulation (tDCS) and melatonin can effectively treat pain. Given their potentially complementary mechanisms of action, their combination could have a synergistic effect. Thus, we tested the hypothesis that compared to the control condition and melatonin alone, tDCS combined with melatonin would have a greater effect on pain modulatory effect, as assessed by quantitative sensory testing (QST) and by the pain level during the Conditioned Pain Modulation (CPM)-task. Furthermore, the combined treatment would have a greater cortical excitability effect as indicated by the transcranial magnetic stimulation (TMS) and on the serum BDNF level. Healthy males (n = 20), (aged 18–40 years), in a blinded, placebo-controlled, crossover, clinical trial, were randomized into three groups: sublingual melatonin (0.25 mg/kg) + a-tDCS, melatonin (0.25 mg/kg) + sham-(s)-tDCS, or sublingual placebo+sham-(s)- tDCS. Anodal stimulation (2 mA, 20 min) was applied over the primary motor cortex. There was a significant difference in the heat pain threshold ( C) for melatonin+a-tDCS vs. placebo+s-tDCS (mean difference: 4.86, 95% confidence interval [CI]: 0.9 to 8.63) and melatonin+s-tDCS vs. placebo+s-tDCS (mean: 5.16, 95% CI: 0.84 to 8.36). There was no difference between melatonin+s-tDCS and melatonin+a-tDCS (mean difference: 0.29, 95% CI: 3.72 to 4.23). The mean change from the baseline on amplitude of motor evocate potential (MEP) was significantly higher in the melatonin+a-tDCS (19.96% 5.2) compared with melatonin+s-tDCS group (1.36% 5.35) and with placebo+s-tDCS group (3.61% 10.48), respectively (p < 0.05 for both comparisons). While melatonin alone or combined with a-tDCS did not significantly affect CPM task result, and serum BDNF level. The melatonin effectively reduced pain; however, its association with a-tDCS did not present an additional modulatory effect on acute induced pain. |
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Silva, Nadia Regina Jardim daLaste, GabrielaDeitos, AlíciaStefani, Luciana Paula CadoreCanto, Gustavo Cambraia doTorres, Iraci Lucena da SilvaBrunoni, Andre RussowskyFregni, FelipeCaumo, Wolnei2019-01-16T04:09:52Z20151662-5153http://hdl.handle.net/10183/187803000956682Transcranial direct current stimulation (tDCS) and melatonin can effectively treat pain. Given their potentially complementary mechanisms of action, their combination could have a synergistic effect. Thus, we tested the hypothesis that compared to the control condition and melatonin alone, tDCS combined with melatonin would have a greater effect on pain modulatory effect, as assessed by quantitative sensory testing (QST) and by the pain level during the Conditioned Pain Modulation (CPM)-task. Furthermore, the combined treatment would have a greater cortical excitability effect as indicated by the transcranial magnetic stimulation (TMS) and on the serum BDNF level. Healthy males (n = 20), (aged 18–40 years), in a blinded, placebo-controlled, crossover, clinical trial, were randomized into three groups: sublingual melatonin (0.25 mg/kg) + a-tDCS, melatonin (0.25 mg/kg) + sham-(s)-tDCS, or sublingual placebo+sham-(s)- tDCS. Anodal stimulation (2 mA, 20 min) was applied over the primary motor cortex. There was a significant difference in the heat pain threshold ( C) for melatonin+a-tDCS vs. placebo+s-tDCS (mean difference: 4.86, 95% confidence interval [CI]: 0.9 to 8.63) and melatonin+s-tDCS vs. placebo+s-tDCS (mean: 5.16, 95% CI: 0.84 to 8.36). There was no difference between melatonin+s-tDCS and melatonin+a-tDCS (mean difference: 0.29, 95% CI: 3.72 to 4.23). The mean change from the baseline on amplitude of motor evocate potential (MEP) was significantly higher in the melatonin+a-tDCS (19.96% 5.2) compared with melatonin+s-tDCS group (1.36% 5.35) and with placebo+s-tDCS group (3.61% 10.48), respectively (p < 0.05 for both comparisons). While melatonin alone or combined with a-tDCS did not significantly affect CPM task result, and serum BDNF level. The melatonin effectively reduced pain; however, its association with a-tDCS did not present an additional modulatory effect on acute induced pain.application/pdfengFrontiers in behavioral neuroscience. Lausanne. Vol. 9 (Mar. 2015), article 77, [12] p.Estimulação magnética transcranianaLimiar da dorMelatoninaEnsaio clínicotDCSTMSCPMPain thresholdMelatoninClinical trialCombined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulationEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000956682.pdf.txt000956682.pdf.txtExtracted Texttext/plain75390http://www.lume.ufrgs.br/bitstream/10183/187803/2/000956682.pdf.txtb060409ddb0eef068fcf3f5d7e245884MD52ORIGINAL000956682.pdfTexto completo (inglês)application/pdf634777http://www.lume.ufrgs.br/bitstream/10183/187803/1/000956682.pdff1fcb571e1f44c63d1344fbf53bc12e2MD5110183/1878032019-01-17 04:23:19.102515oai:www.lume.ufrgs.br:10183/187803Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-01-17T06:23:19Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation |
title |
Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation |
spellingShingle |
Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation Silva, Nadia Regina Jardim da Estimulação magnética transcraniana Limiar da dor Melatonina Ensaio clínico tDCS TMS CPM Pain threshold Melatonin Clinical trial |
title_short |
Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation |
title_full |
Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation |
title_fullStr |
Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation |
title_full_unstemmed |
Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation |
title_sort |
Combined neuromodulatory interventions in acute experimental pain : assessment of melatonin and non-invasive brain stimulation |
author |
Silva, Nadia Regina Jardim da |
author_facet |
Silva, Nadia Regina Jardim da Laste, Gabriela Deitos, Alícia Stefani, Luciana Paula Cadore Canto, Gustavo Cambraia do Torres, Iraci Lucena da Silva Brunoni, Andre Russowsky Fregni, Felipe Caumo, Wolnei |
author_role |
author |
author2 |
Laste, Gabriela Deitos, Alícia Stefani, Luciana Paula Cadore Canto, Gustavo Cambraia do Torres, Iraci Lucena da Silva Brunoni, Andre Russowsky Fregni, Felipe Caumo, Wolnei |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Nadia Regina Jardim da Laste, Gabriela Deitos, Alícia Stefani, Luciana Paula Cadore Canto, Gustavo Cambraia do Torres, Iraci Lucena da Silva Brunoni, Andre Russowsky Fregni, Felipe Caumo, Wolnei |
dc.subject.por.fl_str_mv |
Estimulação magnética transcraniana Limiar da dor Melatonina Ensaio clínico |
topic |
Estimulação magnética transcraniana Limiar da dor Melatonina Ensaio clínico tDCS TMS CPM Pain threshold Melatonin Clinical trial |
dc.subject.eng.fl_str_mv |
tDCS TMS CPM Pain threshold Melatonin Clinical trial |
description |
Transcranial direct current stimulation (tDCS) and melatonin can effectively treat pain. Given their potentially complementary mechanisms of action, their combination could have a synergistic effect. Thus, we tested the hypothesis that compared to the control condition and melatonin alone, tDCS combined with melatonin would have a greater effect on pain modulatory effect, as assessed by quantitative sensory testing (QST) and by the pain level during the Conditioned Pain Modulation (CPM)-task. Furthermore, the combined treatment would have a greater cortical excitability effect as indicated by the transcranial magnetic stimulation (TMS) and on the serum BDNF level. Healthy males (n = 20), (aged 18–40 years), in a blinded, placebo-controlled, crossover, clinical trial, were randomized into three groups: sublingual melatonin (0.25 mg/kg) + a-tDCS, melatonin (0.25 mg/kg) + sham-(s)-tDCS, or sublingual placebo+sham-(s)- tDCS. Anodal stimulation (2 mA, 20 min) was applied over the primary motor cortex. There was a significant difference in the heat pain threshold ( C) for melatonin+a-tDCS vs. placebo+s-tDCS (mean difference: 4.86, 95% confidence interval [CI]: 0.9 to 8.63) and melatonin+s-tDCS vs. placebo+s-tDCS (mean: 5.16, 95% CI: 0.84 to 8.36). There was no difference between melatonin+s-tDCS and melatonin+a-tDCS (mean difference: 0.29, 95% CI: 3.72 to 4.23). The mean change from the baseline on amplitude of motor evocate potential (MEP) was significantly higher in the melatonin+a-tDCS (19.96% 5.2) compared with melatonin+s-tDCS group (1.36% 5.35) and with placebo+s-tDCS group (3.61% 10.48), respectively (p < 0.05 for both comparisons). While melatonin alone or combined with a-tDCS did not significantly affect CPM task result, and serum BDNF level. The melatonin effectively reduced pain; however, its association with a-tDCS did not present an additional modulatory effect on acute induced pain. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2019-01-16T04:09:52Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
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eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in behavioral neuroscience. Lausanne. Vol. 9 (Mar. 2015), article 77, [12] p. |
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