Genotoxic effect of alkaloids

Detalhes bibliográficos
Autor(a) principal: Henriques, João Antonio Pêgas
Data de Publicação: 1991
Outros Autores: Moreno, Paulo Roberto Hrihorowitsch, Von Poser, Gilsane Lino, Querol, Carmen Boto, Henriques, Amelia Teresinha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/19219
Resumo: Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotoxícity in the presence of a metabolic activation mixture. Voacristine isolated from the leaves of Ervatamia coronaria shows in vivo cytostatic and mu tagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.
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spelling Henriques, João Antonio PêgasMoreno, Paulo Roberto HrihorowitschVon Poser, Gilsane LinoQuerol, Carmen BotoHenriques, Amelia Teresinha2010-04-16T08:54:08Z19910074-0276http://hdl.handle.net/10183/19219000003844Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotoxícity in the presence of a metabolic activation mixture. Voacristine isolated from the leaves of Ervatamia coronaria shows in vivo cytostatic and mu tagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.application/pdfengMemorias do Instituto Oswaldo Cruz : an International Journal of Biological and Biomedical Research. Rio de Janeiro. Vol. 86, supl. II (1991), p. 71-74AlcalóidesSos chromotesteSaccharomyces cerevisiaeGenotoxicidadeAlkaloídsSOS-chromotestSaccharomyces cerevisiaeMutationRecombinationGenotoxic effect of alkaloidsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000003844.pdf.txt000003844.pdf.txtExtracted Texttext/plain14383http://www.lume.ufrgs.br/bitstream/10183/19219/2/000003844.pdf.txt34d67c39b9ecb9ef44d559ae749b16b6MD52ORIGINAL000003844.pdf000003844.pdfTexto completo (inglês)application/pdf256926http://www.lume.ufrgs.br/bitstream/10183/19219/1/000003844.pdf2d60b5472ae45b79f14f461bb4f7743eMD51THUMBNAIL000003844.pdf.jpg000003844.pdf.jpgGenerated Thumbnailimage/jpeg2140http://www.lume.ufrgs.br/bitstream/10183/19219/3/000003844.pdf.jpg615b226930d16dec512c1e828cf7491cMD5310183/192192019-06-20 02:35:39.459199oai:www.lume.ufrgs.br:10183/19219Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-06-20T05:35:39Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Genotoxic effect of alkaloids
title Genotoxic effect of alkaloids
spellingShingle Genotoxic effect of alkaloids
Henriques, João Antonio Pêgas
Alcalóides
Sos chromoteste
Saccharomyces cerevisiae
Genotoxicidade
Alkaloíds
SOS-chromotest
Saccharomyces cerevisiae
Mutation
Recombination
title_short Genotoxic effect of alkaloids
title_full Genotoxic effect of alkaloids
title_fullStr Genotoxic effect of alkaloids
title_full_unstemmed Genotoxic effect of alkaloids
title_sort Genotoxic effect of alkaloids
author Henriques, João Antonio Pêgas
author_facet Henriques, João Antonio Pêgas
Moreno, Paulo Roberto Hrihorowitsch
Von Poser, Gilsane Lino
Querol, Carmen Boto
Henriques, Amelia Teresinha
author_role author
author2 Moreno, Paulo Roberto Hrihorowitsch
Von Poser, Gilsane Lino
Querol, Carmen Boto
Henriques, Amelia Teresinha
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Henriques, João Antonio Pêgas
Moreno, Paulo Roberto Hrihorowitsch
Von Poser, Gilsane Lino
Querol, Carmen Boto
Henriques, Amelia Teresinha
dc.subject.por.fl_str_mv Alcalóides
Sos chromoteste
Saccharomyces cerevisiae
Genotoxicidade
topic Alcalóides
Sos chromoteste
Saccharomyces cerevisiae
Genotoxicidade
Alkaloíds
SOS-chromotest
Saccharomyces cerevisiae
Mutation
Recombination
dc.subject.eng.fl_str_mv Alkaloíds
SOS-chromotest
Saccharomyces cerevisiae
Mutation
Recombination
description Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotoxícity in the presence of a metabolic activation mixture. Voacristine isolated from the leaves of Ervatamia coronaria shows in vivo cytostatic and mu tagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.
publishDate 1991
dc.date.issued.fl_str_mv 1991
dc.date.accessioned.fl_str_mv 2010-04-16T08:54:08Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/19219
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Memorias do Instituto Oswaldo Cruz : an International Journal of Biological and Biomedical Research. Rio de Janeiro. Vol. 86, supl. II (1991), p. 71-74
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