Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/220774 |
Resumo: | Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role. |
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Torres Avila, Jose FernandoEspitia-Pérez, LydaBonatto, DiegoSilva, Fernanda Rabaioli daOliveira, Iuri Marques deSilva, Luis Felipe OliveiraCorrea, Dione SilvaDias, Johnny FerrazSilva, Juliana daHenriques, João Antonio Pêgas2021-05-13T04:25:18Z20201415-4757http://hdl.handle.net/10183/220774001122583Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role.application/pdfengGenetics and molecular biology. Ribeirão Preto. Vol. 43, n. 3 (2020), e20190134, 20 p.Dano ao DNACarvãoExposição ambientalCiclo celularCoalColombiaCell cycleSystems chemo-biologySystems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposureinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001122583.pdf.txt001122583.pdf.txtExtracted Texttext/plain75007http://www.lume.ufrgs.br/bitstream/10183/220774/2/001122583.pdf.txtd7a6f8efae765bf4eacd64b3b21c6a50MD52ORIGINAL001122583.pdfTexto completo (inglês)application/pdf9064554http://www.lume.ufrgs.br/bitstream/10183/220774/1/001122583.pdf17096620b5ca32d80afc2f9929149d63MD5110183/2207742024-05-01 06:51:00.554082oai:www.lume.ufrgs.br:10183/220774Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-05-01T09:51Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
title |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
spellingShingle |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure Torres Avila, Jose Fernando Dano ao DNA Carvão Exposição ambiental Ciclo celular Coal Colombia Cell cycle Systems chemo-biology |
title_short |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
title_full |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
title_fullStr |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
title_full_unstemmed |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
title_sort |
Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure |
author |
Torres Avila, Jose Fernando |
author_facet |
Torres Avila, Jose Fernando Espitia-Pérez, Lyda Bonatto, Diego Silva, Fernanda Rabaioli da Oliveira, Iuri Marques de Silva, Luis Felipe Oliveira Correa, Dione Silva Dias, Johnny Ferraz Silva, Juliana da Henriques, João Antonio Pêgas |
author_role |
author |
author2 |
Espitia-Pérez, Lyda Bonatto, Diego Silva, Fernanda Rabaioli da Oliveira, Iuri Marques de Silva, Luis Felipe Oliveira Correa, Dione Silva Dias, Johnny Ferraz Silva, Juliana da Henriques, João Antonio Pêgas |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Torres Avila, Jose Fernando Espitia-Pérez, Lyda Bonatto, Diego Silva, Fernanda Rabaioli da Oliveira, Iuri Marques de Silva, Luis Felipe Oliveira Correa, Dione Silva Dias, Johnny Ferraz Silva, Juliana da Henriques, João Antonio Pêgas |
dc.subject.por.fl_str_mv |
Dano ao DNA Carvão Exposição ambiental Ciclo celular |
topic |
Dano ao DNA Carvão Exposição ambiental Ciclo celular Coal Colombia Cell cycle Systems chemo-biology |
dc.subject.eng.fl_str_mv |
Coal Colombia Cell cycle Systems chemo-biology |
description |
Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and proteins associated with the cell cycle. Our results highlight the role of oxidative stress generated by the exposure to the residues of coal extraction, such as major inorganic oxides (MIOs), inorganic elements (IEs) and polycyclic aromatic hydrocarbons (PAH) on DNA damage and alterations in the progression of the cell cycle (blockage and/or delay), as well as structural dysfunction in several proteins. In particular, IEs such as Cr, Ni, and S and PAHs such as benzo[a]pyrene may have influential roles in the regulation of the cell cycle through DNA damage and oxidative stress. In this process, cyclins, cyclin-dependent kinases, zinc finger proteins such as TP53, and protein kinases may play a central role. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-05-13T04:25:18Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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http://hdl.handle.net/10183/220774 |
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1415-4757 |
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001122583 |
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http://hdl.handle.net/10183/220774 |
dc.language.iso.fl_str_mv |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Genetics and molecular biology. Ribeirão Preto. Vol. 43, n. 3 (2020), e20190134, 20 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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