Increased of the carotid intima media thickness in preeclampsia

• Autor(a) principal: Moreira Neto, Raul
• Data de Publicação: 2020
• Outros Autores: Ramos, José Geraldo Lopes, Medjedovic, Edin, Begic, Edin
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/225148
• topic: Pré-eclâmpsia; Gravidez; Mulheres; Espessura intima-media carotídea; Biomarcadores; Prognóstico; Preeclampsia; Pregnancy; Screening

Objectives: The aim of the study was to determine carotid intima-media thickness (CIMT) values in patients who developed and did not develop preeclampsia (PE), and to determine whether CIMT values could be predictors of PE development. Methods: The study included pregnant women who were examined by regular ultrasound examination at the Materno-Infantil Presidente Vargas Hospital (HMIPV) in Porto Alegre, Brazil, from April 2016 to September 2017. The examinations were performed every three months. Patients were divided into two groups. The first group included patients diagnosed with PE (n=21) and second group included patients who did not have PE (n=199). A high frequency ultrasound device (12 MHz) with a semiautomatic method was used to estimate CIMT. Results: CIMT was significantly higher in pregnant women with PE than in women without PE (55±0.11 vs. 0.44±0.06, respectively; p<0.001). Using a cut-off value of 0.51 mm, CIMT had a specificity of 77.9% and sensitivity of 81% in the diagnosis of PE. With CIMT ≥0.6 mm, the probability of a patient developing PE was 44.4%; with CIMT >0.42 mm, the probability was only 4.2%. Conclusions: An increase in CIMT was associated with the onset of PE. CIMT values were significantly higher in patients who develop PE.