Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21218 |
Resumo: | Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor agonists (CP-94,253 and CP-93,129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 μg/0.2 μL, N = 8, and 1.0 μg/0.2 μL, N = 8) or CP-93,129 (1.0 μg/0.2 μL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was recorded for 10 min. The frequency and duration of aggressive and non-aggressive behaviors were analyzed using ANOVA and post hoc tests. CP-93,129 significantly decreased maternal aggression. The frequency of lateral attacks, bites and pinnings was reduced compared to control, while the non-aggressive behaviors and maternal care were largely unaffected by this treatment. CP-94,253 had no significant effects on aggressive or non-aggressive behaviors when microinjected into the same area of female rats. CP-93,129, a specific 5-HT1B receptor agonist, administered into the VO PFC reduced maternal aggressive behavior, while the CP-94,253 agonist did not significantly affect this behavior after social instigation in female rats. We conclude that only the 5-HT1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation. |
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Veiga, Caroline Perinazzo daMiczek, Klaus AlexanderLucion, Aldo BoltenAlmeida, Rosa Maria Martins de2010-04-24T04:15:48Z20070100-879Xhttp://hdl.handle.net/10183/21218000648266Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor agonists (CP-94,253 and CP-93,129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 μg/0.2 μL, N = 8, and 1.0 μg/0.2 μL, N = 8) or CP-93,129 (1.0 μg/0.2 μL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was recorded for 10 min. The frequency and duration of aggressive and non-aggressive behaviors were analyzed using ANOVA and post hoc tests. CP-93,129 significantly decreased maternal aggression. The frequency of lateral attacks, bites and pinnings was reduced compared to control, while the non-aggressive behaviors and maternal care were largely unaffected by this treatment. CP-94,253 had no significant effects on aggressive or non-aggressive behaviors when microinjected into the same area of female rats. CP-93,129, a specific 5-HT1B receptor agonist, administered into the VO PFC reduced maternal aggressive behavior, while the CP-94,253 agonist did not significantly affect this behavior after social instigation in female rats. We conclude that only the 5-HT1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 40, no. 6 (June 2007), p. 825-830Serotonina : Comportamento : Agressividade : RatasReceptores de serotoninaPrefrontal cortex5-HT receptorsSerotoninMaternal behaviorAggressionEffect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in ratsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000648266.pdf.txt000648266.pdf.txtExtracted Texttext/plain20302http://www.lume.ufrgs.br/bitstream/10183/21218/2/000648266.pdf.txta2495b59f75fbeabecbfd3f2c8470b9dMD52ORIGINAL000648266.pdf000648266.pdfTexto completo (inglês)application/pdf501891http://www.lume.ufrgs.br/bitstream/10183/21218/1/000648266.pdf4f1d6a5057a4a94e6e385ba469176948MD51THUMBNAIL000648266.pdf.jpg000648266.pdf.jpgGenerated Thumbnailimage/jpeg1560http://www.lume.ufrgs.br/bitstream/10183/21218/3/000648266.pdf.jpgd84c1a45909074c1afd0e8d41a084d52MD5310183/212182021-11-20 05:40:46.80407oai:www.lume.ufrgs.br:10183/21218Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-11-20T07:40:46Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
title |
Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
spellingShingle |
Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats Veiga, Caroline Perinazzo da Serotonina : Comportamento : Agressividade : Ratas Receptores de serotonina Prefrontal cortex 5-HT receptors Serotonin Maternal behavior Aggression |
title_short |
Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
title_full |
Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
title_fullStr |
Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
title_full_unstemmed |
Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
title_sort |
Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
author |
Veiga, Caroline Perinazzo da |
author_facet |
Veiga, Caroline Perinazzo da Miczek, Klaus Alexander Lucion, Aldo Bolten Almeida, Rosa Maria Martins de |
author_role |
author |
author2 |
Miczek, Klaus Alexander Lucion, Aldo Bolten Almeida, Rosa Maria Martins de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Veiga, Caroline Perinazzo da Miczek, Klaus Alexander Lucion, Aldo Bolten Almeida, Rosa Maria Martins de |
dc.subject.por.fl_str_mv |
Serotonina : Comportamento : Agressividade : Ratas Receptores de serotonina |
topic |
Serotonina : Comportamento : Agressividade : Ratas Receptores de serotonina Prefrontal cortex 5-HT receptors Serotonin Maternal behavior Aggression |
dc.subject.eng.fl_str_mv |
Prefrontal cortex 5-HT receptors Serotonin Maternal behavior Aggression |
description |
Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor agonists (CP-94,253 and CP-93,129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 μg/0.2 μL, N = 8, and 1.0 μg/0.2 μL, N = 8) or CP-93,129 (1.0 μg/0.2 μL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was recorded for 10 min. The frequency and duration of aggressive and non-aggressive behaviors were analyzed using ANOVA and post hoc tests. CP-93,129 significantly decreased maternal aggression. The frequency of lateral attacks, bites and pinnings was reduced compared to control, while the non-aggressive behaviors and maternal care were largely unaffected by this treatment. CP-94,253 had no significant effects on aggressive or non-aggressive behaviors when microinjected into the same area of female rats. CP-93,129, a specific 5-HT1B receptor agonist, administered into the VO PFC reduced maternal aggressive behavior, while the CP-94,253 agonist did not significantly affect this behavior after social instigation in female rats. We conclude that only the 5-HT1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:48Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/21218 |
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0100-879X |
dc.identifier.nrb.pt_BR.fl_str_mv |
000648266 |
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http://hdl.handle.net/10183/21218 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 40, no. 6 (June 2007), p. 825-830 |
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openAccess |
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