Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/94998 |
Resumo: | The aim of this study was to investigate the effect of laser phototherapy (LPT) in the prevention and/or treatment of oral mucositis induced by 5-fluorouracil (5-FU; Eurofarma, São Paulo, Brazil) in hamsters. Ninety-six hamsters were divided into four groups (n = 24): Control (no treatment); Preventive [LPT from day (D) D−5 to D+5]; Therapeutic (LPT from D+5 to D+15); and Combined (preventive plus therapeutic LPT from D−5 to D+15). The animals received an intraperitoneal injection of 5-FU on Days 0 and 2. The pouch mucosa was scratched on Days 3 and 4. The irradiation parameters were: indium-gallium-aluminum- phosphide (InGaAlP) diode laser (MM Optics, São Carlos, Brazil) (660 nm), beam area of 0.036 cm², 40 mW, 1.11 W/cm², 6.6 J/cm², power density applied daily of 39.6 J/cm², in punctual mode (six points and six seconds per point) and contact mode, one application per day. The animals were sacrificed on Days 0, 5, 10 and 15 (n = 6) and weighed, and the pouch mucosa was removed for histopathological analysis. Clinical and corresponding histological scores were compared using ANOVA and Tukey’s test (p ≤ 0.05). Similar weight losses ranging from 5% to 10% occurred in all groups. The therapeutic group had significantly lower clinical and histological scores than the other groups at Day 10. This study showed that positive effects on oral mucositis management were obtained only when LPT was applied in the therapeutic protocol (from D+5 to D+15 after chemotherapy). |
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Lopez, Talita Christine CamiloMartins, Manoela DominguesPavesi, Vanessa Christina SantosFerreira, Leila SoaresBussadori, Sandra KalilMoreira, Maria Stella Nunes AraújoMarques, Márcia Martins2014-05-07T02:04:45Z20131806-8324http://hdl.handle.net/10183/94998000896920The aim of this study was to investigate the effect of laser phototherapy (LPT) in the prevention and/or treatment of oral mucositis induced by 5-fluorouracil (5-FU; Eurofarma, São Paulo, Brazil) in hamsters. Ninety-six hamsters were divided into four groups (n = 24): Control (no treatment); Preventive [LPT from day (D) D−5 to D+5]; Therapeutic (LPT from D+5 to D+15); and Combined (preventive plus therapeutic LPT from D−5 to D+15). The animals received an intraperitoneal injection of 5-FU on Days 0 and 2. The pouch mucosa was scratched on Days 3 and 4. The irradiation parameters were: indium-gallium-aluminum- phosphide (InGaAlP) diode laser (MM Optics, São Carlos, Brazil) (660 nm), beam area of 0.036 cm², 40 mW, 1.11 W/cm², 6.6 J/cm², power density applied daily of 39.6 J/cm², in punctual mode (six points and six seconds per point) and contact mode, one application per day. The animals were sacrificed on Days 0, 5, 10 and 15 (n = 6) and weighed, and the pouch mucosa was removed for histopathological analysis. Clinical and corresponding histological scores were compared using ANOVA and Tukey’s test (p ≤ 0.05). Similar weight losses ranging from 5% to 10% occurred in all groups. The therapeutic group had significantly lower clinical and histological scores than the other groups at Day 10. This study showed that positive effects on oral mucositis management were obtained only when LPT was applied in the therapeutic protocol (from D+5 to D+15 after chemotherapy).application/pdfengBrazilian oral research. São Paulo. Vol. 27, n. 4 (jul./ago. 2013), p. 342-348Mucosa bucal : DoencasLaser na odontologiaRadioterapiaTherapeuticsRadiotherapyLasersStomatitisEffect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamstersinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000896920.pdf000896920.pdfTexto completo (inglês)application/pdf3355248http://www.lume.ufrgs.br/bitstream/10183/94998/1/000896920.pdf970df4b5870adc9dde4fe56a9b282255MD51TEXT000896920.pdf.txt000896920.pdf.txtExtracted Texttext/plain25894http://www.lume.ufrgs.br/bitstream/10183/94998/2/000896920.pdf.txt05f4eee15c511521a1f1e7f12fe781c5MD52THUMBNAIL000896920.pdf.jpg000896920.pdf.jpgGenerated Thumbnailimage/jpeg1884http://www.lume.ufrgs.br/bitstream/10183/94998/3/000896920.pdf.jpg7022d08d2f4c48fdb6cb01805656c2ebMD5310183/949982021-07-09 04:33:56.232282oai:www.lume.ufrgs.br:10183/94998Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-07-09T07:33:56Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters |
title |
Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters |
spellingShingle |
Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters Lopez, Talita Christine Camilo Mucosa bucal : Doencas Laser na odontologia Radioterapia Therapeutics Radiotherapy Lasers Stomatitis |
title_short |
Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters |
title_full |
Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters |
title_fullStr |
Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters |
title_full_unstemmed |
Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters |
title_sort |
Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters |
author |
Lopez, Talita Christine Camilo |
author_facet |
Lopez, Talita Christine Camilo Martins, Manoela Domingues Pavesi, Vanessa Christina Santos Ferreira, Leila Soares Bussadori, Sandra Kalil Moreira, Maria Stella Nunes Araújo Marques, Márcia Martins |
author_role |
author |
author2 |
Martins, Manoela Domingues Pavesi, Vanessa Christina Santos Ferreira, Leila Soares Bussadori, Sandra Kalil Moreira, Maria Stella Nunes Araújo Marques, Márcia Martins |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Lopez, Talita Christine Camilo Martins, Manoela Domingues Pavesi, Vanessa Christina Santos Ferreira, Leila Soares Bussadori, Sandra Kalil Moreira, Maria Stella Nunes Araújo Marques, Márcia Martins |
dc.subject.por.fl_str_mv |
Mucosa bucal : Doencas Laser na odontologia Radioterapia |
topic |
Mucosa bucal : Doencas Laser na odontologia Radioterapia Therapeutics Radiotherapy Lasers Stomatitis |
dc.subject.eng.fl_str_mv |
Therapeutics Radiotherapy Lasers Stomatitis |
description |
The aim of this study was to investigate the effect of laser phototherapy (LPT) in the prevention and/or treatment of oral mucositis induced by 5-fluorouracil (5-FU; Eurofarma, São Paulo, Brazil) in hamsters. Ninety-six hamsters were divided into four groups (n = 24): Control (no treatment); Preventive [LPT from day (D) D−5 to D+5]; Therapeutic (LPT from D+5 to D+15); and Combined (preventive plus therapeutic LPT from D−5 to D+15). The animals received an intraperitoneal injection of 5-FU on Days 0 and 2. The pouch mucosa was scratched on Days 3 and 4. The irradiation parameters were: indium-gallium-aluminum- phosphide (InGaAlP) diode laser (MM Optics, São Carlos, Brazil) (660 nm), beam area of 0.036 cm², 40 mW, 1.11 W/cm², 6.6 J/cm², power density applied daily of 39.6 J/cm², in punctual mode (six points and six seconds per point) and contact mode, one application per day. The animals were sacrificed on Days 0, 5, 10 and 15 (n = 6) and weighed, and the pouch mucosa was removed for histopathological analysis. Clinical and corresponding histological scores were compared using ANOVA and Tukey’s test (p ≤ 0.05). Similar weight losses ranging from 5% to 10% occurred in all groups. The therapeutic group had significantly lower clinical and histological scores than the other groups at Day 10. This study showed that positive effects on oral mucositis management were obtained only when LPT was applied in the therapeutic protocol (from D+5 to D+15 after chemotherapy). |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2014-05-07T02:04:45Z |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/94998 |
dc.identifier.issn.pt_BR.fl_str_mv |
1806-8324 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000896920 |
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http://hdl.handle.net/10183/94998 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian oral research. São Paulo. Vol. 27, n. 4 (jul./ago. 2013), p. 342-348 |
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openAccess |
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