Divergent genetic mechanism leads to spiny hair in rodents
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/224823 |
Resumo: | Spines, or modified hairs, have evolved multiple times in mammals, particularly in rodents. In this study, we investigated the evolution of spines in six rodent families. We first measured and compared the morphology and physical properties of hairs between paired spiny and non-spiny sister lineages. We found two distinct hair morphologies had evolved repeatedly in spiny rodents: hairs with a grooved cross-section and a second near cylindrical form. Compared to the ancestral elliptical-shaped hairs, spiny hairs had higher tension and stiffness, and overall, hairs with similar morphology had similar functional properties. To examine the genetic basis of this convergent evolution, we tested whether a single amino acid change (V370A) in the Ectodysplasin A receptor (Edar) gene is associated with spiny hair, as this substitution causes thicker and straighter hair in East Asian human populations. We found that most mammals have the common amino acid valine at position 370, but two species, the kangaroo rat (non-spiny) and spiny pocket mouse (spiny), have an isoleucine. Importantly, none of the variants we identified are associated with differences in rodent hair morphology. Thus, the specific Edar mutation associated with variation in human hair does not seem to play a role in modifying hairs in wild rodents, suggesting that different mutations in Edar and/or other genes are responsible for variation in the spiny hair phenotypes we observed within rodents. |
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Gonçalves, Gislene LopesMaestri, RenanMoreira, Gilson Rudinei PiresJacobi, Marly Antonia MaldanerFreitas, Thales Renato Ochotorena deHoekstra, Hopi E.2021-07-30T04:36:46Z20181932-6203http://hdl.handle.net/10183/224823001099568Spines, or modified hairs, have evolved multiple times in mammals, particularly in rodents. In this study, we investigated the evolution of spines in six rodent families. We first measured and compared the morphology and physical properties of hairs between paired spiny and non-spiny sister lineages. We found two distinct hair morphologies had evolved repeatedly in spiny rodents: hairs with a grooved cross-section and a second near cylindrical form. Compared to the ancestral elliptical-shaped hairs, spiny hairs had higher tension and stiffness, and overall, hairs with similar morphology had similar functional properties. To examine the genetic basis of this convergent evolution, we tested whether a single amino acid change (V370A) in the Ectodysplasin A receptor (Edar) gene is associated with spiny hair, as this substitution causes thicker and straighter hair in East Asian human populations. We found that most mammals have the common amino acid valine at position 370, but two species, the kangaroo rat (non-spiny) and spiny pocket mouse (spiny), have an isoleucine. Importantly, none of the variants we identified are associated with differences in rodent hair morphology. Thus, the specific Edar mutation associated with variation in human hair does not seem to play a role in modifying hairs in wild rodents, suggesting that different mutations in Edar and/or other genes are responsible for variation in the spiny hair phenotypes we observed within rodents.application/pdfengPLoS ONE. San Francisco. Vol. 13, no. 8 (Aug. 2018), e0202219, 16 p.Ruído : Efeitos adversosCabelo espinhosoRoedoresGenéticaDivergent genetic mechanism leads to spiny hair in rodentsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001099568.pdf.txt001099568.pdf.txtExtracted Texttext/plain47067http://www.lume.ufrgs.br/bitstream/10183/224823/2/001099568.pdf.txtf8e9e45726a88ae4c658e9a51c67b4c9MD52ORIGINAL001099568.pdfTexto completo (inglês)application/pdf9476554http://www.lume.ufrgs.br/bitstream/10183/224823/1/001099568.pdfcaacd57fab3b93a7ae2cd4813db0fd4cMD5110183/2248232023-09-23 03:37:53.732741oai:www.lume.ufrgs.br:10183/224823Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-23T06:37:53Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Divergent genetic mechanism leads to spiny hair in rodents |
title |
Divergent genetic mechanism leads to spiny hair in rodents |
spellingShingle |
Divergent genetic mechanism leads to spiny hair in rodents Gonçalves, Gislene Lopes Ruído : Efeitos adversos Cabelo espinhoso Roedores Genética |
title_short |
Divergent genetic mechanism leads to spiny hair in rodents |
title_full |
Divergent genetic mechanism leads to spiny hair in rodents |
title_fullStr |
Divergent genetic mechanism leads to spiny hair in rodents |
title_full_unstemmed |
Divergent genetic mechanism leads to spiny hair in rodents |
title_sort |
Divergent genetic mechanism leads to spiny hair in rodents |
author |
Gonçalves, Gislene Lopes |
author_facet |
Gonçalves, Gislene Lopes Maestri, Renan Moreira, Gilson Rudinei Pires Jacobi, Marly Antonia Maldaner Freitas, Thales Renato Ochotorena de Hoekstra, Hopi E. |
author_role |
author |
author2 |
Maestri, Renan Moreira, Gilson Rudinei Pires Jacobi, Marly Antonia Maldaner Freitas, Thales Renato Ochotorena de Hoekstra, Hopi E. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gonçalves, Gislene Lopes Maestri, Renan Moreira, Gilson Rudinei Pires Jacobi, Marly Antonia Maldaner Freitas, Thales Renato Ochotorena de Hoekstra, Hopi E. |
dc.subject.por.fl_str_mv |
Ruído : Efeitos adversos Cabelo espinhoso Roedores Genética |
topic |
Ruído : Efeitos adversos Cabelo espinhoso Roedores Genética |
description |
Spines, or modified hairs, have evolved multiple times in mammals, particularly in rodents. In this study, we investigated the evolution of spines in six rodent families. We first measured and compared the morphology and physical properties of hairs between paired spiny and non-spiny sister lineages. We found two distinct hair morphologies had evolved repeatedly in spiny rodents: hairs with a grooved cross-section and a second near cylindrical form. Compared to the ancestral elliptical-shaped hairs, spiny hairs had higher tension and stiffness, and overall, hairs with similar morphology had similar functional properties. To examine the genetic basis of this convergent evolution, we tested whether a single amino acid change (V370A) in the Ectodysplasin A receptor (Edar) gene is associated with spiny hair, as this substitution causes thicker and straighter hair in East Asian human populations. We found that most mammals have the common amino acid valine at position 370, but two species, the kangaroo rat (non-spiny) and spiny pocket mouse (spiny), have an isoleucine. Importantly, none of the variants we identified are associated with differences in rodent hair morphology. Thus, the specific Edar mutation associated with variation in human hair does not seem to play a role in modifying hairs in wild rodents, suggesting that different mutations in Edar and/or other genes are responsible for variation in the spiny hair phenotypes we observed within rodents. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2021-07-30T04:36:46Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/224823 |
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1932-6203 |
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001099568 |
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1932-6203 001099568 |
url |
http://hdl.handle.net/10183/224823 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PLoS ONE. San Francisco. Vol. 13, no. 8 (Aug. 2018), e0202219, 16 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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