Humanistic and economic impact of moderate to severe plaque psoriasis in Brazil

Detalhes bibliográficos
Autor(a) principal: Lopes, Nilcéia
Data de Publicação: 2019
Outros Autores: Dias, Leticia L. S., Abulafia, Luna Azulay, Oyafuso, Luiza Keiko Matsuka, Suarez, Maria Victoria, Fabrício, Lincoln Helder Zambaldi, Kobata, Clarice Marie, Cestari, Tania Ferreira, Gontijo, Bernardo, Sabbag, Cid Y., Antonio, João Roberto, Romiti, Ricardo, Pertel, Patricia C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/215096
Resumo: Introduction Psoriasis is an immune-mediated, chronic, inflammatory disease, which has a substantial humanistic and economic burden. This study aimed to assess the impact of this disease on health-related quality of life (HRQoL), work productivity, and direct and indirect costs from a societal perspective among Brazilian patients. Methods This is a cross-sectional, observational, multicenter study, enrolling patients with moderate to severe plaque psoriasis according to physician evaluation. Data collection was performed from December 2015 to November 2016 through face-to-face interviews using a structured questionnaire and five standardized patient-reported outcomes instruments. Direct costs were estimated by multiplying the amount of resources used (12-month recall period) by the corresponding unit cost. Indirect costs were grouped in two time horizons: annual costs (income reduction and absenteeism) and lifetime costs (demission and early retirement). Results A total of 188 patients with moderate to severe plaque psoriasis were included, with mean age of 48.0 (SD 13.1). “Anxiety and depression” and “pain and discomfort” were the most impaired dimensions, according to the EuroQol Five-Dimension-Three-Level (EQ-5D-3L). The highest effect was found for “symptoms and feelings” [mean (SD) 2.4 (1.7)] Dermatology Life Quality Index (DLQI) subscale. Psoriatic arthritis (PsA) presence and biologic-naïve status were associated with worse HRQoL. Presenteeism was more frequent than absenteeism, according to the Work Productivity and Activity Impairment questionnaire-General Health (WPAI-GH) [17.4% vs. 6.3%], while physical demands and time management were the most affected Work Limitations Questionnaire (WLQ) subscales [means (SD) 23.5 (28.5) and 17.7 (24.9), respectively]. The estimated annual cost per patient was USD 4034. Direct medical costs accounted for 87.7% of this estimate, direct non-medical costs for 2.4%, and indirect costs for 9.9%. Conclusions Results evidenced that moderate to severe plaque psoriasis imposes substantial costs to society. Our data showed that this disease negatively affects both work productivity and HRQoL of Brazilian patients. Subgroups with PsA and biologic-naïve patients presented lower HRQoL, showing the impact of this comorbidity and the relevance of biologics in psoriasis treatment.
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spelling Lopes, NilcéiaDias, Leticia L. S.Abulafia, Luna AzulayOyafuso, Luiza Keiko MatsukaSuarez, Maria VictoriaFabrício, Lincoln Helder ZambaldiKobata, Clarice MarieCestari, Tania FerreiraGontijo, BernardoSabbag, Cid Y.Antonio, João RobertoRomiti, RicardoPertel, Patricia C.2020-11-18T04:09:40Z20190741-238Xhttp://hdl.handle.net/10183/215096001118209Introduction Psoriasis is an immune-mediated, chronic, inflammatory disease, which has a substantial humanistic and economic burden. This study aimed to assess the impact of this disease on health-related quality of life (HRQoL), work productivity, and direct and indirect costs from a societal perspective among Brazilian patients. Methods This is a cross-sectional, observational, multicenter study, enrolling patients with moderate to severe plaque psoriasis according to physician evaluation. Data collection was performed from December 2015 to November 2016 through face-to-face interviews using a structured questionnaire and five standardized patient-reported outcomes instruments. Direct costs were estimated by multiplying the amount of resources used (12-month recall period) by the corresponding unit cost. Indirect costs were grouped in two time horizons: annual costs (income reduction and absenteeism) and lifetime costs (demission and early retirement). Results A total of 188 patients with moderate to severe plaque psoriasis were included, with mean age of 48.0 (SD 13.1). “Anxiety and depression” and “pain and discomfort” were the most impaired dimensions, according to the EuroQol Five-Dimension-Three-Level (EQ-5D-3L). The highest effect was found for “symptoms and feelings” [mean (SD) 2.4 (1.7)] Dermatology Life Quality Index (DLQI) subscale. Psoriatic arthritis (PsA) presence and biologic-naïve status were associated with worse HRQoL. Presenteeism was more frequent than absenteeism, according to the Work Productivity and Activity Impairment questionnaire-General Health (WPAI-GH) [17.4% vs. 6.3%], while physical demands and time management were the most affected Work Limitations Questionnaire (WLQ) subscales [means (SD) 23.5 (28.5) and 17.7 (24.9), respectively]. The estimated annual cost per patient was USD 4034. Direct medical costs accounted for 87.7% of this estimate, direct non-medical costs for 2.4%, and indirect costs for 9.9%. Conclusions Results evidenced that moderate to severe plaque psoriasis imposes substantial costs to society. Our data showed that this disease negatively affects both work productivity and HRQoL of Brazilian patients. Subgroups with PsA and biologic-naïve patients presented lower HRQoL, showing the impact of this comorbidity and the relevance of biologics in psoriasis treatment.application/pdfengAdvances in therapy. New York. Vol. 36 (2019), p. 2849–2865PsoríaseAvaliação em saúdeEfeitos psicossociais da doençaQualidade de vidaBrasilHumanistic and economic impact of moderate to severe plaque psoriasis in BrazilEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001118209.pdf.txt001118209.pdf.txtExtracted Texttext/plain55716http://www.lume.ufrgs.br/bitstream/10183/215096/2/001118209.pdf.txt7b0f85a696f29d44654822fbf8584ebeMD52ORIGINAL001118209.pdfTexto completo (inglês)application/pdf511354http://www.lume.ufrgs.br/bitstream/10183/215096/1/001118209.pdf579b6ea0acdb7f0469a83684630f4b30MD5110183/2150962020-11-19 05:15:48.572308oai:www.lume.ufrgs.br:10183/215096Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2020-11-19T07:15:48Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Humanistic and economic impact of moderate to severe plaque psoriasis in Brazil
title Humanistic and economic impact of moderate to severe plaque psoriasis in Brazil
spellingShingle Humanistic and economic impact of moderate to severe plaque psoriasis in Brazil
Lopes, Nilcéia
Psoríase
Avaliação em saúde
Efeitos psicossociais da doença
Qualidade de vida
Brasil
title_short Humanistic and economic impact of moderate to severe plaque psoriasis in Brazil
title_full Humanistic and economic impact of moderate to severe plaque psoriasis in Brazil
title_fullStr Humanistic and economic impact of moderate to severe plaque psoriasis in Brazil
title_full_unstemmed Humanistic and economic impact of moderate to severe plaque psoriasis in Brazil
title_sort Humanistic and economic impact of moderate to severe plaque psoriasis in Brazil
author Lopes, Nilcéia
author_facet Lopes, Nilcéia
Dias, Leticia L. S.
Abulafia, Luna Azulay
Oyafuso, Luiza Keiko Matsuka
Suarez, Maria Victoria
Fabrício, Lincoln Helder Zambaldi
Kobata, Clarice Marie
Cestari, Tania Ferreira
Gontijo, Bernardo
Sabbag, Cid Y.
Antonio, João Roberto
Romiti, Ricardo
Pertel, Patricia C.
author_role author
author2 Dias, Leticia L. S.
Abulafia, Luna Azulay
Oyafuso, Luiza Keiko Matsuka
Suarez, Maria Victoria
Fabrício, Lincoln Helder Zambaldi
Kobata, Clarice Marie
Cestari, Tania Ferreira
Gontijo, Bernardo
Sabbag, Cid Y.
Antonio, João Roberto
Romiti, Ricardo
Pertel, Patricia C.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes, Nilcéia
Dias, Leticia L. S.
Abulafia, Luna Azulay
Oyafuso, Luiza Keiko Matsuka
Suarez, Maria Victoria
Fabrício, Lincoln Helder Zambaldi
Kobata, Clarice Marie
Cestari, Tania Ferreira
Gontijo, Bernardo
Sabbag, Cid Y.
Antonio, João Roberto
Romiti, Ricardo
Pertel, Patricia C.
dc.subject.por.fl_str_mv Psoríase
Avaliação em saúde
Efeitos psicossociais da doença
Qualidade de vida
Brasil
topic Psoríase
Avaliação em saúde
Efeitos psicossociais da doença
Qualidade de vida
Brasil
description Introduction Psoriasis is an immune-mediated, chronic, inflammatory disease, which has a substantial humanistic and economic burden. This study aimed to assess the impact of this disease on health-related quality of life (HRQoL), work productivity, and direct and indirect costs from a societal perspective among Brazilian patients. Methods This is a cross-sectional, observational, multicenter study, enrolling patients with moderate to severe plaque psoriasis according to physician evaluation. Data collection was performed from December 2015 to November 2016 through face-to-face interviews using a structured questionnaire and five standardized patient-reported outcomes instruments. Direct costs were estimated by multiplying the amount of resources used (12-month recall period) by the corresponding unit cost. Indirect costs were grouped in two time horizons: annual costs (income reduction and absenteeism) and lifetime costs (demission and early retirement). Results A total of 188 patients with moderate to severe plaque psoriasis were included, with mean age of 48.0 (SD 13.1). “Anxiety and depression” and “pain and discomfort” were the most impaired dimensions, according to the EuroQol Five-Dimension-Three-Level (EQ-5D-3L). The highest effect was found for “symptoms and feelings” [mean (SD) 2.4 (1.7)] Dermatology Life Quality Index (DLQI) subscale. Psoriatic arthritis (PsA) presence and biologic-naïve status were associated with worse HRQoL. Presenteeism was more frequent than absenteeism, according to the Work Productivity and Activity Impairment questionnaire-General Health (WPAI-GH) [17.4% vs. 6.3%], while physical demands and time management were the most affected Work Limitations Questionnaire (WLQ) subscales [means (SD) 23.5 (28.5) and 17.7 (24.9), respectively]. The estimated annual cost per patient was USD 4034. Direct medical costs accounted for 87.7% of this estimate, direct non-medical costs for 2.4%, and indirect costs for 9.9%. Conclusions Results evidenced that moderate to severe plaque psoriasis imposes substantial costs to society. Our data showed that this disease negatively affects both work productivity and HRQoL of Brazilian patients. Subgroups with PsA and biologic-naïve patients presented lower HRQoL, showing the impact of this comorbidity and the relevance of biologics in psoriasis treatment.
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