Predictors of the progression of dementia severity in Brazilian patients with Alzheimer’s disease and vascular dementia

Detalhes bibliográficos
Autor(a) principal: Chaves, Marcia Lorena Fagundes
Data de Publicação: 2010
Outros Autores: Pádua, Analuiza Camozzato de, Kohler, Cristiano André, Kaye, Jeffrey
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/225860
Resumo: Introduction. This study evaluates the progression of dementia and identifies prognostic risk factors for dementia. Methods. A group of 80 Brazilian community residents with dementia (34 with Alzheimer’s disease and 46 with vascular dementia) was assessed over the course of 2 years. Data were analyzed with Cox regression survival analysis. Results. The data showed that education predicted cognitive decline (HR = 1.2; P<.05) when analyzed without controlling for vascular risk factors. After the inclusion of vascular risk factors, education (HR = 1.32; P<.05) and hypertension were predictive for cognitive decline (HR = 38; P<.05), and Alzheimer’s disease diagnosis was borderline predictive (P = .055). Conclusion. Vascular risk factors interacted with the diagnosis of vascular dementia. Education was a strong predictor of decline.
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spelling Chaves, Marcia Lorena FagundesPádua, Analuiza Camozzato deKohler, Cristiano AndréKaye, Jeffrey2021-08-18T04:46:17Z20102090-0252http://hdl.handle.net/10183/225860000761246Introduction. This study evaluates the progression of dementia and identifies prognostic risk factors for dementia. Methods. A group of 80 Brazilian community residents with dementia (34 with Alzheimer’s disease and 46 with vascular dementia) was assessed over the course of 2 years. Data were analyzed with Cox regression survival analysis. Results. The data showed that education predicted cognitive decline (HR = 1.2; P<.05) when analyzed without controlling for vascular risk factors. After the inclusion of vascular risk factors, education (HR = 1.32; P<.05) and hypertension were predictive for cognitive decline (HR = 38; P<.05), and Alzheimer’s disease diagnosis was borderline predictive (P = .055). Conclusion. Vascular risk factors interacted with the diagnosis of vascular dementia. Education was a strong predictor of decline.application/pdfengInternational Journal of Alzheimer’s Disease. London. Vol. 2010 (2010), 7 p.Doença de AlzheimerDemência vascularPredictors of the progression of dementia severity in Brazilian patients with Alzheimer’s disease and vascular dementiaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000761246.pdf.txt000761246.pdf.txtExtracted Texttext/plain37472http://www.lume.ufrgs.br/bitstream/10183/225860/2/000761246.pdf.txt4870a03c4535cc130466a48e839e3422MD52ORIGINAL000761246.pdfTexto completo (inglês)application/pdf1276716http://www.lume.ufrgs.br/bitstream/10183/225860/1/000761246.pdfde40b5841f7b61e8316218ec75fb0f4bMD5110183/2258602021-08-18 05:21:35.306oai:www.lume.ufrgs.br:10183/225860Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-08-18T08:21:35Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Predictors of the progression of dementia severity in Brazilian patients with Alzheimer’s disease and vascular dementia
title Predictors of the progression of dementia severity in Brazilian patients with Alzheimer’s disease and vascular dementia
spellingShingle Predictors of the progression of dementia severity in Brazilian patients with Alzheimer’s disease and vascular dementia
Chaves, Marcia Lorena Fagundes
Doença de Alzheimer
Demência vascular
title_short Predictors of the progression of dementia severity in Brazilian patients with Alzheimer’s disease and vascular dementia
title_full Predictors of the progression of dementia severity in Brazilian patients with Alzheimer’s disease and vascular dementia
title_fullStr Predictors of the progression of dementia severity in Brazilian patients with Alzheimer’s disease and vascular dementia
title_full_unstemmed Predictors of the progression of dementia severity in Brazilian patients with Alzheimer’s disease and vascular dementia
title_sort Predictors of the progression of dementia severity in Brazilian patients with Alzheimer’s disease and vascular dementia
author Chaves, Marcia Lorena Fagundes
author_facet Chaves, Marcia Lorena Fagundes
Pádua, Analuiza Camozzato de
Kohler, Cristiano André
Kaye, Jeffrey
author_role author
author2 Pádua, Analuiza Camozzato de
Kohler, Cristiano André
Kaye, Jeffrey
author2_role author
author
author
dc.contributor.author.fl_str_mv Chaves, Marcia Lorena Fagundes
Pádua, Analuiza Camozzato de
Kohler, Cristiano André
Kaye, Jeffrey
dc.subject.por.fl_str_mv Doença de Alzheimer
Demência vascular
topic Doença de Alzheimer
Demência vascular
description Introduction. This study evaluates the progression of dementia and identifies prognostic risk factors for dementia. Methods. A group of 80 Brazilian community residents with dementia (34 with Alzheimer’s disease and 46 with vascular dementia) was assessed over the course of 2 years. Data were analyzed with Cox regression survival analysis. Results. The data showed that education predicted cognitive decline (HR = 1.2; P<.05) when analyzed without controlling for vascular risk factors. After the inclusion of vascular risk factors, education (HR = 1.32; P<.05) and hypertension were predictive for cognitive decline (HR = 38; P<.05), and Alzheimer’s disease diagnosis was borderline predictive (P = .055). Conclusion. Vascular risk factors interacted with the diagnosis of vascular dementia. Education was a strong predictor of decline.
publishDate 2010
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dc.relation.ispartof.pt_BR.fl_str_mv International Journal of Alzheimer’s Disease. London. Vol. 2010 (2010), 7 p.
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