HIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as prevention
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/206228 |
Resumo: | Objectives: HIV-1 heterosexual transmission among individuals on antiretroviral treatment (ART) with undetectable viremia is extremely rare. The aim of this study was to evaluate the risk of sexual HIV-1 transmission and other sexually transmitted infections (STIs) in HIV-1 serodifferent couples while the index partner is on ART. Methods: HIV transmission was evaluated in 200 HIV-1 heterosexual serodifferent couples in a stable relationship (≥3 months). All HIV-positive individuals had been on ART for ≥3 months and had been followed up for a median preceding time of 4.5 years (range 0.3–16 years) at the HIV couples clinic at Hospital Nossa Senhora da Conceição in Porto Alegre, Brazil. Following written informed consent, participants responded to demographic/behavioral questionnaires. Quantitative PCR for HIV RNA, T-cell subsets, and STI testing (syphilis, herpes, human papillomavirus, gonorrhea, and bacterial vaginosis) were performed. Self-collected vaginal swabs were obtained for quantitative HIV genital viral load testing. Results: Among 200 couples, 70% of index partners were female. Five seroconversions were observed; the HIV infection incidence was 2.5% (95% confidence interval 0.8% to 5.7%). Mean plasma viral load results were higher in HIV transmitters compared to non-transmitters (p = 0.02). The presence of STIs was significantly greater in couples who seroconverted (60.0% vs. 13.3%; odds ratio 9.75, 95% confidence interval 1.55–61.2; p = 0.023). The duration of undetectable HIV viremia and presence of STIs were associated with HIV transmission. Conclusions: Undetectable viremia was the main factor associated with non-transmissibility of HIV in this setting. |
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Melo, Marineide Gonçalves deSprinz, EduardoGorbach, Pamina M.Santos, Breno Riegel dosRocha, Tauí de MeloMoesch, Mariana Riegel de Pádua SimonAzambuja, Marcelo AlmeidaLira, RitaSeter, Maria Cristina ChavesKerin, TaraVarella, Ivana Rosângela dos SantosNielsen-Saines, Karin A.2020-02-22T04:21:52Z20191201-9712http://hdl.handle.net/10183/206228001111626Objectives: HIV-1 heterosexual transmission among individuals on antiretroviral treatment (ART) with undetectable viremia is extremely rare. The aim of this study was to evaluate the risk of sexual HIV-1 transmission and other sexually transmitted infections (STIs) in HIV-1 serodifferent couples while the index partner is on ART. Methods: HIV transmission was evaluated in 200 HIV-1 heterosexual serodifferent couples in a stable relationship (≥3 months). All HIV-positive individuals had been on ART for ≥3 months and had been followed up for a median preceding time of 4.5 years (range 0.3–16 years) at the HIV couples clinic at Hospital Nossa Senhora da Conceição in Porto Alegre, Brazil. Following written informed consent, participants responded to demographic/behavioral questionnaires. Quantitative PCR for HIV RNA, T-cell subsets, and STI testing (syphilis, herpes, human papillomavirus, gonorrhea, and bacterial vaginosis) were performed. Self-collected vaginal swabs were obtained for quantitative HIV genital viral load testing. Results: Among 200 couples, 70% of index partners were female. Five seroconversions were observed; the HIV infection incidence was 2.5% (95% confidence interval 0.8% to 5.7%). Mean plasma viral load results were higher in HIV transmitters compared to non-transmitters (p = 0.02). The presence of STIs was significantly greater in couples who seroconverted (60.0% vs. 13.3%; odds ratio 9.75, 95% confidence interval 1.55–61.2; p = 0.023). The duration of undetectable HIV viremia and presence of STIs were associated with HIV transmission. Conclusions: Undetectable viremia was the main factor associated with non-transmissibility of HIV in this setting.application/pdfengInternational journal of infectious diseases. Hamilton. vol. 87 (Oct. 2019), p. 128-134HIVAntirretroviraisInfecções sexualmente transmissíveisHIV-1 transmissionCouplesSTIsART for preventionHIV-1 transmissionHIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as preventionEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001111626.pdf.txt001111626.pdf.txtExtracted Texttext/plain42709http://www.lume.ufrgs.br/bitstream/10183/206228/2/001111626.pdf.txtabf5797a8c997ee4b198763bfc127a39MD52ORIGINAL001111626.pdfTexto completo (inglês)application/pdf709362http://www.lume.ufrgs.br/bitstream/10183/206228/1/001111626.pdf7a076bfa69eec951995cc5633616cb20MD5110183/2062282023-09-14 03:26:23.579855oai:www.lume.ufrgs.br:10183/206228Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-14T06:26:23Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
HIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as prevention |
title |
HIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as prevention |
spellingShingle |
HIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as prevention Melo, Marineide Gonçalves de HIV Antirretrovirais Infecções sexualmente transmissíveis HIV-1 transmission Couples STIs ART for prevention HIV-1 transmission |
title_short |
HIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as prevention |
title_full |
HIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as prevention |
title_fullStr |
HIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as prevention |
title_full_unstemmed |
HIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as prevention |
title_sort |
HIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as prevention |
author |
Melo, Marineide Gonçalves de |
author_facet |
Melo, Marineide Gonçalves de Sprinz, Eduardo Gorbach, Pamina M. Santos, Breno Riegel dos Rocha, Tauí de Melo Moesch, Mariana Riegel de Pádua Simon Azambuja, Marcelo Almeida Lira, Rita Seter, Maria Cristina Chaves Kerin, Tara Varella, Ivana Rosângela dos Santos Nielsen-Saines, Karin A. |
author_role |
author |
author2 |
Sprinz, Eduardo Gorbach, Pamina M. Santos, Breno Riegel dos Rocha, Tauí de Melo Moesch, Mariana Riegel de Pádua Simon Azambuja, Marcelo Almeida Lira, Rita Seter, Maria Cristina Chaves Kerin, Tara Varella, Ivana Rosângela dos Santos Nielsen-Saines, Karin A. |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Melo, Marineide Gonçalves de Sprinz, Eduardo Gorbach, Pamina M. Santos, Breno Riegel dos Rocha, Tauí de Melo Moesch, Mariana Riegel de Pádua Simon Azambuja, Marcelo Almeida Lira, Rita Seter, Maria Cristina Chaves Kerin, Tara Varella, Ivana Rosângela dos Santos Nielsen-Saines, Karin A. |
dc.subject.por.fl_str_mv |
HIV Antirretrovirais Infecções sexualmente transmissíveis |
topic |
HIV Antirretrovirais Infecções sexualmente transmissíveis HIV-1 transmission Couples STIs ART for prevention HIV-1 transmission |
dc.subject.eng.fl_str_mv |
HIV-1 transmission Couples STIs ART for prevention HIV-1 transmission |
description |
Objectives: HIV-1 heterosexual transmission among individuals on antiretroviral treatment (ART) with undetectable viremia is extremely rare. The aim of this study was to evaluate the risk of sexual HIV-1 transmission and other sexually transmitted infections (STIs) in HIV-1 serodifferent couples while the index partner is on ART. Methods: HIV transmission was evaluated in 200 HIV-1 heterosexual serodifferent couples in a stable relationship (≥3 months). All HIV-positive individuals had been on ART for ≥3 months and had been followed up for a median preceding time of 4.5 years (range 0.3–16 years) at the HIV couples clinic at Hospital Nossa Senhora da Conceição in Porto Alegre, Brazil. Following written informed consent, participants responded to demographic/behavioral questionnaires. Quantitative PCR for HIV RNA, T-cell subsets, and STI testing (syphilis, herpes, human papillomavirus, gonorrhea, and bacterial vaginosis) were performed. Self-collected vaginal swabs were obtained for quantitative HIV genital viral load testing. Results: Among 200 couples, 70% of index partners were female. Five seroconversions were observed; the HIV infection incidence was 2.5% (95% confidence interval 0.8% to 5.7%). Mean plasma viral load results were higher in HIV transmitters compared to non-transmitters (p = 0.02). The presence of STIs was significantly greater in couples who seroconverted (60.0% vs. 13.3%; odds ratio 9.75, 95% confidence interval 1.55–61.2; p = 0.023). The duration of undetectable HIV viremia and presence of STIs were associated with HIV transmission. Conclusions: Undetectable viremia was the main factor associated with non-transmissibility of HIV in this setting. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2020-02-22T04:21:52Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/206228 |
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1201-9712 |
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001111626 |
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http://hdl.handle.net/10183/206228 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
International journal of infectious diseases. Hamilton. vol. 87 (Oct. 2019), p. 128-134 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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