The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/62041 |
Resumo: | Background: The expression of CD56 is considered a bad prognostic factor for overall survival, lower rates or short complete remission and extramedullary invasion but the results are controversial. The importance of validating new prognostic parameters in acute leukemias was the reason to investigate the CD56 expression in blast cells of patients with acute myeloid leukemia. Methods: A cohort of 48 patients treated at Hospital de Clinicas de Porto Alegre and diagnosed with acute myeloid leukemia as classified by the French-American-British group (FAB) criteria using cell morphology, cytochemistry and flow cytometry were evaluated. Results: Eight cases (16.7%) were CD56 positive without correlation to age or gender. The highest incidence of CD56 positivity was in FAB subtypes M4 and M5. The death rate during induction was not significantly different between patients with and without CD56 expression (62.5% vs. 27.5%; p-value = 0.097). However, patients that expressed CD56 had significantly lower overall survival than those who did not (mean 4.0 months vs. 14.5 months; p-value = 0.03). Conclusions: The data suggest that expression of CD56 in acute myeloid leukemia may be indicative of poor prognosis because it is associated with a shorter overall survival. The death rate during induction was not significantly different despite an apparent difference in proportions between groups. |
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Alegretti, Ana PaulaBittar, Christina MatzenbacherBittencourt, Rosane IsabelPiccoli, Amanda KirchnerSchneider, LaianaSilla, Lucia Mariano da RochaDal Bó, SuzaneXavier, Ricardo Machado2012-12-28T01:35:52Z20111516-8484http://hdl.handle.net/10183/62041000790385Background: The expression of CD56 is considered a bad prognostic factor for overall survival, lower rates or short complete remission and extramedullary invasion but the results are controversial. The importance of validating new prognostic parameters in acute leukemias was the reason to investigate the CD56 expression in blast cells of patients with acute myeloid leukemia. Methods: A cohort of 48 patients treated at Hospital de Clinicas de Porto Alegre and diagnosed with acute myeloid leukemia as classified by the French-American-British group (FAB) criteria using cell morphology, cytochemistry and flow cytometry were evaluated. Results: Eight cases (16.7%) were CD56 positive without correlation to age or gender. The highest incidence of CD56 positivity was in FAB subtypes M4 and M5. The death rate during induction was not significantly different between patients with and without CD56 expression (62.5% vs. 27.5%; p-value = 0.097). However, patients that expressed CD56 had significantly lower overall survival than those who did not (mean 4.0 months vs. 14.5 months; p-value = 0.03). Conclusions: The data suggest that expression of CD56 in acute myeloid leukemia may be indicative of poor prognosis because it is associated with a shorter overall survival. The death rate during induction was not significantly different despite an apparent difference in proportions between groups.application/pdfporRevista brasileira de hematologia e hemoterapia = Brazilian journal of hematology and hemotherapy. São Paulo. Vol. 33, n. 3 (2011), p. 202-206AntigenosAntígenos CD56Leucemia mielóidePrognósticoAntigens, CD56Leukemia, MyeloidPrognosisThe expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemiainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000790385.pdf000790385.pdfTexto completo (inglês)application/pdf360201http://www.lume.ufrgs.br/bitstream/10183/62041/1/000790385.pdf3edde6048873b71d8a181ef06215610cMD51TEXT000790385.pdf.txt000790385.pdf.txtExtracted Texttext/plain23616http://www.lume.ufrgs.br/bitstream/10183/62041/2/000790385.pdf.txtaea74a9743b2a6186efb6433a86e4d62MD52THUMBNAIL000790385.pdf.jpg000790385.pdf.jpgGenerated Thumbnailimage/jpeg2261http://www.lume.ufrgs.br/bitstream/10183/62041/3/000790385.pdf.jpg0d4393a00c08ae011df71aa7ce69402cMD5310183/620412018-10-16 08:46:52.03oai:www.lume.ufrgs.br:10183/62041Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-16T11:46:52Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia |
title |
The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia |
spellingShingle |
The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia Alegretti, Ana Paula Antigenos Antígenos CD56 Leucemia mielóide Prognóstico Antigens, CD56 Leukemia, Myeloid Prognosis |
title_short |
The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia |
title_full |
The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia |
title_fullStr |
The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia |
title_full_unstemmed |
The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia |
title_sort |
The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia |
author |
Alegretti, Ana Paula |
author_facet |
Alegretti, Ana Paula Bittar, Christina Matzenbacher Bittencourt, Rosane Isabel Piccoli, Amanda Kirchner Schneider, Laiana Silla, Lucia Mariano da Rocha Dal Bó, Suzane Xavier, Ricardo Machado |
author_role |
author |
author2 |
Bittar, Christina Matzenbacher Bittencourt, Rosane Isabel Piccoli, Amanda Kirchner Schneider, Laiana Silla, Lucia Mariano da Rocha Dal Bó, Suzane Xavier, Ricardo Machado |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Alegretti, Ana Paula Bittar, Christina Matzenbacher Bittencourt, Rosane Isabel Piccoli, Amanda Kirchner Schneider, Laiana Silla, Lucia Mariano da Rocha Dal Bó, Suzane Xavier, Ricardo Machado |
dc.subject.por.fl_str_mv |
Antigenos Antígenos CD56 Leucemia mielóide Prognóstico |
topic |
Antigenos Antígenos CD56 Leucemia mielóide Prognóstico Antigens, CD56 Leukemia, Myeloid Prognosis |
dc.subject.eng.fl_str_mv |
Antigens, CD56 Leukemia, Myeloid Prognosis |
description |
Background: The expression of CD56 is considered a bad prognostic factor for overall survival, lower rates or short complete remission and extramedullary invasion but the results are controversial. The importance of validating new prognostic parameters in acute leukemias was the reason to investigate the CD56 expression in blast cells of patients with acute myeloid leukemia. Methods: A cohort of 48 patients treated at Hospital de Clinicas de Porto Alegre and diagnosed with acute myeloid leukemia as classified by the French-American-British group (FAB) criteria using cell morphology, cytochemistry and flow cytometry were evaluated. Results: Eight cases (16.7%) were CD56 positive without correlation to age or gender. The highest incidence of CD56 positivity was in FAB subtypes M4 and M5. The death rate during induction was not significantly different between patients with and without CD56 expression (62.5% vs. 27.5%; p-value = 0.097). However, patients that expressed CD56 had significantly lower overall survival than those who did not (mean 4.0 months vs. 14.5 months; p-value = 0.03). Conclusions: The data suggest that expression of CD56 in acute myeloid leukemia may be indicative of poor prognosis because it is associated with a shorter overall survival. The death rate during induction was not significantly different despite an apparent difference in proportions between groups. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
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2012-12-28T01:35:52Z |
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000790385 |
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por |
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por |
dc.relation.ispartof.pt_BR.fl_str_mv |
Revista brasileira de hematologia e hemoterapia = Brazilian journal of hematology and hemotherapy. São Paulo. Vol. 33, n. 3 (2011), p. 202-206 |
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