Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/108693 |
Resumo: | OBJECTIVES: We evaluated the effects of aerobic exercise training without dietary changes on cardiovascular and metabolic variables and on the expression of glucose transporter Type 4 in rats with metabolic syndrome. METHODS: Twenty male spontaneously hypertensive rats received monosodium glutamate during the neonatal period. The animals were allocated to the following groups: MS (sedentary metabolic syndrome), MS-T (trained on a treadmill for 1 hour/day, 5 days/week for 10 weeks), H (sedentary spontaneously hypertensive rats) and H-T (trained spontaneously hypertensive rats). The Lee index, blood pressure (tail-cuff system), insulin sensitivity (insulin tolerance test) and functional capacity were evaluated before and after 10 weeks of training. Glucose transporter Type 4 expression was analyzed using Western blotting. The datawere compared using analysis of variance (ANOVA) (p,0.05). RESULTS: At baseline, the MS rats exhibited lower insulin sensitivity and increased Lee index comparedwith the H rats. Training decreased the body weight and Lee index of the MS rats (MS-T vs. MS), but not of the H rats (H-T vs. H). There were no differences in food intake between the groups. At the end of the experiments, the systolic blood pressure was lower in the two trained groups than in their sedentary controls. Whole-body insulin sensitivity increased in the trained groups. Glucose transporter Type 4 content increased in the heart, white adipose tissue and gastrocnemius muscle of the trained groups relative to their respective untrained groups. CONCLUSION: In conclusion, the present study shows that an isolated aerobic exercise training intervention is an efficient means of improving several components of metabolic syndrome, that is, training reduces obesity and hypertension and increases insulin sensitivity. |
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Caponi, Paula WesendonckLehnen, Alexandre MachadoPinto, Graziela HünningBorges, JuliaMarkoski, Melissa MedeirosMachado, Ubiratan FabresSchaan, Beatriz D'Agord2014-12-25T02:10:33Z20131807-5932http://hdl.handle.net/10183/108693000898478OBJECTIVES: We evaluated the effects of aerobic exercise training without dietary changes on cardiovascular and metabolic variables and on the expression of glucose transporter Type 4 in rats with metabolic syndrome. METHODS: Twenty male spontaneously hypertensive rats received monosodium glutamate during the neonatal period. The animals were allocated to the following groups: MS (sedentary metabolic syndrome), MS-T (trained on a treadmill for 1 hour/day, 5 days/week for 10 weeks), H (sedentary spontaneously hypertensive rats) and H-T (trained spontaneously hypertensive rats). The Lee index, blood pressure (tail-cuff system), insulin sensitivity (insulin tolerance test) and functional capacity were evaluated before and after 10 weeks of training. Glucose transporter Type 4 expression was analyzed using Western blotting. The datawere compared using analysis of variance (ANOVA) (p,0.05). RESULTS: At baseline, the MS rats exhibited lower insulin sensitivity and increased Lee index comparedwith the H rats. Training decreased the body weight and Lee index of the MS rats (MS-T vs. MS), but not of the H rats (H-T vs. H). There were no differences in food intake between the groups. At the end of the experiments, the systolic blood pressure was lower in the two trained groups than in their sedentary controls. Whole-body insulin sensitivity increased in the trained groups. Glucose transporter Type 4 content increased in the heart, white adipose tissue and gastrocnemius muscle of the trained groups relative to their respective untrained groups. CONCLUSION: In conclusion, the present study shows that an isolated aerobic exercise training intervention is an efficient means of improving several components of metabolic syndrome, that is, training reduces obesity and hypertension and increases insulin sensitivity.application/pdfengClinics. São Paulo. Vol. 68, no. 7 (2013), p. 1010-1017.Síndrome metabólicaTransportador de glucose tipo 4ObesidadeExercício físicoMetabolic syndrome XGlucose transporter type 4ObesityExercise trainingAerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000898478.pdf000898478.pdfTexto completo (inglês)application/pdf622485http://www.lume.ufrgs.br/bitstream/10183/108693/1/000898478.pdf68602f2e9fd2a33409826c6354e4f4c2MD51TEXT000898478.pdf.txt000898478.pdf.txtExtracted Texttext/plain42226http://www.lume.ufrgs.br/bitstream/10183/108693/2/000898478.pdf.txtd9c2da980a8f4d770ef07f203d129cb4MD52THUMBNAIL000898478.pdf.jpg000898478.pdf.jpgGenerated Thumbnailimage/jpeg2229http://www.lume.ufrgs.br/bitstream/10183/108693/3/000898478.pdf.jpg5644cb03f93ee9c1e1e9b544e527624cMD5310183/1086932023-08-27 03:43:10.704076oai:www.lume.ufrgs.br:10183/108693Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-27T06:43:10Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes |
title |
Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes |
spellingShingle |
Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes Caponi, Paula Wesendonck Síndrome metabólica Transportador de glucose tipo 4 Obesidade Exercício físico Metabolic syndrome X Glucose transporter type 4 Obesity Exercise training |
title_short |
Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes |
title_full |
Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes |
title_fullStr |
Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes |
title_full_unstemmed |
Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes |
title_sort |
Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes |
author |
Caponi, Paula Wesendonck |
author_facet |
Caponi, Paula Wesendonck Lehnen, Alexandre Machado Pinto, Graziela Hünning Borges, Julia Markoski, Melissa Medeiros Machado, Ubiratan Fabres Schaan, Beatriz D'Agord |
author_role |
author |
author2 |
Lehnen, Alexandre Machado Pinto, Graziela Hünning Borges, Julia Markoski, Melissa Medeiros Machado, Ubiratan Fabres Schaan, Beatriz D'Agord |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Caponi, Paula Wesendonck Lehnen, Alexandre Machado Pinto, Graziela Hünning Borges, Julia Markoski, Melissa Medeiros Machado, Ubiratan Fabres Schaan, Beatriz D'Agord |
dc.subject.por.fl_str_mv |
Síndrome metabólica Transportador de glucose tipo 4 Obesidade Exercício físico |
topic |
Síndrome metabólica Transportador de glucose tipo 4 Obesidade Exercício físico Metabolic syndrome X Glucose transporter type 4 Obesity Exercise training |
dc.subject.eng.fl_str_mv |
Metabolic syndrome X Glucose transporter type 4 Obesity Exercise training |
description |
OBJECTIVES: We evaluated the effects of aerobic exercise training without dietary changes on cardiovascular and metabolic variables and on the expression of glucose transporter Type 4 in rats with metabolic syndrome. METHODS: Twenty male spontaneously hypertensive rats received monosodium glutamate during the neonatal period. The animals were allocated to the following groups: MS (sedentary metabolic syndrome), MS-T (trained on a treadmill for 1 hour/day, 5 days/week for 10 weeks), H (sedentary spontaneously hypertensive rats) and H-T (trained spontaneously hypertensive rats). The Lee index, blood pressure (tail-cuff system), insulin sensitivity (insulin tolerance test) and functional capacity were evaluated before and after 10 weeks of training. Glucose transporter Type 4 expression was analyzed using Western blotting. The datawere compared using analysis of variance (ANOVA) (p,0.05). RESULTS: At baseline, the MS rats exhibited lower insulin sensitivity and increased Lee index comparedwith the H rats. Training decreased the body weight and Lee index of the MS rats (MS-T vs. MS), but not of the H rats (H-T vs. H). There were no differences in food intake between the groups. At the end of the experiments, the systolic blood pressure was lower in the two trained groups than in their sedentary controls. Whole-body insulin sensitivity increased in the trained groups. Glucose transporter Type 4 content increased in the heart, white adipose tissue and gastrocnemius muscle of the trained groups relative to their respective untrained groups. CONCLUSION: In conclusion, the present study shows that an isolated aerobic exercise training intervention is an efficient means of improving several components of metabolic syndrome, that is, training reduces obesity and hypertension and increases insulin sensitivity. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2014-12-25T02:10:33Z |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/108693 |
dc.identifier.issn.pt_BR.fl_str_mv |
1807-5932 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000898478 |
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http://hdl.handle.net/10183/108693 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Clinics. São Paulo. Vol. 68, no. 7 (2013), p. 1010-1017. |
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openAccess |
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