Infantile hemangiomas : risk factors for complications, recurrence and unaesthetic sequelae
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/243224 |
Resumo: | Background: Infantile hemangiomas (IH) occur in approximately 4% to 10% of the pediatric population. The identification of clinical subtypes and conditions that indicate increased risk for complications is essential for therapeutic success. Objectives: To identify risk factors for complications, recurrence and unaesthetic sequelae. Methods: Retrospective cohort of patients with infantile hemangiomas undergoing follow-up at the Dermatology Service of Universidade Federal de Ciências da Saúde de Porto Alegre, between 2006 and 2018. Results: 190 patients were included; 24% had some type of complication, ulceration being the most frequent, and 86% required treatment. On correlation, ulceration was statistically related to mixed IH (p = 0.004), segmental IH (p < 0.01) and location in the gluteal region (p = 0.001). The mean time of treatment with propranolol was 12.7 months. Patients with PHACES syndrome and segmental infantile hemangioma required longer treatment (p < 0.001 and p = 0.0407, respec- tively), as well as those who started treatment after five months of life (p < 0.0001). Recurrence occurred in 16.6% of the treated patients, all-female; 94% were located on the head and neck (mainly on the upper eyelid, cyrano, S3 segment, and with parotid involvement); 61% and 38.8% were of the mixed and deep subtypes, respectively. Approximately 1/3 of the patients had some unaesthetic sequelae. Study limitations: As this is a retrospective study, data and photos of some patients were lost. Conclusions: Mixed and segmental hemangiomas are risk factors for ulceration and sequelae. Recurrence occurs more often in females and segmental hemangiomas. Segmental infantile hemangioma and PHACES syndrome require a longer time of treatment. Specific protocols are required for infantile hemangiomas with a high risk of recurrence. |
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Mariani, Letícia GaertnerFerreira, Lílian MoraesRovaris, Diego LuizKiszewski, Ana ElisaBonamigo, Renan Rangel2022-07-20T04:49:23Z20220365-0596http://hdl.handle.net/10183/243224001144972Background: Infantile hemangiomas (IH) occur in approximately 4% to 10% of the pediatric population. The identification of clinical subtypes and conditions that indicate increased risk for complications is essential for therapeutic success. Objectives: To identify risk factors for complications, recurrence and unaesthetic sequelae. Methods: Retrospective cohort of patients with infantile hemangiomas undergoing follow-up at the Dermatology Service of Universidade Federal de Ciências da Saúde de Porto Alegre, between 2006 and 2018. Results: 190 patients were included; 24% had some type of complication, ulceration being the most frequent, and 86% required treatment. On correlation, ulceration was statistically related to mixed IH (p = 0.004), segmental IH (p < 0.01) and location in the gluteal region (p = 0.001). The mean time of treatment with propranolol was 12.7 months. Patients with PHACES syndrome and segmental infantile hemangioma required longer treatment (p < 0.001 and p = 0.0407, respec- tively), as well as those who started treatment after five months of life (p < 0.0001). Recurrence occurred in 16.6% of the treated patients, all-female; 94% were located on the head and neck (mainly on the upper eyelid, cyrano, S3 segment, and with parotid involvement); 61% and 38.8% were of the mixed and deep subtypes, respectively. Approximately 1/3 of the patients had some unaesthetic sequelae. Study limitations: As this is a retrospective study, data and photos of some patients were lost. Conclusions: Mixed and segmental hemangiomas are risk factors for ulceration and sequelae. Recurrence occurs more often in females and segmental hemangiomas. Segmental infantile hemangioma and PHACES syndrome require a longer time of treatment. Specific protocols are required for infantile hemangiomas with a high risk of recurrence.application/pdfengAnais brasileiros de dermatologia. Vol. 97, no. 1 (2022), p. 37-44.CriançaDermatopatiasHemangiomaPropranololFatores de riscoRecurrenceRisk factorsScarsInfantile hemangiomas : risk factors for complications, recurrence and unaesthetic sequelaeinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001144972.pdf.txt001144972.pdf.txtExtracted Texttext/plain27799http://www.lume.ufrgs.br/bitstream/10183/243224/2/001144972.pdf.txted969e783946de2797e68380dcb03a9fMD52ORIGINAL001144972.pdfTexto completo (inglês)application/pdf1183776http://www.lume.ufrgs.br/bitstream/10183/243224/1/001144972.pdfd410b1f550b9b165f6c43c0e95a4a046MD5110183/2432242022-07-21 04:55:28.899579oai:www.lume.ufrgs.br:10183/243224Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-07-21T07:55:28Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Infantile hemangiomas : risk factors for complications, recurrence and unaesthetic sequelae |
title |
Infantile hemangiomas : risk factors for complications, recurrence and unaesthetic sequelae |
spellingShingle |
Infantile hemangiomas : risk factors for complications, recurrence and unaesthetic sequelae Mariani, Letícia Gaertner Criança Dermatopatias Hemangioma Propranolol Fatores de risco Recurrence Risk factors Scars |
title_short |
Infantile hemangiomas : risk factors for complications, recurrence and unaesthetic sequelae |
title_full |
Infantile hemangiomas : risk factors for complications, recurrence and unaesthetic sequelae |
title_fullStr |
Infantile hemangiomas : risk factors for complications, recurrence and unaesthetic sequelae |
title_full_unstemmed |
Infantile hemangiomas : risk factors for complications, recurrence and unaesthetic sequelae |
title_sort |
Infantile hemangiomas : risk factors for complications, recurrence and unaesthetic sequelae |
author |
Mariani, Letícia Gaertner |
author_facet |
Mariani, Letícia Gaertner Ferreira, Lílian Moraes Rovaris, Diego Luiz Kiszewski, Ana Elisa Bonamigo, Renan Rangel |
author_role |
author |
author2 |
Ferreira, Lílian Moraes Rovaris, Diego Luiz Kiszewski, Ana Elisa Bonamigo, Renan Rangel |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Mariani, Letícia Gaertner Ferreira, Lílian Moraes Rovaris, Diego Luiz Kiszewski, Ana Elisa Bonamigo, Renan Rangel |
dc.subject.por.fl_str_mv |
Criança Dermatopatias Hemangioma Propranolol Fatores de risco |
topic |
Criança Dermatopatias Hemangioma Propranolol Fatores de risco Recurrence Risk factors Scars |
dc.subject.eng.fl_str_mv |
Recurrence Risk factors Scars |
description |
Background: Infantile hemangiomas (IH) occur in approximately 4% to 10% of the pediatric population. The identification of clinical subtypes and conditions that indicate increased risk for complications is essential for therapeutic success. Objectives: To identify risk factors for complications, recurrence and unaesthetic sequelae. Methods: Retrospective cohort of patients with infantile hemangiomas undergoing follow-up at the Dermatology Service of Universidade Federal de Ciências da Saúde de Porto Alegre, between 2006 and 2018. Results: 190 patients were included; 24% had some type of complication, ulceration being the most frequent, and 86% required treatment. On correlation, ulceration was statistically related to mixed IH (p = 0.004), segmental IH (p < 0.01) and location in the gluteal region (p = 0.001). The mean time of treatment with propranolol was 12.7 months. Patients with PHACES syndrome and segmental infantile hemangioma required longer treatment (p < 0.001 and p = 0.0407, respec- tively), as well as those who started treatment after five months of life (p < 0.0001). Recurrence occurred in 16.6% of the treated patients, all-female; 94% were located on the head and neck (mainly on the upper eyelid, cyrano, S3 segment, and with parotid involvement); 61% and 38.8% were of the mixed and deep subtypes, respectively. Approximately 1/3 of the patients had some unaesthetic sequelae. Study limitations: As this is a retrospective study, data and photos of some patients were lost. Conclusions: Mixed and segmental hemangiomas are risk factors for ulceration and sequelae. Recurrence occurs more often in females and segmental hemangiomas. Segmental infantile hemangioma and PHACES syndrome require a longer time of treatment. Specific protocols are required for infantile hemangiomas with a high risk of recurrence. |
publishDate |
2022 |
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2022-07-20T04:49:23Z |
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2022 |
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publishedVersion |
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http://hdl.handle.net/10183/243224 |
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0365-0596 |
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001144972 |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Anais brasileiros de dermatologia. Vol. 97, no. 1 (2022), p. 37-44. |
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