Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/225251 |
Resumo: | A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 59and 39flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works. |
id |
UFRGS-2_a82deabbb453c9e96f8ec0783061b7dc |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/225251 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Paixão Côrtes, Vanessa RodriguesMeyer, DiogoPereira, Tiago da VeigaMazières, StéphaneElion, JacquesKrishnamoorthy, RajagopalZago, Marco AntonioSilva Junior, Wilson Araujo daSalzano, Francisco MauroBortolini, Maria Cátira2021-08-06T04:41:06Z20111932-6203http://hdl.handle.net/10183/225251000828330A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 59and 39flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works.application/pdfengPLoS ONE. San Francisco. Vol. 6, no. 1 (Jan. 2011), e15656, 7 p.Genética de populaçõesEvolução humanaGene PAX9Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000828330.pdf.txt000828330.pdf.txtExtracted Texttext/plain38764http://www.lume.ufrgs.br/bitstream/10183/225251/2/000828330.pdf.txtdf680637e9679429b0f4eda65d8869eaMD52ORIGINAL000828330.pdfTexto completo (inglês)application/pdf123454http://www.lume.ufrgs.br/bitstream/10183/225251/1/000828330.pdfd60226825215342d1e88594bd5dab869MD5110183/2252512023-09-23 03:34:30.929188oai:www.lume.ufrgs.br:10183/225251Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-23T06:34:30Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
title |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
spellingShingle |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 Paixão Côrtes, Vanessa Rodrigues Genética de populações Evolução humana Gene PAX9 |
title_short |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
title_full |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
title_fullStr |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
title_full_unstemmed |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
title_sort |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
author |
Paixão Côrtes, Vanessa Rodrigues |
author_facet |
Paixão Côrtes, Vanessa Rodrigues Meyer, Diogo Pereira, Tiago da Veiga Mazières, Stéphane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco Antonio Silva Junior, Wilson Araujo da Salzano, Francisco Mauro Bortolini, Maria Cátira |
author_role |
author |
author2 |
Meyer, Diogo Pereira, Tiago da Veiga Mazières, Stéphane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco Antonio Silva Junior, Wilson Araujo da Salzano, Francisco Mauro Bortolini, Maria Cátira |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Paixão Côrtes, Vanessa Rodrigues Meyer, Diogo Pereira, Tiago da Veiga Mazières, Stéphane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco Antonio Silva Junior, Wilson Araujo da Salzano, Francisco Mauro Bortolini, Maria Cátira |
dc.subject.por.fl_str_mv |
Genética de populações Evolução humana Gene PAX9 |
topic |
Genética de populações Evolução humana Gene PAX9 |
description |
A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 59and 39flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2021-08-06T04:41:06Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/225251 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000828330 |
identifier_str_mv |
1932-6203 000828330 |
url |
http://hdl.handle.net/10183/225251 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PLoS ONE. San Francisco. Vol. 6, no. 1 (Jan. 2011), e15656, 7 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/225251/2/000828330.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/225251/1/000828330.pdf |
bitstream.checksum.fl_str_mv |
df680637e9679429b0f4eda65d8869ea d60226825215342d1e88594bd5dab869 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801225031000260608 |