HA-hybrid matrix composite coating on Ti-Cp for biomedical application
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/223362 |
Resumo: | Calcium phosphate coatings have been applied to titanium metal substrates and their alloys as a synergistic alternative capable of combining the mechanical properties of metals and the excellent bioactive properties provided by ceramic materials. However, the unsatisfactory adhesion of hydroxyapatite coatings on metallic substrates, as well as their limitation when subjected to mechanical stresses have been reported as a limitation. Biofunctional coatings have been proposed as an alternative to single ceramic coatings, aiming at optimizing the long-term clinical success of biomaterials such as Ti. This work aims at evaluating the morphological properties and biological behavior of Ti-cp coated with matrix composite coating hydroxyapatite-containing hybrid. The hybrid matrix was obtained from TEOS and MTES silicon precursors, with dispersed hydroxyapatite suspended by dip coating. For the morphological characterization FTIR, SEM/FEG, AFM and contact angle measurement were used. Biological behavior was evaluated for toxicity, cell viability and the osteogenic differentiation capacity of mesenchymal stem cells. The composite coatings obtained showed regular dispersion of hydroxyapatite particles in the hybrid matrix, with uniform coating adhering to the Ti-Cp substrate. Nevertheless, although they provided similar viability behavior of mesenchymal stem cells to the Ti-Cp substrate, the evaluated coatings did not present osteoinductive properties. This result is probably due to the pronounced hydrophobic behavior caused by the incorporation of HA. |
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Boniatti, RosianaBaldin, Estela Knopp KerstnerSteffens, DanielaPavulack, DanielaPranke, Patricia Helena LucasBrandalise, Rosmary NicheleMalfatti, Célia de Fraga2021-07-07T04:35:47Z20200957-4530http://hdl.handle.net/10183/223362001127892Calcium phosphate coatings have been applied to titanium metal substrates and their alloys as a synergistic alternative capable of combining the mechanical properties of metals and the excellent bioactive properties provided by ceramic materials. However, the unsatisfactory adhesion of hydroxyapatite coatings on metallic substrates, as well as their limitation when subjected to mechanical stresses have been reported as a limitation. Biofunctional coatings have been proposed as an alternative to single ceramic coatings, aiming at optimizing the long-term clinical success of biomaterials such as Ti. This work aims at evaluating the morphological properties and biological behavior of Ti-cp coated with matrix composite coating hydroxyapatite-containing hybrid. The hybrid matrix was obtained from TEOS and MTES silicon precursors, with dispersed hydroxyapatite suspended by dip coating. For the morphological characterization FTIR, SEM/FEG, AFM and contact angle measurement were used. Biological behavior was evaluated for toxicity, cell viability and the osteogenic differentiation capacity of mesenchymal stem cells. The composite coatings obtained showed regular dispersion of hydroxyapatite particles in the hybrid matrix, with uniform coating adhering to the Ti-Cp substrate. Nevertheless, although they provided similar viability behavior of mesenchymal stem cells to the Ti-Cp substrate, the evaluated coatings did not present osteoinductive properties. This result is probably due to the pronounced hydrophobic behavior caused by the incorporation of HA.application/pdfengJournal of materials science : materials in medicine. London. Vol. 31 (2020), article 82, p. 1-10TitânioRevestimentos compósitosCompósitos híbridosBiomateriaisHA-hybrid matrix composite coating on Ti-Cp for biomedical applicationEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001127892.pdf.txt001127892.pdf.txtExtracted Texttext/plain43797http://www.lume.ufrgs.br/bitstream/10183/223362/2/001127892.pdf.txtc05dee979ece943a27f6459d80ff2cc9MD52ORIGINAL001127892.pdfTexto completo (inglês)application/pdf2540572http://www.lume.ufrgs.br/bitstream/10183/223362/1/001127892.pdf8784fe793f1f3b1f287cfd4022bd198eMD5110183/2233622021-08-04 04:42:37.283679oai:www.lume.ufrgs.br:10183/223362Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-08-04T07:42:37Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
HA-hybrid matrix composite coating on Ti-Cp for biomedical application |
title |
HA-hybrid matrix composite coating on Ti-Cp for biomedical application |
spellingShingle |
HA-hybrid matrix composite coating on Ti-Cp for biomedical application Boniatti, Rosiana Titânio Revestimentos compósitos Compósitos híbridos Biomateriais |
title_short |
HA-hybrid matrix composite coating on Ti-Cp for biomedical application |
title_full |
HA-hybrid matrix composite coating on Ti-Cp for biomedical application |
title_fullStr |
HA-hybrid matrix composite coating on Ti-Cp for biomedical application |
title_full_unstemmed |
HA-hybrid matrix composite coating on Ti-Cp for biomedical application |
title_sort |
HA-hybrid matrix composite coating on Ti-Cp for biomedical application |
author |
Boniatti, Rosiana |
author_facet |
Boniatti, Rosiana Baldin, Estela Knopp Kerstner Steffens, Daniela Pavulack, Daniela Pranke, Patricia Helena Lucas Brandalise, Rosmary Nichele Malfatti, Célia de Fraga |
author_role |
author |
author2 |
Baldin, Estela Knopp Kerstner Steffens, Daniela Pavulack, Daniela Pranke, Patricia Helena Lucas Brandalise, Rosmary Nichele Malfatti, Célia de Fraga |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Boniatti, Rosiana Baldin, Estela Knopp Kerstner Steffens, Daniela Pavulack, Daniela Pranke, Patricia Helena Lucas Brandalise, Rosmary Nichele Malfatti, Célia de Fraga |
dc.subject.por.fl_str_mv |
Titânio Revestimentos compósitos Compósitos híbridos Biomateriais |
topic |
Titânio Revestimentos compósitos Compósitos híbridos Biomateriais |
description |
Calcium phosphate coatings have been applied to titanium metal substrates and their alloys as a synergistic alternative capable of combining the mechanical properties of metals and the excellent bioactive properties provided by ceramic materials. However, the unsatisfactory adhesion of hydroxyapatite coatings on metallic substrates, as well as their limitation when subjected to mechanical stresses have been reported as a limitation. Biofunctional coatings have been proposed as an alternative to single ceramic coatings, aiming at optimizing the long-term clinical success of biomaterials such as Ti. This work aims at evaluating the morphological properties and biological behavior of Ti-cp coated with matrix composite coating hydroxyapatite-containing hybrid. The hybrid matrix was obtained from TEOS and MTES silicon precursors, with dispersed hydroxyapatite suspended by dip coating. For the morphological characterization FTIR, SEM/FEG, AFM and contact angle measurement were used. Biological behavior was evaluated for toxicity, cell viability and the osteogenic differentiation capacity of mesenchymal stem cells. The composite coatings obtained showed regular dispersion of hydroxyapatite particles in the hybrid matrix, with uniform coating adhering to the Ti-Cp substrate. Nevertheless, although they provided similar viability behavior of mesenchymal stem cells to the Ti-Cp substrate, the evaluated coatings did not present osteoinductive properties. This result is probably due to the pronounced hydrophobic behavior caused by the incorporation of HA. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-07-07T04:35:47Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/223362 |
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0957-4530 |
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001127892 |
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0957-4530 001127892 |
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http://hdl.handle.net/10183/223362 |
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eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of materials science : materials in medicine. London. Vol. 31 (2020), article 82, p. 1-10 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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