Progranulin serum levels in human kidney transplant recipients : a longitudinal study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/196682 |
Resumo: | Background: The adipokine progranulin has metabolic proprieties, playing a role in obesity and insulin resistance. Its levels seems to be dependent of renal function, since higher progranulin concentration is observed in patients with end-stage kidney disease. However, the effect of kidney transplantation on progranulin remains unknown. Objective To assess the serum progranulin levels in kidney transplant recipients before and after kidney transplantation. Methods: Forty-six prospective kidney transplant recipients were included in this longitudinal study. They were evaluated before transplantation and at three and twelve months after transplantation. Clinical, anthropometric and laboratorial measurements were assessed. Progranulin was determined with enzyme-linked immunosorbent assays. Results: Serum progranulin significantly decreased in the early period after transplantation (from 72.78 ± 2.86 ng/mL before transplantation to 40.65 ± 1.49 ng/mL at three months; p<0.01) and increased at one year (53.15 ± 2.55 ng/mL; p<0.01 vs. three months), remaining significantly lower than before transplantation (p<0.01) (pover time<0.01). At one year after transplantation, there was a significant increase in body mass index, trunk fat and waist circumference compared to immediate period after transplantation. Progranulin was associated with waist circumference and fasting plasma glucose after adjusted for age, gender, study period, glomerular filtration rate, interleukin-6, high sensitivity C reactive protein and adiponectin. Conclusion: Progranulin serum levels are increased before transplantation and a reduction is observed in the early period after transplantation, possibly attributed to an improvement in renal function. At one year after transplantation, an increment in progranulin is observed, seems to be independent of glomerular filtration, and remained significantly lower than before transplantation. |
id |
UFRGS-2_ae91b026543e41c0b859495dbcd556d2 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/196682 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Nicoletto, Bruna BellincantaPedrollo, Elis ForcelliniCarpes, Larissa SalomoniColoretti, Natália GomesKrolikowski, Thaiana CirinoSouza, Gabriela CorrêaGonçalves, Luiz Felipe SantosManfro, Roberto CerattiCanani, Luis Henrique Santos2019-07-09T02:38:35Z20181932-6203http://hdl.handle.net/10183/196682001095946Background: The adipokine progranulin has metabolic proprieties, playing a role in obesity and insulin resistance. Its levels seems to be dependent of renal function, since higher progranulin concentration is observed in patients with end-stage kidney disease. However, the effect of kidney transplantation on progranulin remains unknown. Objective To assess the serum progranulin levels in kidney transplant recipients before and after kidney transplantation. Methods: Forty-six prospective kidney transplant recipients were included in this longitudinal study. They were evaluated before transplantation and at three and twelve months after transplantation. Clinical, anthropometric and laboratorial measurements were assessed. Progranulin was determined with enzyme-linked immunosorbent assays. Results: Serum progranulin significantly decreased in the early period after transplantation (from 72.78 ± 2.86 ng/mL before transplantation to 40.65 ± 1.49 ng/mL at three months; p<0.01) and increased at one year (53.15 ± 2.55 ng/mL; p<0.01 vs. three months), remaining significantly lower than before transplantation (p<0.01) (pover time<0.01). At one year after transplantation, there was a significant increase in body mass index, trunk fat and waist circumference compared to immediate period after transplantation. Progranulin was associated with waist circumference and fasting plasma glucose after adjusted for age, gender, study period, glomerular filtration rate, interleukin-6, high sensitivity C reactive protein and adiponectin. Conclusion: Progranulin serum levels are increased before transplantation and a reduction is observed in the early period after transplantation, possibly attributed to an improvement in renal function. At one year after transplantation, an increment in progranulin is observed, seems to be independent of glomerular filtration, and remained significantly lower than before transplantation.application/pdfengPloS one. San Francisco. Vol. 13, no. 3 (Mar. 2018), e0192959, 12 p.Transplante de rimAdipocinasGlicoproteinasAntropometriaComposição corporalTestes laboratoriaisEstudos longitudinaisProgranulin serum levels in human kidney transplant recipients : a longitudinal studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001095946.pdf.txt001095946.pdf.txtExtracted Texttext/plain43791http://www.lume.ufrgs.br/bitstream/10183/196682/2/001095946.pdf.txta852c02501dcb7b5ff65ba43f7025991MD52ORIGINAL001095946.pdfTexto completo (inglês)application/pdf1058259http://www.lume.ufrgs.br/bitstream/10183/196682/1/001095946.pdfa5d9eb232f0666346337d0f9c3e0a67fMD5110183/1966822023-09-24 03:38:56.844111oai:www.lume.ufrgs.br:10183/196682Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-24T06:38:56Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Progranulin serum levels in human kidney transplant recipients : a longitudinal study |
title |
Progranulin serum levels in human kidney transplant recipients : a longitudinal study |
spellingShingle |
Progranulin serum levels in human kidney transplant recipients : a longitudinal study Nicoletto, Bruna Bellincanta Transplante de rim Adipocinas Glicoproteinas Antropometria Composição corporal Testes laboratoriais Estudos longitudinais |
title_short |
Progranulin serum levels in human kidney transplant recipients : a longitudinal study |
title_full |
Progranulin serum levels in human kidney transplant recipients : a longitudinal study |
title_fullStr |
Progranulin serum levels in human kidney transplant recipients : a longitudinal study |
title_full_unstemmed |
Progranulin serum levels in human kidney transplant recipients : a longitudinal study |
title_sort |
Progranulin serum levels in human kidney transplant recipients : a longitudinal study |
author |
Nicoletto, Bruna Bellincanta |
author_facet |
Nicoletto, Bruna Bellincanta Pedrollo, Elis Forcellini Carpes, Larissa Salomoni Coloretti, Natália Gomes Krolikowski, Thaiana Cirino Souza, Gabriela Corrêa Gonçalves, Luiz Felipe Santos Manfro, Roberto Ceratti Canani, Luis Henrique Santos |
author_role |
author |
author2 |
Pedrollo, Elis Forcellini Carpes, Larissa Salomoni Coloretti, Natália Gomes Krolikowski, Thaiana Cirino Souza, Gabriela Corrêa Gonçalves, Luiz Felipe Santos Manfro, Roberto Ceratti Canani, Luis Henrique Santos |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nicoletto, Bruna Bellincanta Pedrollo, Elis Forcellini Carpes, Larissa Salomoni Coloretti, Natália Gomes Krolikowski, Thaiana Cirino Souza, Gabriela Corrêa Gonçalves, Luiz Felipe Santos Manfro, Roberto Ceratti Canani, Luis Henrique Santos |
dc.subject.por.fl_str_mv |
Transplante de rim Adipocinas Glicoproteinas Antropometria Composição corporal Testes laboratoriais Estudos longitudinais |
topic |
Transplante de rim Adipocinas Glicoproteinas Antropometria Composição corporal Testes laboratoriais Estudos longitudinais |
description |
Background: The adipokine progranulin has metabolic proprieties, playing a role in obesity and insulin resistance. Its levels seems to be dependent of renal function, since higher progranulin concentration is observed in patients with end-stage kidney disease. However, the effect of kidney transplantation on progranulin remains unknown. Objective To assess the serum progranulin levels in kidney transplant recipients before and after kidney transplantation. Methods: Forty-six prospective kidney transplant recipients were included in this longitudinal study. They were evaluated before transplantation and at three and twelve months after transplantation. Clinical, anthropometric and laboratorial measurements were assessed. Progranulin was determined with enzyme-linked immunosorbent assays. Results: Serum progranulin significantly decreased in the early period after transplantation (from 72.78 ± 2.86 ng/mL before transplantation to 40.65 ± 1.49 ng/mL at three months; p<0.01) and increased at one year (53.15 ± 2.55 ng/mL; p<0.01 vs. three months), remaining significantly lower than before transplantation (p<0.01) (pover time<0.01). At one year after transplantation, there was a significant increase in body mass index, trunk fat and waist circumference compared to immediate period after transplantation. Progranulin was associated with waist circumference and fasting plasma glucose after adjusted for age, gender, study period, glomerular filtration rate, interleukin-6, high sensitivity C reactive protein and adiponectin. Conclusion: Progranulin serum levels are increased before transplantation and a reduction is observed in the early period after transplantation, possibly attributed to an improvement in renal function. At one year after transplantation, an increment in progranulin is observed, seems to be independent of glomerular filtration, and remained significantly lower than before transplantation. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-07-09T02:38:35Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/196682 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001095946 |
identifier_str_mv |
1932-6203 001095946 |
url |
http://hdl.handle.net/10183/196682 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PloS one. San Francisco. Vol. 13, no. 3 (Mar. 2018), e0192959, 12 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/196682/2/001095946.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/196682/1/001095946.pdf |
bitstream.checksum.fl_str_mv |
a852c02501dcb7b5ff65ba43f7025991 a5d9eb232f0666346337d0f9c3e0a67f |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224970739646464 |