Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/118734 |
Resumo: | Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate of American, European and African admixture of the Chilean population. Subjects and Methods: Forty single nucleotide polymorphisms (SNP´s) which exhibit substantially different frequencies between Amerindian populations (ancestryinformative markers or AIM´s), were genotyped in a sample of 923 Chilean participants to estimate individual genetic ancestry. Results: The American, European and African individual average admixture estimates for the 15 Chilean Regions were relatively homogeneous and not statistically different. However, higher American components were found in northern and southern Chile and higher European components were found in central Chile. A negative correlation between African admixture and latitude was observed. On the average, American and European genetic contributions were similar and significantly higher than the African contribution. Weighted mean American, European and African genetic contributions of 44.34% ± 3 9%, 51.85% ± 5.44% and 3.81% ± 0 .45%, were estimated. Fifty two percent of subjects harbor African genes. Individuals with Aymara and Mapuche surnames have an American admixture of 58.64% and 68.33%, respectively. Conclusions: Half of the Chilean population harbors African genes. Participants with Aymara and Mapuche surnames had a higher American genetic contribution than the general Chilean population. These results confirm the usefulness of surnames as a first approximation to determine genetic ancestry |
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Fuentes, MacarenaPulgar, IvánGallo, CarlaBortolini, Maria CátiraCanizales-Quinteros, SamuelBedoya, GabrielGonzález-José, RolandoRuiz-Linares, AndresRothhammer, Francisco2015-07-08T02:06:54Z20140034-9887http://hdl.handle.net/10183/118734000951635Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate of American, European and African admixture of the Chilean population. Subjects and Methods: Forty single nucleotide polymorphisms (SNP´s) which exhibit substantially different frequencies between Amerindian populations (ancestryinformative markers or AIM´s), were genotyped in a sample of 923 Chilean participants to estimate individual genetic ancestry. Results: The American, European and African individual average admixture estimates for the 15 Chilean Regions were relatively homogeneous and not statistically different. However, higher American components were found in northern and southern Chile and higher European components were found in central Chile. A negative correlation between African admixture and latitude was observed. On the average, American and European genetic contributions were similar and significantly higher than the African contribution. Weighted mean American, European and African genetic contributions of 44.34% ± 3 9%, 51.85% ± 5.44% and 3.81% ± 0 .45%, were estimated. Fifty two percent of subjects harbor African genes. Individuals with Aymara and Mapuche surnames have an American admixture of 58.64% and 68.33%, respectively. Conclusions: Half of the Chilean population harbors African genes. Participants with Aymara and Mapuche surnames had a higher American genetic contribution than the general Chilean population. These results confirm the usefulness of surnames as a first approximation to determine genetic ancestryapplication/pdfspaRevista Medica de Chile. Santiago. Vol. 142, (2014), p. 281-289Genoma humanoAmeríndiosIndios sul-americanosChileAmerican native continental ancestry groupChileIndiansSouth americanGeografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanosGene geography of Chile. Regional distribution of American, European and African genetic contributions Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000951635.pdf000951635.pdfTexto completo (espanhol)application/pdf353770http://www.lume.ufrgs.br/bitstream/10183/118734/1/000951635.pdf268570463545819b4b9c01e6cd715953MD51TEXT000951635.pdf.txt000951635.pdf.txtExtracted Texttext/plain33768http://www.lume.ufrgs.br/bitstream/10183/118734/2/000951635.pdf.txt0a3535a1ad373343cbcab28b5f8d06e6MD52THUMBNAIL000951635.pdf.jpg000951635.pdf.jpgGenerated Thumbnailimage/jpeg1986http://www.lume.ufrgs.br/bitstream/10183/118734/3/000951635.pdf.jpg1aa16443609599cf9ccb197c8bcd5a54MD5310183/1187342018-10-22 08:32:35.052oai:www.lume.ufrgs.br:10183/118734Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-22T11:32:35Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos |
dc.title.alternative.en.fl_str_mv |
Gene geography of Chile. Regional distribution of American, European and African genetic contributions |
title |
Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos |
spellingShingle |
Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos Fuentes, Macarena Genoma humano Ameríndios Indios sul-americanos Chile American native continental ancestry group Chile Indians South american |
title_short |
Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos |
title_full |
Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos |
title_fullStr |
Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos |
title_full_unstemmed |
Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos |
title_sort |
Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos |
author |
Fuentes, Macarena |
author_facet |
Fuentes, Macarena Pulgar, Iván Gallo, Carla Bortolini, Maria Cátira Canizales-Quinteros, Samuel Bedoya, Gabriel González-José, Rolando Ruiz-Linares, Andres Rothhammer, Francisco |
author_role |
author |
author2 |
Pulgar, Iván Gallo, Carla Bortolini, Maria Cátira Canizales-Quinteros, Samuel Bedoya, Gabriel González-José, Rolando Ruiz-Linares, Andres Rothhammer, Francisco |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fuentes, Macarena Pulgar, Iván Gallo, Carla Bortolini, Maria Cátira Canizales-Quinteros, Samuel Bedoya, Gabriel González-José, Rolando Ruiz-Linares, Andres Rothhammer, Francisco |
dc.subject.por.fl_str_mv |
Genoma humano Ameríndios Indios sul-americanos Chile |
topic |
Genoma humano Ameríndios Indios sul-americanos Chile American native continental ancestry group Chile Indians South american |
dc.subject.eng.fl_str_mv |
American native continental ancestry group Chile Indians South american |
description |
Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate of American, European and African admixture of the Chilean population. Subjects and Methods: Forty single nucleotide polymorphisms (SNP´s) which exhibit substantially different frequencies between Amerindian populations (ancestryinformative markers or AIM´s), were genotyped in a sample of 923 Chilean participants to estimate individual genetic ancestry. Results: The American, European and African individual average admixture estimates for the 15 Chilean Regions were relatively homogeneous and not statistically different. However, higher American components were found in northern and southern Chile and higher European components were found in central Chile. A negative correlation between African admixture and latitude was observed. On the average, American and European genetic contributions were similar and significantly higher than the African contribution. Weighted mean American, European and African genetic contributions of 44.34% ± 3 9%, 51.85% ± 5.44% and 3.81% ± 0 .45%, were estimated. Fifty two percent of subjects harbor African genes. Individuals with Aymara and Mapuche surnames have an American admixture of 58.64% and 68.33%, respectively. Conclusions: Half of the Chilean population harbors African genes. Participants with Aymara and Mapuche surnames had a higher American genetic contribution than the general Chilean population. These results confirm the usefulness of surnames as a first approximation to determine genetic ancestry |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-07-08T02:06:54Z |
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Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/118734 |
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0034-9887 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000951635 |
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0034-9887 000951635 |
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http://hdl.handle.net/10183/118734 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.ispartof.pt_BR.fl_str_mv |
Revista Medica de Chile. Santiago. Vol. 142, (2014), p. 281-289 |
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openAccess |
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